Navigation Links
U of M researchers identify key proteins influencing major immune strategies

MINNEAPOLIS/ST. PAUL (October 27, 2013) New research from the Masonic Cancer Center, University of Minnesota, and the University of Minnesota Center for Immunology has identified key proteins that influence immune response strategies, a finding that could influence new vaccination approaches.

The study, published in the latest edition of Nature Immunology, looked closely at the KLF2 and S1P1 genes, and how their expression impacted the immune strategy of a cell.

The immune system has two main strategies to empower white blood cells, or lymphocytes, to resist infections of the body.

The first strategy, called recirculation, is a process where white blood cells are carried around in circulating blood, allowing rapid access to organs once an immune response has begun.

The second major strategy allows lymphocytes to migrate into tissues and remain there long-term, creating a kind of rapid response team to any infectious organism that enters the body. These cells are called resident memory T-cells or Trm, and they play a dominant role in initiating immune responses that control infections.

"A key question we had was how lymphocytes make the choice to be a recirculator or a resident," said Stephen Jameson, Ph.D., a professor in the Center for Immunology and Department of Laboratory Medicine and Pathology in the University of Minnesota Medical School. "We already knew the protein KLF2 regulates the expression of genes. One of those genes, called S1P1, allows lymphocytes to leave tissues and begin recirculating."

Intrigued by the impact of KLF2 and S1P1 on lymphocytes' ability to move out of tissues, Jameson and colleagues wanted to compare resident and recirculating cells and the KLF2 and S1P1 levels. They found that resident T-cells had lost expression of the KLF2 and S1P1 genes.

The next step was finding what controlled the expression of KLF1 and S1P1. Jameson's team was able to pinpoint cytokines as playing a major role in this cell decision-making process.

"Cytokines are soluble proteins that act similar to hormones for the immune system," said Jameson. "We found the cytokines can instruct cells to become resident memory cells, thereby may be useful for bolstering local immunity."

Though further research is needed to define the biochemical signals dictating how recirculation versus residency is chosen, learning more about these key signals instructing T-cells to determine their strategic immunity role could significantly improve vaccination approaches. Researchers may be able to use the knowledge and develop technology to focus memory T-cells to form a barrier to infections.


Contact: Caroline Marin
University of Minnesota Academic Health Center

Related medicine news :

1. Researchers detail possible resistance mechanisms of colorectal cancer to bevacizumab (Avastin)
2. Carnegie Mellon and University at Buffalo researchers improving transit for people with disabilities
3. Researchers discover a new protein fold with a transport tunnel
4. Mount Sinai Researchers Identify Mechanisms and Potential Biomarkers of Tumor Cell Dormancy
5. Study by researchers at Saarland University demonstrates preventive effect of sterols in Alzheimers
6. Neurotoxin effectively relieves bone cancer pain in dogs, Penn researchers find
7. Mount Sinai Researchers Find Value -- and Limitations -- of Patient Assistance Programs for Women with Breast Cancer
8. Researchers propose social network modeling to fight hospital infections
9. BUSM researchers make a case for free fatty acids
10. Researchers launch first-ever phase II safety study of rectal microbicide to prevent HIV
11. CWRU researchers probe brain implant failure and countermeasure
Post Your Comments:
(Date:11/25/2015)... ... ... For the first time, Vitalalert is donating half of its earnings to ... between the two groups began in 2014 with Vitalalert pledging a portion of every ... founded in 1954 and is an international Christian-based health organization whose mission is to ...
(Date:11/25/2015)... ... November 25, 2015 , ... On November 25, 2015, ... for the Narconon network, announced the release of a new cutting edge recovery program ... organization has been working with drug- and alcohol-addicted individuals with the purpose to free ...
(Date:11/25/2015)... ... ... Smiles by Stevens is pleased to announce the addition of Botox® for ... aware of the benefits of Botox® in the treatment of moderate facial wrinkling, few ... and pain as a result of Jaw Tension, TMJ (temporo-mandibular joint) disorder, and Bruxism ...
(Date:11/25/2015)... ... , ... In an ongoing Clinical Study conducted by an independent physician, Andrew ... is evaluating the efficacy of its product and its disinfection protocol. This study is ... May 2014 through October 2015 at a 360-bed, acute-care, academic medical center located in ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... the nation’s Periwinkle Pioneers, individuals and groups responsible for advancing care for pulmonary ... Periwinkle Pioneers, nominated by the public, will receive special recognition throughout 2016 as ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... -- Allergan plc (NYSE: AGN ) today announced that ... York State Attorney General,s Office to end the ... statutes with the Attorney General over the decision of Forest ... selling the now generic version of memantine immediate release tablets.  ... released its counterclaims against New York , ...
(Date:11/25/2015)... -- Allergan plc (NYSE: AGN ), a ... start-up  biotechnology company focused on the development of ... by the F-Prime Biomedical Research Initiative (FBRI), today ... collaboration to support the discovery and development of ... Obsessive Compulsive disorders (OCD). ...
(Date:11/25/2015)... 2015 --> ... devices was valued at $11,171.1 million in 2014, and ... 5.7% during 2015 - 2022. The global market is ... of diabetes. In addition, the increase in obese population ... to the growth of the market. Furthermore, technological advancements ...
Breaking Medicine Technology: