Navigation Links
U of M researchers identify process that may help treat Parkinson's, spinal cord injuries
Date:4/16/2008

MINNEAPOLIS / ST. PAUL (April 16, 2008) A new discovery by University of Minnesota researchers may lead to a better understanding of how the spinal cord controls how people walk. These insights could help lead to treatments for central nervous system maladies such as Parkinson's disease and spinal cord injuries.

The study, headed by Joshua Puhl, Ph.D., and Karen Mesce, Ph.D., in the Departments of Entomology and Neuroscience, discovered its possible that the human nervous system within each segment or region of spinal cord may have its own unit burst generator to control rhythmic movements such as walking.

By studying a simpler model of locomotion, in the medicinal leech, the research shows where these unit burst generators reside and that each nerve cord segment has a complete generator. When a neuron fires, it sets off a chain reaction that gives rise to rhythmic movement. Once those circuits are turned on, the body essentially goes on autopilot.

Mesce and her research group targeted the segmented leech for study because they have fewer and larger neurons making them easier to study.

The study was published today online in the Journal of Neuroscience.

For most of us, we can chew gum and walk at the same time, Mesce said. We do not have to remind ourselves to place the right leg out first, bring it back and do the same for the other leg. So how does the nervous system control rhythmic behaviors like walking or crawling"

Furthermore, and perhaps just as important, the study found that dopamine a common human hormone can turn each of these complete generator units on.

Since dopamine regulates movements and activates those unit burst generators, the next step will be figuring out how dopamine makes individual neurons more or less active.

Because dopamine affects movement in many different animals, including humans, our studies may help to identify treatments for Parkinsons patients and those with spinal cord injury, Mesce said.


'/>"/>

Contact: Nick Hanson
hans2853@umn.edu
612-624-2449
University of Minnesota
Source:Eurekalert

Related medicine news :

1. OHSU Cancer Institute researchers discover key gene involvement in cancer development
2. Combining liver cancer treatments doubles survival rates, UVA researchers find
3. Leading HIV researchers to collaborate on vaccine development
4. Georgetown researchers find stem cell marker controls 2 key cancer pathways
5. Blood pressure drugs halt pancreatic cancer cell growth, Jefferson researchers find
6. OHSU Cancer Institute researchers find connection between protein, prognosis in breast cancer
7. Karmanos Researchers Report Enhanced Chemosensitivity of Pancreatic Cancer Cells by Black Seed Component
8. Penn researchers find targeted therapy combination overcomes treatment resistance in liver cancer
9. Researchers find disparities in depression among older Hispanics in US
10. Researchers Identify New Genetic Links to Psoriasis
11. Penn researchers discover modus operandi of heart muscle protein
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... ... 2016 , ... PharmMD CEO Robert Yeager announced ... on contract negotiations, corporate strategy and healthcare data law. Additional responsibilities will include ... data breaches for the Part D Star Rating improvement and Medication Therapy Management ...
(Date:2/11/2016)... ... 11, 2016 , ... AccuVein Inc. announces the Infusion Nurses ... Practice, to include vascular visualization as a standard practice. AccuVein ( http://www.accuvein.com ), ... market, facilitates adherence to this standard with its easy to use, widely deployed ...
(Date:2/11/2016)... ... , ... The annual list showcases the 20 Most Promising SharePoint Solution Providers ... and commitment to the SharePoint ecosystem. A panel of experts and members of CIOReview’s ... recognize and promote technology entrepreneurship. , The survey was made at the end ...
(Date:2/11/2016)... ... February 11, 2016 , ... Hoggan Scientific, LLC, ... used in physical therapy, occupational therapy and sports medicine clinics, hospitals, universities and ... and therapy, introduces its new microFET Digital Pinch Gauge. , Hoggan Scientific ...
(Date:2/11/2016)... ... February 11, 2016 , ... Research led ... rates of several common cancer screenings, especially among women. Cancer screenings are often ... rates. , The study,“What Does Medicaid Expansion Mean for Cancer Screening and ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... , Feb. 11, 2016  MiMedx Group, Inc. ... utilizing human amniotic membrane and other birth tissues, human ... to develop and market advanced products and therapies, announced ... Markets, 2016 Global Healthcare Conference in New ... and CEO, Michael J. Senken , Chief Financial ...
(Date:2/11/2016)... PORTLAND, Ore. , Feb. 11, 2016 ... to announce the acquisition of SolutionsRx, a full-service 340B ... hospitals. Along with providing traditional contract pharmacy services, SolutionsRx ... assist clients in navigating the complex 340B regulatory environment. ... Wellpartner. --> James R. Love , CEO ...
(Date:2/11/2016)... , Feb. 11, 2016  Proliant Biologicals is proud ... Serum Albumin (BSA) manufacturing facility.  The facility is located ... , in Feilding. Boone ... to functionally duplicate the systems in the U.S. facility, ... used for U.S. installations.  --> ...
Breaking Medicine Technology: