Navigation Links
U of T researchers create microchip that can detect type and severity of cancer
Date:9/28/2009

TORONTO, ON UofT researchers have used nanomaterials to develop a microchip sensitive enough to quickly determine the type and severity of a patient's cancer so that the disease can be detected earlier for more effective treatment.

Their groundbreaking work, reported Sept. 27 in Nature Nanotechnology heralds an era when sophisticated molecular diagnostics will become commonplace.

"This remarkable innovation is an indication that the age of nanomedicine is dawning," says Professor David Naylor, president of the University of Toronto and a professor of medicine. "Thanks to the breadth of expertise here at U of T, cross-disciplinary collaborations of this nature make such landmark advances possible."

The researchers' new device can easily sense the signature biomarkers that indicate the presence of cancer at the cellular level, even though these biomolecules genes that indicate aggressive or benign forms of the disease and differentiate subtypes of the cancer are generally present only at low levels in biological samples. Analysis can be completed in 30 minutes, a vast improvement over the existing diagnostic procedures that generally take days.

"Today, it takes a room filled with computers to evaluate a clinically relevant sample of cancer biomarkers and the results aren't quickly available," says Shana Kelley, a professor in the Leslie Dan Faculty of Pharmacy and the Faculty of Medicine, who was a lead investigator on the project and a co-author on the publication.

"Our team was able to measure biomolecules on an electronic chip the size of your fingertip and analyse the sample within half an hour. The instrumentation required for this analysis can be contained within a unit the size of a BlackBerry."

Kelley, along with engineering professor Ted Sargent a fellow lead investigator and U of T's Canada Research Chair in Nanotechnology and an interdisciplinary team from Princess Margaret Hospital and Queen's University, found that conventional, flat metal electrical sensors were inadequate to sense cancer's particular biomarkers. Instead, they designed and fabricated a chip and decorated it with nanometre-sized wires and molecular "bait."

"Uniting DNA the molecule of life with speedy, miniaturized electronic chips is an example of cross-disciplinary convergence," says Sargent. "By working with outstanding researchers in nanomaterials, pharmaceutical sciences, and electrical engineering, we were able to demonstrate that controlled integration of nanomaterials provides a major advantage in disease detection and analysis."

The speed and accuracy provided by their device is welcome news to cancer researchers.

"We rely on the measurement of biomarkers to detect cancer and to know if treatments are working," says Dr. Tom Hudson, president and scientific director of the Ontario Institute for Cancer Research. "The discovery by Dr. Kelley and her team offers the possibility of a faster, more cost-effective technology that could be used anywhere, speeding up diagnosis and helping to deliver a more targeted treatment to the patient."

The team's microchip platform has been tested on prostate cancer, as described in a paper published in ACS Nano, and head and neck cancer models. It could potentially be used to diagnose and assess other cancers, as well as infectious diseases such as HIV, MRSA and H1N1 flu.

"The system developed by the Kelley/Sargent team is a revolutionary technology that could allow us to track biomarkers that might have significant relevance to cancer, with a combination of speed, sensitivity, and accuracy not available with any current technology," says Dr. Fei-Fei Liu, a radiation oncologist at Princess Margaret Hospital and Head of Applied Molecular Oncology Division, Ontario Cancer Institute. "This type of approach could have a profound impact on the future management for our cancer patients."


'/>"/>

Contact: April Kemick
april.kemick@utoronto.ca
416-978-0100
University of Toronto
Source:Eurekalert

Related medicine news :

1. Researchers believe hormone therapy should not be stopped prior to mammograms
2. McMaster researchers discover a new antibacterial lead
3. BUSM researchers propose a relationship between androgen deficiency and cardiovascular disease
4. UCI researchers create new strategy for highly selective chemotherapy delivery
5. UCI researchers create new strategy for highly-selective chemotherapy delivery
6. Pancreatic cancer: Researchers find drug that reverses resistance to chemotherapy
7. VA Honors Eye Researchers With Olin Teague Award
8. Researchers find drug-eluting stents safe, effective for PCI in diabetics
9. Researchers Propose Improved Cervical Cancer Screening
10. Researchers Perfect the View of Heart Disease
11. Mayo Clinic researchers lead national trial testing new treatment for chronic, severe indigestion
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... ... May 24, 2016 , ... Jericho Project has named LaToya Williams-Belfort to ... be responsible for fundraising and communications for the nationally-acclaimed nonprofit, working closely with CEO ... working to end homelessness at its roots. , “LaToya Williams-Belfort is joining Jericho ...
(Date:5/24/2016)... ... May 24, 2016 , ... How to Write Error ... NC, http://www.fdanews.com/humanerrordrugdevice , Human error is known to be the major cause ... error will ever be totally eliminated, many human performance problems can be prevented. , ...
(Date:5/24/2016)... ... May 24, 2016 , ... Loma Linda University Health (LLUH) has ... and expanded Children’s Hospital. Over 3,000 people looked on as the shovels hit the ... event photo slidehsow. , During the program, Richard H. Hart, MD, DrPH, president, ...
(Date:5/24/2016)... ... May 24, 2016 , ... Eggsurance, the first ... relaunch of its community and education hub for women considering fertility preservation, as ... create a safe and welcoming place for women to find cycle buddies, get ...
(Date:5/24/2016)... ... May 24, 2016 , ... Tuesday, May 24, Women's Excellence ... practice enhanced with Young Living Essential Oils, taught by Patti Dolan, RYT, a ... Orion location. Yoga Flow is 6:30pm - 7:15pm followed by a small intro to ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... --Diplomat Pharmacy, Inc. (NYSE: DPLO) announced today the start ... hands-on learning experience is a 12-week summer program, May ... and Internship programs bring participants to ... are provided optional housing free of charge through Diplomat ... Riverfront Residence Hall to foster communication and collaboration among ...
(Date:5/23/2016)... , May 23, 2016 ... Market Size, Share, Development, Growth and Demand Forecast ... Single and Other), by Application (Drug Discovery and ... End Users (Pharmaceuticals, Life Science and Biotechnology, Academic ... P&S Market Research, the global mass spectrometry ...
(Date:5/23/2016)... 2016 The World Health Organization (WHO) expanded the ... include adolescents aged 13 years, and above. Effective immediately, the ... adult and adolescent males in the 14 priority countries in ... the first male circumcision device to receive WHO Prequalification on ... Horowitz said: " The expanded use of ...
Breaking Medicine Technology: