Navigation Links
U of M researchers find cerebral malaria may be a major cause of brain injury in African children
Date:7/29/2008

Researchers at the University of Minnesota have found that cerebral malaria is related to long-term cognitive impairment in one of four child survivors. The research is published in the current issue of the journal Pediatrics.

Malaria is a leading cause of death for children in sub-Saharan Africa. Cerebral malaria, which affects more than 750,000 children a year, is one of the deadliest forms of malaria. It only takes one bite from an infected mosquito to contract the disease that directly affects the brain, causing fever, vomiting, chills, and coma.

"Children with cerebral malaria recover quite dramatically if they survive the period of coma," said Chandy John, M.D., associate professor of pediatrics at the University of Minnesota and principal investigator of the study. "But before this study, no one had prospectively assessed what happened to their thinking in the years after they had the cerebral malaria episode."

John worked with Michael Boivin, Ph.D., M.P.H., an expert in neuropsychology from Michigan State University, to evaluate cognitive function in children 5-12 years old with cerebral malaria who had been admitted to the Mulago Hospital, Kampala, Uganda. The children were evaluated for cognitive function in three major areas: attention, working memory, and tactile learning. Evaluation was done at hospitalization, six months after the initial malaria episode, and two years after the episode.

John and Boivin found that at six months, 21 percent of children with cerebral malaria had cognitive impairment compared with 6 percent of their healthy Ugandan peers. At two years, cognitive impairment was present in 26 percent of the patients, compared with 8 percent of the community children. These findings suggest that cognitive impairment may begin to manifest itself months after the initial episode. Cognitive function was most dramatically impaired in the area of attention. "The study has major public health implications," John noted. "If 26 pecent of children with cerebral malaria have long-term cognitive impairment, which means more than 200,000 children a year may have significant long-term brain injury because of cerebral malaria."

John and Boivin are currently conducting a new study in Uganda to look at how the body's response to malaria infection may be leading to brain injury. "If we can determine what is causing the brain injury, we can design and test interventions to prevent the injury," John said.


'/>"/>

Contact: Kayla Kluver
kluve013@umn.edu
612-625-4119
University of Minnesota
Source:Eurekalert

Related medicine news :

1. Researchers Map Americas Deadliest Roads
2. Researchers disprove long-standing belief about HIV treatment
3. Teamwork cuts out unnecessary biopsies, researchers find
4. Researchers probe geographical ties to ALS cases among 1991 Gulf War veterans
5. Montreal researchers prove that insulin-producing cells can give rise to stem-like cells in-vitro
6. Researchers Find Link Between Organ Transplants, Cancer
7. Tufts researchers discover link between DNA palindromes and disease
8. Researchers hone technique to KO pediatric brain tumors
9. Researchers link Huntingtons disease to overactive immune response in the brain
10. Researchers: Program discourages HIV transmission in Russia
11. Stanford Bio-X researchers use needle-thin probe to get first look at working muscle fiber
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, ... Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms ... Final Cut Pro X . Simply select a ProHand generator and drag it above ...
(Date:6/25/2016)... ... 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his ... David Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps ... in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van ... Wellness at Work award to iHire in recognition of their exemplary accomplishments in worksite ... 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum ...
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle ... chronic pain and the benefits of holistic treatments, Serenity Recovery Center of ... Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Consumers have taken a more ... placed more emphasis on patient outcomes. ... in the pharmaceutical industry have evolved beyond just ... companies are focusing on becoming more patient-oriented across ... and services that improve health. ...
(Date:6/24/2016)... , June 24, 2016 ... of the "Structural Electronics 2015-2025: Applications, Technologies, ... In-Mold Electronics, Smart Skin, ... Photovoltaics Structural electronics involves electronic ... load-bearing, protective structures, replacing dumb structures such as ...
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
Breaking Medicine Technology: