Navigation Links
UAB joins elite brain cancer research group
Date:7/9/2008

BIRMINGHAM, Ala. Brain cancer experts at the University of Alabama at Birmingham (UAB) have been selected for membership in the Ivy Genomics-Based Medicine Project. The project is a national consortium of cutting-edge hospitals and academic centers working to improve treatment and survival for patients with a kind of malignant brain tumor called a glioma.

As part of the nine-member consortium, UAB will serve as the only research site in the Southeast. UAB is one of four consortium members working in conjunction with its own National Cancer Institute-designated comprehensive cancer center and with a Specialized Program of Research Excellence (SPORE) in brain cancer.

"Being named to this project is a huge honor for us, and it shows we've kept pace and excelled in collaborative and translational research objectives," said G. Yancey Gillespie, Ph.D., UAB professor of neurosurgery and principal investigator for the Ivy Genomics-Based Medicine Project.

Gliomas are tumors that arise by transformation of the body's glial cells, which make up 90 percent of the brain and spinal cord and normally work in concert with neurons. The consortium members strive to unravel how genetic differences between gliomas can lead to more effective and even personalized treatments for patients.

The project will categorize tumors using sophisticated molecular profiling and, for the first time, test each brain tumor against a wide spectrum of treatments to match DNA markers with differences in cancer-fighting response.

"Currently, all patients get basically the same treatment without taking into account the genetic profile of their tumor," said Catherine Ivy, founder of the Ivy Foundation and the driving force behind the genomic project.

"The end goal of this research initiative is to identify how tumors with different genetic features respond to a set of treatment regimens and ultimately, it is hoped, provide physicians with the tools they need to offer brain tumor patients the most effective treatment options," Ivy said.

UAB's membership in the Ivy Genomics-Based Medicine Project is focused on the group's first stage, which has an intensive 18-month research timeline. The nine academic laboratories will use that period to screen dozens of anti-cancer drugs in animal models that help predict tumor-fighting response.

Information from those screenings and other genetic profiling will be linked and analyzed through a secure, real-time computer network. The project's second phase will likely involve human testing of anti-cancer drugs.

Gillespie said the genomic approach has the potential to generate several "firsts" in brain cancer research. "We already are working across disciplines: neuro-oncology, neurosurgery, neuroradiology, neuropathology, pharmacology and biomedical engineering," he said. "This research promises to have a significant impact on the way we treat this disease in the future."


'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Related medicine news :

1. Global Health Progress Joins WHO and DNDi to Call For Increased Commitments to Fighting Neglected Tropical Diseases
2. Dr. Kenneth L. Byrd Joins SteriFx Inc.
3. Leading Vaccine Expert Joins IAVI
4. Marshall Norris Joins NavigatorMD as Director of Business Development and Sales
5. Dr. Howard Epstein Joins Blue Cross as Medical Director for Commercial Operations and Clinical Design
6. Uroplasty Joins the Russell Microcap Index
7. Marc Andreessen Joins Facebook Board of Directors
8. Jerry Steffl Joins Prime Therapeutics as Vice President, Government Affairs
9. Former Assistant US Surgeon General Woodie Kessel, MD, MPH, Joins Academic Network LLC as Senior Scientific Advisor
10. Karen Haney Joins The Turning Point Group as Partner and Vice President of Client Services - Healthcare
11. Bruce Palsulich Joins Relsys International as Chief Innovation & Strategy Officer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2017)... ... 27, 2017 , ... Healthy eating isn’t always easy. Currently, more than 80 percent of Americans ... Americans overeat refined grains and sugar. This trend may help explain why the obesity rate ... are obese. , As a culture, we seem to have food on the brain more. ...
(Date:7/27/2017)... ... July 27, 2017 , ... Team Novo Nordisk, the world’s first all-diabetes ... pro squad as a stagiaire for the remainder of the 2017 season. One of ... 31st at the Tour of Utah. , “Every season we are excited to move ...
(Date:7/26/2017)... ... 2017 , ... An inventor from Salisbury, N.C., knows the difficulties involved with ... and dignified way to keep leeches in place during therapy," she said. "That’s why ... an effective way to keep a leech in place on the skin during therapy. ...
(Date:7/26/2017)... , ... July 26, 2017 , ... Six greater Bay Area roller derby leagues are ... ‘em Bleed,” the most widely attended series of blood drives in California, beginning July 29. ... over the past 4 years -- enough to have helped to save up to 2700 ...
(Date:7/26/2017)... ... July 26, 2017 , ... It may be hard to imagine that the ... in the third world. Diseases that many developed countries consider rare or eradicated, like ... access to vaccines. , On an upcoming segment of "Success Files", actor Rob Lowe ...
Breaking Medicine News(10 mins):
(Date:7/24/2017)... July 24, 2017  Diplomat Pharmacy, Inc. (NYSE: ... its second quarter 2017 operating results on Monday, August ... to follow at 5:00 p.m. ET. ... to a live broadcast of the conference call by ... participant code 51641230 approximately 15 minutes prior to the ...
(Date:7/20/2017)... 2017  Prime Therapeutics LLC (Prime) released this statement from ... today,s Institute for Clinical and Economic Review,s (ICER) public ... and value of abuse-deterrent formulations (ADF) of opioids. Prime was ... the meeting. "The ... to the use of abuse-deterrent formulations (ADF) in opioids in ...
(Date:7/14/2017)... VEGAS , July 13, 2017 It should ... United States is in the midst of a ... Control , since 1999, the number of overdose deaths from ... "resulting in over half a million dead from 2001 to ... codeine, oxycodone, and hydrocodone has similarly quadrupled, drawing a compelling ...
Breaking Medicine Technology: