Navigation Links
UAB researchers find 4 biomarkers important in colerectal cancer treatment prognosis

BIRMINGHAM, Ala. Researchers at the University of Alabama at Birmingham (UAB) Department of Pathology have discovered a set of four biomarkers that will help predict which patients are more likely to develop aggressive colorectal cancer and which are not. The findings also shed light on the genetics that result in worse colorectal cancer-treatment outcomes for African-Americans, compared with Caucasians, the researchers said.

In data presented April 19 at the American Association of Cancer Research annual meeting in Washington, D.C., Liselle Bovell, a graduate student working in the laboratory of UAB Associate Professor of Pathology Upender Manne, Ph.D., discovered that patients who tested positive for higher levels of a genetic biomarker called microRNA (miRNA) had increased risk of death after being treated for colorectal cancer.

In genetic tests of tumor samples from the patients, the presence of higher levels of miRNA-21 and miR-106a signaled poorer prognosis after treatment for both Caucasian and African-American patients compared with patients who did not have the higher miRNA levels. The presence of higher levels of miR-181b and miR-203 signaled poorer prognosis after treatment for African-American patients, but not for Caucasians.

"This knowledge gives us solid, prognostic information, so we can better manage patients with these cancers early after diagnosis or surgery," Bovell said.

Nobel Laureate Philip A. Sharp, Ph.D., of the Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology, hosted a press conference at the annual meeting that included Bovell and other researchers. In a statement, Sharp said, "The science of miRNAs and related small RNAs will continue to generate new insights into cancer and possible future treatment."

The UAB researchers analyzed data from 218 patients who underwent surgery and other treatments for colorectal cancer at UAB Hospital between 1982 and 2004. They examined the gene-test results of tumor and benign-tissue samples and discovered the four miRNAs important to assessing patient survival.

For many cancers, including colon cancer, African-Americans have lower survival rates than whites. Possible reasons behind this disparity including genetic variation, tumor characteristics, access to health care and other factors are being examined extensively.

"Our findings underscore the potential clinical usefulness of miRNAs in studying cancer risk and cancer progression, and we've shown that race and ethnicity should be considered in the evaluation," Manne said.


Contact: Troy Goodman
University of Alabama at Birmingham

Related medicine news :

1. USC researchers discover new molecular subtype of brain cancer
2. Plant pathogen genetically tailors attacks to each part of host, say Stanford researchers
3. Researchers find compound effective in destroying antibiotic-resistant biofilms
4. Boston researchers lead $15 million federal research grant to support advancement of health IT
5. Researchers discover new approach for identifying smokers at highest risk for developing lung cancer
6. Researchers aim for consensus on measuring the impact of visual impairment
7. Researchers Boost Post-Heart Attack Survival in Mice
8. Researchers quantify benefits of minimally invasive removal of hard-to-reach tumors
9. Researchers design self-test for memory disorders
10. Researchers identify potential new target for treating hepatitis C
11. Researchers Identify 2 Genes Linked to Fatty Liver Disease
Post Your Comments:
(Date:11/30/2015)... Fla. (PRWEB) , ... November 30, 2015 , ... ... opened the driverless vehicle experience this summer, ushering in a new era of ... percent driverless and electric shuttle, will continue to offer guests an up-close look ...
(Date:11/30/2015)... ... 30, 2015 , ... The presidential race normally deals with political issues of ... a national news story when Donald Trump makes disparaging remarks about Hillary Clinton’s hairstyle? ... than anyone wants to admit when it comes to how people are viewed by ...
(Date:11/30/2015)... , ... November 30, 2015 , ... ... continuing education course in Dallas, TX, on January 29 and 30, 2016. The ... improve the functions of their practices, to learn how to better succeed in ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... component of bacteria could be effective in fighting methicillin-resistant Staphylococcus aureus (MRSA), one ... , Their study showed that small molecule analogs that target the functions of ...
(Date:11/30/2015)... ... 30, 2015 , ... Dr. Seth D. Margulies specializes in orthodontics and is ... Margulies to experience the best available orthodontic experience in the area. Dr. Margulies ... , Orthodontics is the branch of dentistry that specializes in the diagnosis, prevention, and ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... Asia,s largest exhibition and conference dedicated to the Medical ...  - 22 nd April 2016. --> --> ... --> -->   --> ... aging population and the government back up, the Medical Device is one of ... States . With the aging population and the government back up, the ...
(Date:11/30/2015)... 30, 2015 Nevro Corp. (NYSE: NVRO ), ... solutions for the treatment of chronic pain, today announced that ... Patent and Trademark Office (USPTO) has denied instituting an ... (the ,102 patent).  --> ... Scientific Corporation filed two petitions challenging the validity of certain ...
(Date:11/30/2015)... , Nov. 30, 2015 ... of the "Orphan Drugs Market 2015-2019" ... ) has announced the addition of the ... offering. --> Research and Markets ( ... "Orphan Drugs Market 2015-2019" report to ...
Breaking Medicine Technology: