Navigation Links
U of T Researchers uncover major source of evolutionary differences among species
Date:12/20/2012

University of Toronto Faculty of Medicine researchers have uncovered a genetic basis for fundamental differences between humans and other vertebrates that could also help explain why humans are susceptible to diseases not found in other species.

Scientists have wondered why vertebrate species, which look and behave very differently from one another, nevertheless share very similar repertoires of genes. For example, despite obvious physical differences, humans and chimpanzees share a nearly identical set of genes.

The team sequenced and compared the composition of hundreds of thousands of genetic messages in equivalent organs, such as brain, heart and liver, from 10 different vertebrate species, ranging from human to frog. They found that alternative splicing a process by which a single gene can give rise to multiple proteins has dramatically changed the structure and complexity of genetic messages during vertebrate evolution.

The results suggest that differences in the ways genetic messages are spliced have played a major role in the evolution of fundamental characteristics of species. However, the same process that makes species look different from one another could also account for differences in their disease susceptibility.

"The same genetic mechanisms responsible for a species' identity could help scientists understand why humans are prone to certain diseases such as Alzheimer's and particular types of cancer that are not found in other species," says Nuno Barbosa-Morais, the study's lead author and a computational biologist in U of T Faculty of Medicine's Donnelly Centre for Cellular and Biomolecular Research. "Our research may lead to the design of improved approaches to study and treat human diseases."

One of the team's major findings is that the alternative splicing process is more complex in humans and other primates compared to species such as mouse, chicken and frog.

"Our observations provide new insight into the genetic basis of complexity of organs such as the human brain," says Benjamin Blencowe, Professor in U of T's Banting and Best Department of Research and the Department of Molecular Genetics, and the study's senior author.

"The fact that alternative splicing is very different even between closely related vertebrate species could ultimately help explain how we are unique."


'/>"/>

Contact: Nicole Bodnar
nicole.bodnar@utoronto.ca
416-978-5811
University of Toronto
Source:Eurekalert

Related medicine news :

1. MRIs reveal signs of brain injuries not seen in CT scans, UCSF/SFGH researchers report
2. Researchers find model system to study promising cancer drug
3. UNC researchers discover how hepatitis C virus reprograms human liver cells
4. Mayo Clinic researchers identify enzyme linked to prostate cancer
5. Researchers identify role for protein linked to obesity, type 2 diabetes
6. CWRU School of Medicine researchers discover new molecule linked to late-stage breast cancer
7. GOOOAAALLL! What soccer can teach health researchers
8. UAlberta medical researchers discover new potential chemotherapy
9. 10 researchers receive EMBO Installation Grants
10. Keck School of Medicine of USC researchers find clue to how Hepatitis C virus harms liver
11. UAlberta medical researchers make key discovery in fight against Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice ... "Film editors can give their videos a whole new perspective by using the ... of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to ...
(Date:6/25/2016)... ... ... Austin residents seeking Mohs surgery services, can now turn to Dr. Jessica Scruggs ... for medical and surgical dermatology. , Dr. Dorsey brings specialization to include Mohs surgery, ... Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn Goldstein, MD, ...
(Date:6/25/2016)... ... 25, 2016 , ... Dr. Calvin Johnson has dedicated his ... implemented orthobiologic procedures as a method for treating his patients. The procedure is ... to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use to help ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle ... chronic pain and the benefits of holistic treatments, Serenity Recovery Center of ... Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- The vast majority of dialysis patients currently receive ... usually 3 times a week, with treatment times averaging ... equipment preparation and wait time.  This regimen can be ... who are elderly and frail.  Many elderly dialysis patients ... for some duration of time. Residents in ...
(Date:6/23/2016)... 23, 2016  Experian Health, the healthcare ... the patient payment and care experience, today ... products and services that will enhance the ... offerings. These award-winning solutions will enable healthcare ... compliant in an ever-changing environment and redefine ...
(Date:6/23/2016)...  The National Pharmaceutical Council (NPC) today announced ... research organization as its newest member.  ... president and chief scientific officer, Mallinckrodt Pharmaceuticals, will ... Board of Directors. ... us in support of our efforts to conduct ...
Breaking Medicine Technology: