Navigation Links
UAB researchers cure type 1 diabetes in dogs
Date:2/7/2013

Researchers from the Universitat Autnoma de Barcelona (UAB), led by Ftima Bosch, have shown for the first time that it is possible to cure diabetes in large animals with a single session of gene therapy. As published this week in Diabetes, the principal journal for research on the disease, after a single gene therapy session, the dogs recover their health and no longer show symptoms of the disease. In some cases, monitoring continued for over four years, with no recurrence of symptoms.

The therapy is minimally invasive. It consists of a single session of various injections in the animal's rear legs using simple needles that are commonly used in cosmetic treatments. These injections introduce gene therapy vectors, with a dual objective: to express the insulin gene, on the one hand, and that of glucokinase, on the other. Glucokinase is an enzyme that regulates the uptake of glucose from the blood. When both genes act simultaneously they function as a "glucose sensor", which automatically regulates the uptake of glucose from the blood, thus reducing diabetic hyperglycemia (the excess of blood sugar associated with the disease).

As Ftima Bosch, the head researcher, points out, "this study is the first to demonstrate a long-term cure for diabetes in a large animal model using gene therapy."

This same research group had already tested this type of therapy on mice, but the excellent results obtained for the first time with large animals lays the foundations for the clinical translation of this gene therapy approach to veterinary medicine and eventually to diabetic patients.

The study was led by the head of the UAB's Centre for Animal Biotechnology and Gene Therapy (CBATEG) Ftima Bosch, and involved the Department of Biochemistry and Molecular Biology of the UAB, the Department of Medicine and Animal Surgery of the UAB, the Faculty of Veterinary Science of the UAB, the Department of Animal Health and Anatomy of the UAB, the Span
'/>"/>

Contact: Ftima Bosch
fatima.bosch@uab.cat
34-935-814-182
Universitat Autonoma de Barcelona
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. University of Minnesota researchers discover enzyme behind breast cancer mutations
2. Yale researchers spot attention deficits in babies who later develop autism
3. Researchers use new molecular inhibitors to successfully hit difficult cancer target
4. Researchers discover mutations linked to relapse of childhood leukemia
5. Moffitt Cancer Center researchers develop automated breast density test linked to cancer risk
6. Leading researchers warn of brain drain as scientists struggle to find funding
7. Researchers Identify Involuntary Tobacco Smoke Exposure in Boston Public Housing Authority Residents with Salivary Cotinine Testing from Salimetrics.
8. Researchers help confirm value of flow-diverting device for most challenging aneurysms
9. Researchers improve medical units to reduce nursing fatigue, cut costs
10. Researchers find gene that turns up effect of chemotherapy
11. Israeli researchers to participate in European Commission flagship
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UAB researchers cure type 1 diabetes in dogs
(Date:12/25/2014)... 24, 2014 (HealthDay News) -- Among early stage breast ... than half of one percent will eventually develop leukemia ... reveals. The finding comes from a review of ... and 2007, and it suggests that the risk for ... experts had previously thought. "The frequency of bone ...
(Date:12/25/2014)... New York (PRWEB) December 25, 2014 ... continue to move forward in a number of multidistrict ... of West Virginia, Bernstein Liebhard LLP reports. According to ... is scheduled to convene a Joint Status Conference in ... 10:00 a.m. Parties have been directed to submit a ...
(Date:12/25/2014)... North Carolina (PRWEB) December 25, 2014 ... North Carolina Retirement Community, recently showed their generous ... girls of the Catawba County Parenting Network- Grandparents ... the 10 children gathered around the largest Christmas ... to open presents purchased by residents of the ...
(Date:12/24/2014)... AlignLife of Wauwatosa loves helping those in the ... holiday season, AlignLife looks forward to their annual toy drive. ... Mahalko-Leonhardt, owner of AlignLife. "It brings our patients as well ... able to give kids toys for Christmas who would be ... of our patients." , The 70 toys were donated to ...
(Date:12/24/2014)... Connie Casad, MD, a well-known and respected ... 30 years of practice experience in Dallas, Texas, has ... of dietary detoxification. The second study is scheduled to ... from test patients who just completed a 21-day detoxification ... in conducting the study, Dr. Casad said, "About 10 ...
Breaking Medicine News(10 mins):Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 4Health News:Retirement Community Residents Make Impact During Holiday Season 2Health News:AlignLife of Wauwatosa Brings Joy to Less Fortunate Families 2Health News:Connie Casad, MD, Now Accepting Test Participants for January Dietary Detoxification Study 2Health News:Connie Casad, MD, Now Accepting Test Participants for January Dietary Detoxification Study 3
... be discouraged from drinking by doctors according to researchers. In fact ... that// moderate drinking lowered their risk of heart attack. ... half to three units of alcohol every day on average demonstrated ... healthy teetotallers. One unit is a glass of wine or a ...
... Trust in Surrey is to cut nearly 170 beds and 480 ... ,A spokeswoman for the trust said: 'The trust is reducing ... it needs fewer beds.' ,Previously 43 beds have ... axed up. ,The spokeswoman added: 'Individuals have not been identified for ...
... published in American Journal of Sports Medicine claims that a ... suffering from elbow tendonitis often termed as ‘tennis elbow’ or ... alleviate the suffering. It’s not necessarily a malady afflicting just ... This ailment starts with the degeneration of the a tendon ...
... to which, patient’s views must be taken into consideration ... ,As people are becoming more aware of their disorders ... be encouraged to know more about their care is ... insisted upon by General Medical Council. ,The ...
... researchers from the Mayo Clinic in Minnesota has found that ... of sickness, right from// common cold to polio could also ... picornavirus and its ilk can cause memory loss ... show up as an apparent shortfall in cognitive abilities. ...
... to have larger, later-stage tumors that were more difficult ... Hispanic// and Caucasian women who received the same treatment ... researchers from The University of Texas M. D. Anderson ... Oct. 23 by Cancer, a peer-reviewed journal of the ...
Cached Medicine News:Health News:Race Affects African-American Survival of Breast Cancer 2Health News:Race Affects African-American Survival of Breast Cancer 3
(Date:12/24/2014)... Dec. 23, 2014 ResMed (NYSE: RMD ... action against Chinese medical device manufacturer BMC Medical Co., Ltd. ... that BMC,s masks listed below infringe ResMed,s patents, and entered ... masks in the United States : ... mask , Willow nasal pillows mask , iVolve ...
(Date:12/24/2014)... , Dec. 23, 2014   Assurex Health, ... decision support to healthcare providers for behavioral health ... has secured $30 million in equity financing from ... C. Drosos , President and Chief Executive Officer. ... adoption and development of Assurex Health,s GeneSight ...
(Date:12/24/2014)... CHENGDU, China , Dec. 23, 2014 /PRNewswire/ ... a pharmaceutical company that specializes in patented biopharmaceutical, ... active pharmaceutical ingredients (API) today announced that the ... for its Good Manufacturing Practice (GMP) certificate of ... & Drug Administration,s (CFDA). The public notice period ...
Breaking Medicine Technology:ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3
... Expands Anti-Interleukin-9 Program with Second Phase 2a ... ... 1 MedImmune, Inc. today,announced that it has initiated a multi-dose, ... in adults with,mild, persistent asthma. The placebo-controlled, dose-escalation study is,designed to ...
... lower income and education still smoke more and are less likely ... ... survey by the,Washington State Department of Health shows the number of adult smokers ... Control Program in 2000, adult smoking has gone from 22.4,percent to a new ...
Cached Medicine Technology:MedImmune Initiates Phase 2a Multi-Dose Study in Patients with Asthma 2Adult Smoking Rate Continues Downward Trend 2
Indications For Usage: , Thoracic surgery. , Broncho-spirometry. , Thoracoscopies. , Differential or selective lung ventilation. ...
... Double lumen ... one-lung ventilation., ... Tube is packaged ... tube-to-circuit adaptors, suction ...
The TCB Univent® allows easily collapsing one lung for thoracoscopic procedures....
... Used for endobronchial blockade ... right lung for procedures ... The set consists of ... and an Arndt Multiport ...
Medicine Products: