Navigation Links
U of T researchers identify protein
Date:9/4/2009

TORONTO -- Researchers at the University of Toronto have identified a protein which plays a key role in the development of neurons, which could enhance our understanding of how the brain works, and how diseases such as Alzheimer's occur.

U of T graduate student John Calarco, working in the labs of Prof. Ben Blencowe (Donnelly Centre for Cellular and Biomolecular Research, University of Toronto) and Prof. Mei Zhen (Samuel Lunenfeld Research Institute, Mount Sinai Hospital), has identified a protein known as nSR100, which is only found in vertebrate species and which controls a network of "alternative splicing events" that are located in the messages of genes with critical functions in the formation of the nervous system. The findings are published in a paper in the current edition of the journal Cell.

Alternative splicing events greatly expand the diversity of the genetic messages and corresponding proteins produced by genes in vertebrate cells, and this process partially accounts for the evolution of remarkable complexity in organs such as the mammalian brain. Calarco, recipient of a prestigious Alexander Graham Bell Studentship, together with colleagues in the Blencowe Lab, identified nSR100 using computational and experimental methods and then determined its role in the control of alternative splicing in the brain. These studies revealed that nSR100 regulates splicing events in genes that help form neurons.

Collaborator and co-author Brian Ciruna and his colleagues at the the Hospital for Sick Children (SickKids) in Torontofurther demonstrated that nSR100 plays a critical role in the development of the vertebrate nervous system.

"The brain is by far the most complex organ in the human body and understanding how it functions represents one of the foremost challenges of biomedical research. A large number of neurological disorders arise when the development and function of certain neurons is impaired. A major research
'/>"/>

Contact: April Kemick
april.kemick@utoronto.ca
416-978-5949
University of Toronto
Source:Eurekalert

Page: 1 2

Related medicine news :

1. University of Georgia researchers show component of mothballs is present in deep-space clouds
2. Researchers link inflammatory diseases to increased cardiovascular risk
3. Researchers Make Insulin-Producing Cells From Adult Skin Cells
4. Researchers identify protein involved in causing gum disease, osteoporosis, arthritis
5. Researchers find high-dose therapy for liver disease not effective
6. Researchers identify new, cancer-causing role for protein
7. Carnegie Mellon Researchers Develop Novel Tool to Rank Death Rates
8. Researchers evaluate resistance training for diabetes prevention
9. Researchers find that employees who are engaged in their work have happier home life
10. U-M researchers discover therapeutic target that could help patients with pulmonary fibrosis
11. UCSF Researchers Identify Two Key Pathways in Adaptive Response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... 2014 With the stage set for ... Store Expo - which will be held in Boston ... op-ed in its online opinion section, Podium. The ... is co-authored by Steven C. Anderson, IOM, CAE, president ... of the MCPHS University School of Pharmacy – Worcester/Manchester. ...
(Date:8/22/2014)... Norton HealthDay Reporter ... number of Americans on work disability chronically use powerful ... found that between 2007 and 2011, about 44 percent ... prescribed narcotic painkillers each year. And the percentage using ... to 23 percent in 2011. Experts said ...
(Date:8/22/2014)... Millennium Treatment Group, a drug ... recently launched a new website. Patients, parents, loved ... now find Millennium Treatment Group at http://www.millenniumtreatmentgroup.com ... at the beginning of July. Everything anyone would ... found on the website. There’s an About Us ...
(Date:8/22/2014)... time an oncogenic somatic mutation at amino acid 918 ... identified in small cell lung cancer (SCLC) tumors and ... produced increased intracellular signaling and cell growth. , SCLC ... 15% of all lung cancers and is strongly associated ... has been extensively examined for genomic alterations and targeted ...
(Date:8/22/2014)... Advancements in ultrasound technologies make ... due to their cost-effectiveness, non-invasiveness, and absence of ... such as the evolution of wireless transducers and ... market moving throughout 2014 and beyond. Such Ultrasound’s ... only the point-of-care (POC) testing in hospital settings, ...
Breaking Medicine News(10 mins):Health News:The Boston Globe Publishes Value of Pharmacy Op-ed as NACDS Total Store Expo Begins 2Health News:The Boston Globe Publishes Value of Pharmacy Op-ed as NACDS Total Store Expo Begins 3Health News:Many U.S. Workers on Disability Use Narcotic Painkillers, Study Finds 2Health News:Many U.S. Workers on Disability Use Narcotic Painkillers, Study Finds 3Health News:Many U.S. Workers on Disability Use Narcotic Painkillers, Study Finds 4Health News:Millennium Treatment Group Has a New Website 2Health News:Novel oncogenic RET mutation found in small cell lung cancer 2Health News:Global Top Ultrasound Market Suppliers Assessed in New VPG Research Report Available at MarketPublishers.com 2Health News:Global Top Ultrasound Market Suppliers Assessed in New VPG Research Report Available at MarketPublishers.com 3
... Some 19 percent of soldiers returning from Iraq ... percent. While prevalence of migraine among the U.S. ... sleep quality in soldiers with chronic headaches including post-traumatic ... Madigan Army Medical Center in Tacoma, WA presenting at ...
... the American Headache Society,s 52nd Annual Scientific Meeting in Los ... leads to changes in the levels of key proteins that ... Paul L. Dunham, Ph.D. and his team at Missouri ... understand the mechanisms by which sleep disturbance increases the risk ...
... mobile phone base station during pregnancy, says study A ... Great Britain has found no association between a mother living near ... risk of that child developing cancer before reaching the age of ... is the first to look at the health effects of mobile ...
... in the department of physics at NJIT, will lead ... (NRC) of the National Academies ( www.nationalacademies.org ) to ... the aftermath of Toyota,s large recalls. The group, which ... 1, 2010 in Washington, DC, includes notable engineers, scientists ...
... 3rd party website ... rid of love handles , ... 2010 -- The newest recent launch of a fitness sites on how to get a six ... be achieved with the aid of supplements. Getting a perfectly toned muscular body with defined six ...
... high-calorie food more , TUESDAY, June 22 (HealthDay News) -- ... high-calorie snacks. Yet, your eyes keep straying toward that box ... restrain your impulse to inhale them. , Such a pill ... presented Tuesday at the Endocrine Society,s annual meeting in San ...
Cached Medicine News:Health News:No link between early childhood cancers and living near mobile phone base station during pregnancy, says study 2Health News:No link between early childhood cancers and living near mobile phone base station during pregnancy, says study 3Health News:NJIT professor heads panel studying sudden car acceleration 2Health News:How To Get A Six Pack: Site Reveals How You Can Trade In Six-Pack Of Beer For Six-Pack Abs 2Health News:Hormone Raises Desire for Fattening Foods 2Health News:Hormone Raises Desire for Fattening Foods 3
(Date:8/22/2014)... DUBLIN, Ireland , August 22, 2014 ... ,Research and Markets ( http://www.researchandmarkets.com/research/x34qgv/global_laboratory ) has announced ... Balance Market 2014-2018"  report to their offering.  ... electronic balance is an essential instrument for ... in the precise weighing of materials. It ...
(Date:8/22/2014)... , Aug. 22, 2014  As the Medical Affairs, ... many leaders in this area are exploring methods to ... The Medical Affairs Consortium at Best Practices, LLC is ... sharing insights about the key challenges they face. The ... solutions through three virtual roundtable discussions where leaders discuss ...
(Date:8/22/2014)... Aug. 22, 2014 MC Medical, a subsidiary of ... Columbus, OH medical device company, have ... laparoscopic and robotic visualization system in Japan ... sale in Japan in the latter ... and an extensive product portfolio in endoscopic surgery market in ...
Breaking Medicine Technology:Global Laboratory Electronic Balance Market 2014-2018: Key Vendors are A&D Company, Mettler-Toledo, Sartorius and Thermo Fisher 2Best Practices' Medical Affairs Consortium Survey Has Achieved Strong Participation 2MC Medical agrees to be the exclusive distributor of FloShield products in Japan 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: