Navigation Links
UAB researchers find 4 biomarkers important in colorectal cancer treatment prognosis
Date:4/19/2010

BIRMINGHAM, Ala. Researchers at the University of Alabama at Birmingham (UAB) Department of Pathology have discovered a set of four biomarkers that will help predict which patients are more likely to develop aggressive colorectal cancer and which are not. The findings also shed light on the genetics that result in worse colorectal cancer-treatment outcomes for African-Americans, compared with Caucasians, the researchers said.

In data presented April 19 at the American Association of Cancer Research annual meeting in Washington, D.C., Liselle Bovell, a graduate student working in the laboratory of UAB Associate Professor of Pathology Upender Manne, Ph.D., discovered that patients who tested positive for higher levels of a genetic biomarker called microRNA (miRNA) had increased risk of death after being treated for colorectal cancer.

In genetic tests of tumor samples from the patients, the presence of higher levels of miRNA-21 and miR-106a signaled poorer prognosis after treatment for both Caucasian and African-American patients compared with patients who did not have the higher miRNA levels. The presence of higher levels of miR-181b and miR-203 signaled poorer prognosis after treatment for African-American patients, but not for Caucasians.

"This knowledge gives us solid, prognostic information, so we can better manage patients with these cancers early after diagnosis or surgery," Bovell said.

Nobel Laureate Philip A. Sharp, Ph.D., of the Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology, hosted a press conference at the annual meeting that included Bovell and other researchers. In a statement, Sharp said, "The science of miRNAs and related small RNAs will continue to generate new insights into cancer and possible future treatment."

The UAB researchers analyzed data from 218 patients who underwent surgery and other treatments for colorectal cancer at UAB Hospital between 1982 and 2004. They examined the gene-test results of tumor and benign-tissue samples and discovered the four miRNAs important to assessing patient survival.

For many cancers, including colon cancer, African-Americans have lower survival rates than whites. Possible reasons behind this disparity including genetic variation, tumor characteristics, access to health care and other factors are being examined extensively.

"Our findings underscore the potential clinical usefulness of miRNAs in studying cancer risk and cancer progression, and we've shown that race and ethnicity should be considered in the evaluation," Manne said.


'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Related medicine news :

1. UCSF Researchers Identify Regulator of Human Sperm Cells
2. Researchers find broad spectrum antiviral that fights multitude of viruses
3. University of Alberta researchers develop drug interface to save lives
4. Caregivers of ICU patients are collateral damage of critical illness, say Pitt researchers
5. Researchers fight world hunger by mapping the soybean genome
6. HIV researchers solve key puzzle after 20 years of trying
7. UC Davis researchers identify brain protein for synapse development
8. UCLA cancer researchers perform complete genomic sequencing of brain cancer cell line
9. Researchers find new way to study how enzymes repair DNA damage
10. UCLA researchers image earliest signs of Alzheimers, before symptoms appear
11. Researchers find leukemia cells metabolize fat to avoid cell death
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... , ... June 24, 2016 , ... People across the ... Genome magazine’s Code Talker Award, an essay contest in which patients and their families ... to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... is proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon ... beautiful women in the world, and the most handsome men, look naturally attractive. ...
(Date:6/24/2016)... Frederick, Maryland (PRWEB) , ... June 24, 2016 ... ... Mid-Atlantic Angels is actively feeding the Frederick area economy by obtaining investment capital ... support over the past 2½ years that have already resulted in more than ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) ... held on June 20th at the Woodmont Country Club at 1201 Rockville Pike, ... organization dedicated to helping service members that have been wounded in battle and their ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... supporting the upcoming 2016 Miss Arizona pageant as its official Medspa Sponsor. Dr. ... Tempe, Mesa, and Chandler, Arizona. , Dr. Olson says the decision to ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  American Respiratory Labs (ARL), a ... now able to perform sophisticated lung assessments in patients, homes, thanks ... Inc. Patients are no longer limited to having ... PRO ® , ARL patients like Jeanne R. of ... the comfort of her own home. ...
(Date:6/24/2016)... June 24, 2016 According to ... Type (Standard Pen Needles, Safety Pen Needles), Needle Length ... Growth Hormone), Mode of Purchase (Retail, Non-Retail) - Trends ... report studies the market for the forecast period of ... USD 2.81 Billion by 2021 from USD 1.65 Billion ...
(Date:6/24/2016)... , Belgium , June 24, ... VNRX), today announced the appointment of Dr. ... Directors as a Non-Executive Director, effective June 23, ... Audit, Compensation and Nominations and Governance Committees.  As ... Futcher will provide independent expertise and strategic counsel ...
Breaking Medicine Technology: