Navigation Links
U of M researchers identify key proteins influencing major immune strategies
Date:10/28/2013

MINNEAPOLIS/ST. PAUL (October 27, 2013) New research from the Masonic Cancer Center, University of Minnesota, and the University of Minnesota Center for Immunology has identified key proteins that influence immune response strategies, a finding that could influence new vaccination approaches.

The study, published in the latest edition of Nature Immunology, looked closely at the KLF2 and S1P1 genes, and how their expression impacted the immune strategy of a cell.

The immune system has two main strategies to empower white blood cells, or lymphocytes, to resist infections of the body.

The first strategy, called recirculation, is a process where white blood cells are carried around in circulating blood, allowing rapid access to organs once an immune response has begun.

The second major strategy allows lymphocytes to migrate into tissues and remain there long-term, creating a kind of rapid response team to any infectious organism that enters the body. These cells are called resident memory T-cells or Trm, and they play a dominant role in initiating immune responses that control infections.

"A key question we had was how lymphocytes make the choice to be a recirculator or a resident," said Stephen Jameson, Ph.D., a professor in the Center for Immunology and Department of Laboratory Medicine and Pathology in the University of Minnesota Medical School. "We already knew the protein KLF2 regulates the expression of genes. One of those genes, called S1P1, allows lymphocytes to leave tissues and begin recirculating."

Intrigued by the impact of KLF2 and S1P1 on lymphocytes' ability to move out of tissues, Jameson and colleagues wanted to compare resident and recirculating cells and the KLF2 and S1P1 levels. They found that resident T-cells had lost expression of the KLF2 and S1P1 genes.

The next step was finding what controlled the expression of KLF1 and S1P1. Jameson's team was able to pinpoint cytokines as playing a major role in this cell decision-making process.

"Cytokines are soluble proteins that act similar to hormones for the immune system," said Jameson. "We found the cytokines can instruct cells to become resident memory cells, thereby may be useful for bolstering local immunity."

Though further research is needed to define the biochemical signals dictating how recirculation versus residency is chosen, learning more about these key signals instructing T-cells to determine their strategic immunity role could significantly improve vaccination approaches. Researchers may be able to use the knowledge and develop technology to focus memory T-cells to form a barrier to infections.


'/>"/>

Contact: Caroline Marin
crmarin@umn.edu
612-624-5680
University of Minnesota Academic Health Center
Source:Eurekalert

Related medicine news :

1. Researchers detail possible resistance mechanisms of colorectal cancer to bevacizumab (Avastin)
2. Carnegie Mellon and University at Buffalo researchers improving transit for people with disabilities
3. Researchers discover a new protein fold with a transport tunnel
4. Mount Sinai Researchers Identify Mechanisms and Potential Biomarkers of Tumor Cell Dormancy
5. Study by researchers at Saarland University demonstrates preventive effect of sterols in Alzheimers
6. Neurotoxin effectively relieves bone cancer pain in dogs, Penn researchers find
7. Mount Sinai Researchers Find Value -- and Limitations -- of Patient Assistance Programs for Women with Breast Cancer
8. Researchers propose social network modeling to fight hospital infections
9. BUSM researchers make a case for free fatty acids
10. Researchers launch first-ever phase II safety study of rectal microbicide to prevent HIV
11. CWRU researchers probe brain implant failure and countermeasure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... 2016 , ... On June 10-11, 2016, A Forever Recovery, a holistic treatment ... Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. This ... of the world’s leading providers of cereal and other breakfast foods. Its residents often ...
(Date:6/26/2016)... ... June 26, 2016 , ... ... they have been diagnosed with endometriosis. These women need a treatment plan to ... a comprehensive approach that can help for preservation of fertility and ultimately achieving ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX ... Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over ... Cut Pro X . Simply select a ProHand generator and drag it above media ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of ... recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at Work ... Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 , , , ... 7, 2016 , , , , LOCATION: , , , ... , , , EXPERT PANELISTS:  , , , Frost & Sullivan,s ... Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program ... global pharmaceutical industry is witnessing an exceptional era. Several new demand ...
(Date:6/23/2016)... PRINCETON, N.J. , June 23, 2016  Guerbet ... of Premier Inc.,s Supplier Horizon Award . ... this year, Guerbet was recognized for its support of ... value creation through clinical excellence, and commitment to lower ... delighted to receive this recognition of our outstanding customer ...
(Date:6/23/2016)... NEW YORK , June 23, 2016 ... rough waters, but it continues to present great opportunities ... featured companies for today: Intrexon Corp. (NYSE: ... ), Arena Pharmaceuticals Inc. (NASDAQ: ARNA ), ... Learn more about these stocks and receive your complimentary ...
Breaking Medicine Technology: