Navigation Links
U of T researchers identify protein
Date:9/4/2009

TORONTO -- Researchers at the University of Toronto have identified a protein which plays a key role in the development of neurons, which could enhance our understanding of how the brain works, and how diseases such as Alzheimer's occur.

U of T graduate student John Calarco, working in the labs of Prof. Ben Blencowe (Donnelly Centre for Cellular and Biomolecular Research, University of Toronto) and Prof. Mei Zhen (Samuel Lunenfeld Research Institute, Mount Sinai Hospital), has identified a protein known as nSR100, which is only found in vertebrate species and which controls a network of "alternative splicing events" that are located in the messages of genes with critical functions in the formation of the nervous system. The findings are published in a paper in the current edition of the journal Cell.

Alternative splicing events greatly expand the diversity of the genetic messages and corresponding proteins produced by genes in vertebrate cells, and this process partially accounts for the evolution of remarkable complexity in organs such as the mammalian brain. Calarco, recipient of a prestigious Alexander Graham Bell Studentship, together with colleagues in the Blencowe Lab, identified nSR100 using computational and experimental methods and then determined its role in the control of alternative splicing in the brain. These studies revealed that nSR100 regulates splicing events in genes that help form neurons.

Collaborator and co-author Brian Ciruna and his colleagues at the the Hospital for Sick Children (SickKids) in Torontofurther demonstrated that nSR100 plays a critical role in the development of the vertebrate nervous system.

"The brain is by far the most complex organ in the human body and understanding how it functions represents one of the foremost challenges of biomedical research. A large number of neurological disorders arise when the development and function of certain neurons is impaired. A major research goal is therefore to identify key genes required for the specification and function of neurons in the brain, and nSR100 represents such a gene," said Prof. Blencowe, principal investigator on the study.

Calarco added that the findings present a new avenue of investigation for researchers. "The study provides intriguing insight into how the evolution of a single protein has contributed to the expansion of brain complexity in vertebrates including humans.

Further investigation into the complex network of splicing events regulated by nSR100 may uncover important aspects of how neurons normally function and also how they become impaired in neurological diseases like Alzheimer's."


'/>"/>

Contact: April Kemick
april.kemick@utoronto.ca
416-978-5949
University of Toronto
Source:Eurekalert

Related medicine news :

1. University of Georgia researchers show component of mothballs is present in deep-space clouds
2. Researchers link inflammatory diseases to increased cardiovascular risk
3. Researchers Make Insulin-Producing Cells From Adult Skin Cells
4. Researchers identify protein involved in causing gum disease, osteoporosis, arthritis
5. Researchers find high-dose therapy for liver disease not effective
6. Researchers identify new, cancer-causing role for protein
7. Carnegie Mellon Researchers Develop Novel Tool to Rank Death Rates
8. Researchers evaluate resistance training for diabetes prevention
9. Researchers find that employees who are engaged in their work have happier home life
10. U-M researchers discover therapeutic target that could help patients with pulmonary fibrosis
11. UCSF Researchers Identify Two Key Pathways in Adaptive Response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned ... developed to enhance the health of felines. The formula is all-natural and is made ... in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American ... Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. ... including advance care planning, healthcare costs and patient and family engagement. , AIR ...
(Date:6/25/2016)... California (PRWEB) , ... June 25, 2016 , ... "With ... fit their specific project," said Christina Austin - CEO of Pixel Film Studios. ... customizable and all within Final Cut Pro X . Simply select a ProHand ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... A ... procedures that most people are unfamiliar with. The article goes on to state that ... but also many of these less common operations such as calf and cheek reduction. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- Dublin ... the " Global Markets for Spectroscopy Equipment" ... This report focuses on the global market ... its applications in various applications. The report deals with ... main industries: pharmaceutical and biotechnology, food and beverage, and ...
(Date:6/24/2016)... 24, 2016 Research and Markets has ... Companion Diagnostic Tests" report to their offering. ... Diagnostics The World Market for Companion Diagnostics ... diagnostics. Market analysis in the report includes the following: ... Vitro Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
(Date:6/23/2016)... -- MedSource announced today that it has selected Datatrial,s ... choice.  This latest decision demonstrates MedSource,s commitment to ... by offering a state-of-the-art electronic data capture (EDC) ... the EDC platform of choice in exchange for ... long been a preferred EDC platform by our ...
Breaking Medicine Technology: