Navigation Links
UAB researchers draft 3-D protein map to aid stroke, cancer research
Date:6/25/2009

BIRMINGHAM, Ala. A new three-dimensional computer protein map is helping researchers at the University of Alabama at Birmingham (UAB) unravel the biological pathways that control brain-cell death after a stroke.

The new map will help identify new drug targets and test compounds to slow brain-cell death, halt brain cancer and improve pain control, the study authors said. The findings are published online in the Journal of Biological Chemistry.

Starting with known cell coordinates, biological structures and other data, UAB researchers focused on a protein called acid-sensing ion channel-1, or ASIC-1. This protein acts as a gateway on the surface of brain cells called neurons. The researchers generated a 3-D computer map of ASIC-1, which greatly simplifies the testing of any drug or compound designed to protect neurons, regulate their molecular interactions or isolate brain tumors.

"This protein ASIC-1 has a lot of little nooks and crevices where other molecules can sit and interact with the channel," said Yawar Qadri, a graduate student in the UAB Department of Physiology and Biophysics and the study's lead author. "With the map we've generated and the area we've described, researchers can fine-tune their ideas and tailor experimental compounds."

Dale Benos, Ph.D., chair of the Department of Physiology and Biophysics and a co-author on the study, said the ASIC-1 map is an invaluable tool in the ongoing search for new drugs that will specifically act on this biological pathway.

"The hope is that when a person has a stroke or they get diagnosed with a brain tumor, the patient can be given a drug that will keep his or her neurons alive and functioning longer, or we can keep cancer from migrating further," Benos said.

The study began with a toxin found only in the venom of the Trinidad chevron tarantula. In earlier laboratory research, this venom toxin proved capable of slowing neuronal death, inhibiting
'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... According to Transparency Market Research “Endoscopy ... Analysis and Forecast, 2011 – 2017,” the global endoscopy ... year 2011 and is expected to reach USD 10.8 ... from 2011 to 2017. Flexible endoscopes formed the largest ... 2,201 million for the year 2011. , Related Report ...
(Date:6/19/2013)... Ore. For years, Alzheimer,s researchers have focused on ... with Alzheimer,s and may contribute to the disease: plaques ... another protein, called tau. , But for the first ... the two proteins independently, but at the interaction of ... brain tissue of post-mortem Alzheimer,s patients and in mouse ...
(Date:6/19/2013)... 19, 2013 AquaPrint Solutions in Thomson, IL ... Grub with a newly-designed Harley Davidson motorcycle gas tank. A ... Solutions with an idea of taking a split tank motorcycle ... and transforming it into a work of art. , ... Grub several toilet seats that had been dipped in a ...
(Date:6/19/2013)... 19, 2013 The Cancer Support Community ... of cancer care for the whole patient with the ... Cancer Support Community. This inaugural event, held at the ... MD., Ph.D., recognition of Congress members who have made ... of patients and families currently engaged in the cancer ...
(Date:6/19/2013)... (PRWEB) June 19, 2013 North ... PT continuing education course with an online ... therapy assistants and occupational therapists. , ... course supplemented by an online continuing education ... level algorithmic problem solving skills needed to evaluate ...
Breaking Medicine News(10 mins):Health News:Endoscopy Devices Market Will Reach USD 10.8 Billion in 2017 : Transparency Market Research 2Health News:Endoscopy Devices Market Will Reach USD 10.8 Billion in 2017 : Transparency Market Research 3Health News:New Alzheimer's research suggests possible cause: The interaction of proteins in the brain 2Health News:AquaPrint Solutions Transforms Harley Davidson Gas Tank into a Work Of Art for Poopy’s Pub & Grub 2Health News:Keeping the Promise of Cancer Care for the Whole Patient 2Health News:Keeping the Promise of Cancer Care for the Whole Patient 3Health News:New Evidence Based Information on Treatment for Over 8 Million People in the U.S. Affected With Disorders of the Vestibular System 2
... one million families offering strategies for living a healthier ... Dr. Jamie McManus, Shaklee Corporation,s Chief Medical Officer, ... promote an opportunity that seeks to offer better health ... The Infinite Possibilities tour comes to the Radisson Hotel ...
... to a Healthier, More Productive PracticeNEWBERG, Ore., Feb. ... technology and is well-positioned to fit small spaces ... offers customers a mid-level platform choice that,s lower ... the high performance, service, and support that distinguish ...
... people ignore the ,whisper, of trouble , , FRIDAY, Feb. 27 ... stroke, you,d seek immediate medical attention. But what if your ... experience vague symptoms of a stroke suffer mental and physical ... , The implicit message? Don,t wait for the worst ...
... MEMPHIS, Tenn., Feb. 27 Smith & Nephew, Inc.,(NYSE: ... Trauma today announced the,introduction of a metal liner option ... system used in hip replacement and resurfacing,procedures. , ... by the Food and Drug Administration,for use with the ...
... February 26, 2009 Contrary to conventional medical wisdom, ... shows that healthy elderly patients with severe to profound ... cochlear implants with minimal risk. "Due to concerns ... with hearing loss are not receiving the implants which ...
... the National Hospice and Palliative Care Organization released ... Medicare Payment Advisory Commission,s (MedPAC) March report to ... Medicare hospice benefit.Each year, more than 1.4 million ... Medicare hospice benefit is responsible for millions of ...
Cached Medicine News:Health News:Shaklee Helps Create Healthier Lives With Its Infinite Possibilities Tour 2Health News:New A-dec 300(TM) Offers Dentists an Innovative Equipment Solution 2Health News:Even Mild Strokes Can Do Harm 2Health News:Even Mild Strokes Can Do Harm 3Health News:Smith & Nephew Introduces Metal Liner Option for the Modular R3(TM) Acetabular Cup System 2Health News:Smith & Nephew Introduces Metal Liner Option for the Modular R3(TM) Acetabular Cup System 3Health News:NYU Langone Medical Center study shows that cochlear implant surgery is safe for the elderly 2Health News:NHPCO Statement on MedPAC Recommendations to Congress 2Health News:NHPCO Statement on MedPAC Recommendations to Congress 3
(Date:6/19/2013)... , June 19, 2013   Nektar Therapeutics (Nasdaq: ... a human abuse liability (HAL) study for NKTR-181, ... entry into the brain.  This slow rate of entry is ... abuse of and addiction to current opioid analgesics. 1 ... was rated similar to placebo in "drug liking" and "feeling ...
(Date:6/19/2013)... Calif. , June 19, 2013 BD Biosciences, ... BDX ), a leading global medical technology company, today ... Analyzer , the latest in its line of high-performance research ... Analyzer delivers high-performance multicolor analysis with the most compact footprint ... 73.7 cm) and a height of 30" (76.2 cm). Recognizing ...
(Date:6/19/2013)... , June 19, 2013 NeuroDerm, ... study in volunteers, and preliminary results from a phase ... presented at the 2013 International Congress of Parkinson,s Disease ... drug formula under development for continuous administration through a ... plasma concentrations. ND0612 has been shown in ...
Breaking Medicine Technology:Nektar Therapeutics Presents Positive Data from Human Abuse Liability Study for NKTR-181, a First-in-Class Investigational Opioid to Treat Chronic Pain, at 2013 Annual Meeting of The College on Problems of Drug Dependence 2Nektar Therapeutics Presents Positive Data from Human Abuse Liability Study for NKTR-181, a First-in-Class Investigational Opioid to Treat Chronic Pain, at 2013 Annual Meeting of The College on Problems of Drug Dependence 3Nektar Therapeutics Presents Positive Data from Human Abuse Liability Study for NKTR-181, a First-in-Class Investigational Opioid to Treat Chronic Pain, at 2013 Annual Meeting of The College on Problems of Drug Dependence 4Nektar Therapeutics Presents Positive Data from Human Abuse Liability Study for NKTR-181, a First-in-Class Investigational Opioid to Treat Chronic Pain, at 2013 Annual Meeting of The College on Problems of Drug Dependence 5Nektar Therapeutics Presents Positive Data from Human Abuse Liability Study for NKTR-181, a First-in-Class Investigational Opioid to Treat Chronic Pain, at 2013 Annual Meeting of The College on Problems of Drug Dependence 6Nektar Therapeutics Presents Positive Data from Human Abuse Liability Study for NKTR-181, a First-in-Class Investigational Opioid to Treat Chronic Pain, at 2013 Annual Meeting of The College on Problems of Drug Dependence 7Nektar Therapeutics Presents Positive Data from Human Abuse Liability Study for NKTR-181, a First-in-Class Investigational Opioid to Treat Chronic Pain, at 2013 Annual Meeting of The College on Problems of Drug Dependence 8Nektar Therapeutics Presents Positive Data from Human Abuse Liability Study for NKTR-181, a First-in-Class Investigational Opioid to Treat Chronic Pain, at 2013 Annual Meeting of The College on Problems of Drug Dependence 9New BD Biosciences Flow Cytometry Cell Analyzer Enables Complex Multicolor Experiments in Disease Research 2NeuroDerm Announces Presentation of Data from Studies Evaluating ND0612, an Investigational Levodopa Continuous Administration Drug, in Healthy Volunteers and in Patients with Advanced Parkinson's Disease 2NeuroDerm Announces Presentation of Data from Studies Evaluating ND0612, an Investigational Levodopa Continuous Administration Drug, in Healthy Volunteers and in Patients with Advanced Parkinson's Disease 3NeuroDerm Announces Presentation of Data from Studies Evaluating ND0612, an Investigational Levodopa Continuous Administration Drug, in Healthy Volunteers and in Patients with Advanced Parkinson's Disease 4NeuroDerm Announces Presentation of Data from Studies Evaluating ND0612, an Investigational Levodopa Continuous Administration Drug, in Healthy Volunteers and in Patients with Advanced Parkinson's Disease 5NeuroDerm Announces Presentation of Data from Studies Evaluating ND0612, an Investigational Levodopa Continuous Administration Drug, in Healthy Volunteers and in Patients with Advanced Parkinson's Disease 6
... 27, 2011 BioDrain Medical, Inc. (OTCBB: BIOR, OTCQB: ... automated surgical fluid disposal, today announced that it has ... underway at surgical facilities in Minnesota.  The Streamway System ... at both sites. Healthcare personnel trained in ...
... BEACH, Fla., June 27, 2011 Implementing an EHR system ... for a doctor that wants to attain Meaningful Use(1), but ... ongoing effort to assist doctors in their migration from paper ... three key services to Medical Messenger customers: ...
Cached Medicine Technology:BioDrain Streamway® System Receives Positive Evaluations on Two Additional Units 2BioDrain Streamway® System Receives Positive Evaluations on Two Additional Units 3Medical Messenger Partners With ComputerAssistant.com to Provide Key Elements of Meaningful Use Success 2
Lumicon 48 mm red filter....
Heavy duty, all purpose illuminator available in blue and green. Unique Clip Switch automatically turns off when returned to pocket. Pre-focused lens tip Heine XHL Halogen bulb for bright, concentra...
... A child-friendly vision test ... takes just seconds. Welch ... first objective, accurate vision ... early detection of refractive ...
... is a black and white ... by people who have visual ... control selector, the Classic can ... black text on a white ...
Medicine Products: