Navigation Links
U of M researchers find cerebral malaria may be a major cause of brain injury in African children

Researchers at the University of Minnesota have found that cerebral malaria is related to long-term cognitive impairment in one of four child survivors. The research is published in the current issue of the journal Pediatrics.

Malaria is a leading cause of death for children in sub-Saharan Africa. Cerebral malaria, which affects more than 750,000 children a year, is one of the deadliest forms of malaria. It only takes one bite from an infected mosquito to contract the disease that directly affects the brain, causing fever, vomiting, chills, and coma.

"Children with cerebral malaria recover quite dramatically if they survive the period of coma," said Chandy John, M.D., associate professor of pediatrics at the University of Minnesota and principal investigator of the study. "But before this study, no one had prospectively assessed what happened to their thinking in the years after they had the cerebral malaria episode."

John worked with Michael Boivin, Ph.D., M.P.H., an expert in neuropsychology from Michigan State University, to evaluate cognitive function in children 5-12 years old with cerebral malaria who had been admitted to the Mulago Hospital, Kampala, Uganda. The children were evaluated for cognitive function in three major areas: attention, working memory, and tactile learning. Evaluation was done at hospitalization, six months after the initial malaria episode, and two years after the episode.

John and Boivin found that at six months, 21 percent of children with cerebral malaria had cognitive impairment compared with 6 percent of their healthy Ugandan peers. At two years, cognitive impairment was present in 26 percent of the patients, compared with 8 percent of the community children. These findings suggest that cognitive impairment may begin to manifest itself months after the initial episode. Cognitive function was most dramatically impaired in the area of attention. "The study has major public health implications," John noted. "If 26 pecent of children with cerebral malaria have long-term cognitive impairment, which means more than 200,000 children a year may have significant long-term brain injury because of cerebral malaria."

John and Boivin are currently conducting a new study in Uganda to look at how the body's response to malaria infection may be leading to brain injury. "If we can determine what is causing the brain injury, we can design and test interventions to prevent the injury," John said.


Contact: Kayla Kluver
University of Minnesota

Related medicine news :

1. Researchers Map Americas Deadliest Roads
2. Researchers disprove long-standing belief about HIV treatment
3. Teamwork cuts out unnecessary biopsies, researchers find
4. Researchers probe geographical ties to ALS cases among 1991 Gulf War veterans
5. Montreal researchers prove that insulin-producing cells can give rise to stem-like cells in-vitro
6. Researchers Find Link Between Organ Transplants, Cancer
7. Tufts researchers discover link between DNA palindromes and disease
8. Researchers hone technique to KO pediatric brain tumors
9. Researchers link Huntingtons disease to overactive immune response in the brain
10. Researchers: Program discourages HIV transmission in Russia
11. Stanford Bio-X researchers use needle-thin probe to get first look at working muscle fiber
Post Your Comments:
(Date:12/1/2015)... ... December 02, 2015 , ... ... events and association with initiation of treatment for osteoporosis ”. , As corresponding ... pharmacological treatment in patients diagnosed with osteoporosis. Based on a large US managed ...
(Date:12/1/2015)... ... December 01, 2015 , ... According to an article published ... discrimination claim against the U.S. Department of Health and Human Services, claiming that any ... plans are breaking the clause in the law prohibiting the denial of coverage for ...
(Date:12/1/2015)... ... December 01, 2015 , ... Dr. Paul Vitenas, one of ... has been named by MedEsthetics magazine as the Best Single Physician Practice in the ... the many elite aesthetic physicians honored by the industry publication. , Dr. Vitenas ...
(Date:12/1/2015)... NY (PRWEB) , ... December 01, 2015 , ... ... in the 1980s we have seen vast improvements in scientific research and discoveries, ... significant strides, providing increased hope and relief to those affected by HIV/AIDS. Mediaplanet’s ...
(Date:12/1/2015)... ... December 01, 2015 , ... Diabetic ... United States. Podiatrists are well aware that psychology-based patient non-compliance (disobedience of a ... catastrophic contributors to diseases of the diabetic foot. The American Board of ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... Dec. 1, 2015 Array BioPharma ... that its Chief Executive Officer, Ron ... Annual Healthcare Conference in New York.  The ... conference through a webcast on the Array ... , --> , ...
(Date:12/1/2015)... Dec. 1, 2015 Assurex Health, Inc. ... test giving healthcare providers an expanded range of ... patients suffering from depression, anxiety, bipolar disorder, posttraumatic ... conditions. i .   ... With the addition of two new drug classes, ...
(Date:12/1/2015)... 1, 2015 --> ... report "Nucleic Acid Labeling Market by Product (Reagents & ... Primer, In Vitro Transcription, Reverse Transcription, End Labeling), by ... The global market is expected to reach USD 1,925.7 ... growing at a CAGR of 8.65%. Browse ...
Breaking Medicine Technology: