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U of M researchers using salmonella to fight cancer
Date:3/9/2011

could think of IL-2 as a guard dog that sniffs around looking for threats inside the body." he said. When it finds one, it calls in an attack by the immune system.
  • Researchers knew if they could make IL-2 near tumors, it would identify the cancerous cells as a threat and trigger an immune response near the tumor.
  • Salmonella naturally finds its way to a person's gut and associated tissues. Salmonella also naturally likes to grow inside of tumor cells. Hence, if you're looking for ways to treat cancer in the bowels, the nearby lymph nodes or the liver - salmonella is a perfect method to deliver a package of IL-2.

    In a nutshell, by using genetically modified salmonella packaged with IL-2, Medical School researchers have created a kind of two-prong attack on cancer the immune response called in by IL-2, and the salmonella itself. The therapy is administered simply mixed with a few ounces of water and imbibed orally.

    "This probably won't replace other ways of treating cancer such as chemotherapy and radiation," Greeno said. "But it's a promising area of study and we hope it can be a potent tool in our battle against cancer. It also has potential to be a much cheaper and less toxic alternative to chemotherapy and radiation."


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  • Contact: Nick Hanson
    hans2853@umn.edu
    612-624-2449
    University of Minnesota
    Source:Eurekalert

    Page: 1 2

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