Navigation Links
U of Minn researchers discover genetic cancer link between humans and dogs
Date:2/28/2008

Cancer researchers at the University of Minnesota and North Carolina State University have found that humans and dogs share more than friendship and companionship they also share the same genetic basis for certain types of cancer. Furthermore, the researchers say that because of the way the genomes have evolved, getting cancer may be inevitable for some humans and dogs.

Jaime Modiano, V.M.D., Ph.D., University of Minnesota College of Veterinary Medicine and Cancer Center, and Matthew Breen, Ph.D., North Carolina State Universitys Center for Comparative Medicine and Translational Research, collaborated on this research study. Their findings are published in the current issue of the journal Chromosome Research, a special edition on comparative cytogenetics and genomics research by scientists from around the world.

Genomes are divided into chromosomes, which act as natures biological filing cabinets with genes located in specific places.

Many forms of human cancer are associated with specific alterations to the number or structure of chromosomes and the genes they contain, Breen said. We have developed reagents to show that the same applies to dog cancers, and that the specific genome reorganization which occurs in comparable human and canine cancers shares a common basis.

More specifically, Breen and Modiano found that the genetic changes that occur in dogs diagnosed with certain cancers of the blood and bone marrow, including chronic myelogenous leukemia (CML), Burkitts lymphoma (BL), and chronic lymphocytic leukemia (CLL), are virtually identical to genetic abnormalities in humans diagnosed with the same cancers.

We believe the implication of this finding is that cancer may be the consequence of generations of genetic evolution that has occurred similarly in dogs and humans, Modiano said. This means that to some degree, cancer may be inevitable in some humans and dogs just because of the way our genomes have developed since the separation from a common ancestor.

Since we know now that dogs and humans seem to share a common pathogenetic basis for some cancers, we believe that studying dog cancers may allow us to identify cancer-associated genes more easily in dog populations than in human populations. Once identified, we may be able to translate these findings to human cancers as we seek to provide a greater level of insight into cancer risk, diagnosis, and prognosis, said Modiano.

According to Breen and Modiano, dogs are good research subjects because they develop the disease spontaneously, and many of the modern breeds have developed over the past few hundred years using restricted gene pools. This selective breeding has preserved the genetics of a breed. It has also made some breeds more susceptible to certain cancers. These factors, coupled with the high degree of similarity between the genomes of dogs and humans, provided the researchers with an opportunity to compare the genomes and study the evolutionary genetic changes associated with cancer.

The human genome has 46 chromosomes and the dog genome contains 78 chromosomes. Sometimes, in the normal duplication process of cells, chromosomes can become rearranged or relocated. This rearrangement or relocation is called translocation. It can lead to a cell losing its normal function, becoming abnormal, and possibly developing into cancer.

Interestingly, we found that the same translocation of chromosomes happens in dogs as in humans for the three blood and bone marrow cancers we studied, Modiano said.

Breen and Modiano conclude that despite millions of years of divergence, the evolving genomes of dogs and humans seem to have retained the mechanism associated with cancer, and that the conserved changes in the genomes have similar consequences in dogs and humans.

Like ourselves, our pet dogs suffer from a wide range of spontaneous cancers. For thousands of years humans and dogs have shared a unique bond. In the 21st century this relationship is now strengthened to one with a solid biomedical basis; the genome of the dog may hold the keys to unlocking some of natures most intriguing puzzles about cancer, Breen said.

The next step for Breen and Modiano is to use grants received from the National Cancer Institute to start pinpointing risk factors for cancer in various breeds of dogs.


'/>"/>

Contact: Sara E. Buss
buss@umn.edu
612-626-7037
University of Minnesota
Source:Eurekalert  

Related medicine news :

1. New genetic association with schizophrenia found by researchers
2. Thomson Scientific To Honor Australias Top Researchers With Dedicated Australian Research Day
3. This is your brain on jazz: researchers use MRI to study spontaneity, creativity
4. First look: Princeton researchers peek into deepest recesses of human brain
5. U of Minn researchers find primary alcohol prevention programs are needed for tweens
6. Researchers collaborate to find new vaccine technology decreases E. coli in beef cattle
7. Researchers identify and shut down protein that fuels ovarian cancer
8. Implementers, Advocates, Researchers Call on Congress to Honor Lantos Commitment to Public Health and Human Rights by Placing Evidence over Ideology
9. Penn researchers engineer first system of human nerve-cell tissue
10. LSU researchers study coastal community bounce back
11. University of Sydney researchers find new evidence linking kava to liver damage
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
U of Minn researchers discover genetic cancer link between humans and dogs
(Date:10/13/2017)... ... 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills is proud ... and unique items from across the nation, this holiday-themed event will raise funds and ... the VNA. The boutique will be open Saturday, November 4 (10:00 a.m. – ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House ... most popular and least understood books in the Holy Scriptures, Revelation. The Book of ... baffled scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl ...
(Date:10/13/2017)... ... ... Journey: From the Mountains to the Mission Field”: the story of a missionary couple ... From the Mountains to the Mission Field” is the creation of published author, Carole ... and currently teaches a class of ladies at her church, which she has taught ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 ... characterized by frequent cessation in breathing. Oral appliances can offer significant relief to ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( ... today the introduction of an innovative new design of the shoulder pad. The ... get maximum comfort while controlling your pain while using cold therapy. By utilizing ice ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... 10, 2017   West Pharmaceutical Services, Inc. ... injectable drug administration, today shared the results of a ... improving the intradermal administration of polio vaccines. The study ... in May 2017 by Dr. Ondrej Mach , ... Health Organization (WHO), and recently published in the journal ...
(Date:10/4/2017)... Mass. , Oct. 4, 2017  According to the Centers for ... the end of October . PhysicianOne Urgent Care is helping communities across ... Westchester, NY , by offering no-cost* flu shots through the ... as mandated by certain health insurance regulations. ... The best time to get a flu shot is by the ...
(Date:10/2/2017)... 2017  AllianceRx Walgreens Prime, the combined central specialty ... pharmacy benefit manager Prime Therapeutics LLC (Prime), today officially ... the unveiling of new signage at its headquarters in ... at a few other company-owned facilities across the country. ... some of whom will begin to see the AllianceRx ...
Breaking Medicine Technology: