Navigation Links
U of U researchers to use patient's own stem cells to treat heart failure
Date:11/17/2008

SALT LAKE CITY Nov. 17, 2008 Researchers at the University of Utah are enrolling people in a new clinical trial that uses a patient's own stem cells to treat ischemic and non-ischemic heart failure.

The one-year Cardiac Repair Cell Treatment of Patients with Dilated Cardiomyopathy (IMPACT-DCM) study will look at the safety of injecting Cardiac Repair Cells (CRC) and their ability to improve heart function.

Patients enrolled in IMPACT-DCM will have their own bone marrow cells drawn (about 3 tablespoons worth), which will then be grown in a culture to expand the number of cells that will help the heart muscle and improve blood flow. Two weeks later, the patient's stem cells will be injected directly into the left ventricle of the heart during a minimally invasive surgery developed by Amit N. Patel, M.D., national principal investigator for the IMPACT-DCM trial and director of cardiovascular regenerative medicine at the University of Utah School of Medicine.

"Heart failure affects about 5 million Americans, with more than half a million new cases diagnosed each year. A subset of these patients has dilated cardiomyopathy (DCM), a condition that leaves the heart weakened, enlarged and unable to pump blood efficiently. For most of these patients, the only option has been a heart transplant," said David A. Bull, M.D., professor and division chief of Cardiothoracic Surgery in the U's medical school and site principal investigator for the trial.

"This is the first trial of its kind in the United States, providing patients who have limited to no other options with a viable treatment," said Patel, professor of surgery. "By using a patient's own cells, we eliminate the concern of rejection and the need for potentially harmful immunosuppressive drugs. We hope these cells will help with new blood vessels and support the heart muscle in order to improve the heart's function, thereby greatly improving the patient's quality of life."

Patients who have been diagnosed with congestive heart failure (NYHA Class 3 or 4) and are between the ages of 18 and 86 may be eligible to participate in the trial. The University of Utah is one of five nationwide sites conducting the IMPACT-DCM study, sponsored by Aastrom Biosciences, Inc., a company specializing in autologous cell products. IMPACT-DCM is a randomized, controlled, Phase II study that will enroll 40 patients nationwide: 20 patients with ischemic DCM and 20 patients with nonischemic DCM.


'/>"/>

Contact: Chantelle Turner
chantelle.turner@hsc.utah.edu
801-581-7387
University of Utah Health Sciences
Source:Eurekalert

Related medicine news :

1. Researchers identify toehold for HIVs assault on brain
2. Researchers Tackle CLL, Diabetes and Trauma-Hemorrhage
3. Researchers Use New Method to Control Bleeding in Hemophilia
4. Stem cells with potential to regenerate injured liver tissue identified by Penn researchers
5. Protein can nurture or devastate brain cells, depending on its friends, researchers find
6. Researchers find stem cells from monkey teeth can stimulate growth and generation of brain cells
7. Battling Bacteria in the Blood: U-M Researchers Tackle Deadly Infections
8. Researchers to Present Additional Data on Soliris(R) (eculizumab) for the Treatment of PNH at the ASH Annual Meeting
9. USC researchers identify key mechanism that regulates the development of stem cells into neurons
10. Cornell researchers study showing evidence of a major environmental trigger for autism
11. Maastricht University researchers produce neural fingerprint of speech recognition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... Falls Church, VA (PRWEB) , ... January 19, 2017 , ... ... Know to Thrive in 2017, **An FDAnews Webinar**, Jan. 26, 2016 — 1:30 p.m. ... to know about the 21st Century Cures Act in order to thrive this year? ...
(Date:1/19/2017)... Atlanta, Georgia (PRWEB) , ... January 19, 2017 ... ... Reconstructive Surgeons hosts the Atlanta Breast Surgery Symposium, a conference where hundreds of ... latest advancements in breast surgery. Covering topics from cosmetic breast augmentation ...
(Date:1/18/2017)... , ... January 18, 2017 , ... Delaware farmer Rick ... St. Louis, Missouri. , Dickerson, of Laurel, farms about a thousand acres of soybeans, ... yellow squash on contract and pumpkins and other vegetables for the fresh market. He ...
(Date:1/18/2017)... USA; and SHANGHAI, China – , ... ... -- Global public health organization NSF International has certified the ... to NSF/ANSI 53: Drinking Water Treatment Units – Health Effects, ... certification verifies that MicroCeramics’ NanoNose Pitcher Filter System filters the ...
(Date:1/18/2017)... ... January 18, 2017 , ... ... their Vice President of Franchise Development, Paula Turner Pizarro, was recently featured on ... which features the insights of top business leaders from across the globe, provides ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... 18, 2017  Kratom leaves, from a South ... often used to prepare tea-like beverages and commercially ... Americans annually to increase alertness, enhance well-being and ... minor aches and pains. PinneyAssociates, review of the ... assist FDA and DEA in determining the most ...
(Date:1/18/2017)... Colo. , Jan. 18, 2017 Safe ... chain of pharmacies based in Loveland, Colorado ... Prescription Vials (LPVs) in selected Good Day locations.     ... have a cost-effective alternative for secure storage," said ... "For less than the price of a cup of ...
(Date:1/18/2017)... 2017 Invetech, the leading developer of ... therapies , has announced a collaboration agreement with ... starvation" treatments for acute leukemia and other oncology ... Invetech will develop systems to enable the commercial-scale ... technology platform, which uses a novel technology to ...
Breaking Medicine Technology: