Navigation Links
U of M researchers discover a pathway to turn off immune system cells
Date:1/31/2008

University of Minnesota researchers have discovered a new way to turn genes off in human T cells, a type of white blood cell that helps the immune system fight infections.

Turning off genes, through a process known as mRNA decay, is important for regulating the bodys immune response after fighting infection. This research could lead to development of new drugs that turn off the immune system in patients with autoimmune diseases such as rheumatoid arthritis and lupus. It could also prevent cancer cells from dividing.

Researchers used a novel approach that combines molecular biology and computational analysis to identify mRNA sequence responsible for turning off T cells. The research is published in the February 1 issue of Molecular Cell.

Although this study analyzed T cells, this pathway is present in all human cells, said Paul Bohjanen, M.D., Ph.D., co-director of the Center for Infectious Diseases and Microbiology Translational Research (CIDMTR) and principal investigator of the study. Knowledge from this study can be applied to help researchers better understand other types of cells and how they function.

During an infection, T cells turn on and divide to help clear the infection from the body. After the infection is cleared, the cells need to turn off so the body can return to a stable condition. If the cells do not turn off, however, they can cause damage to the body and can potentially develop into cancer cells.

This research is important because to date, understanding the mechanisms that turn off cells has not been very well understood.

Researchers measured the rate of mRNA decay for each of the approximately 6,000 genes in human T cells. That information was then analyzed by George Karypis, Ph.D., associate professor of computer science, and his colleagues at the Minnesota Supercomputing Institute, using complex computer programs to identify a sequence present in mRNA that was destroyed rapidly in the cell. Bohjanen and his colleagues performed molecular biology experiments to confirm that this sequence targets mRNA for destruction and was responsible for turning off genes in activated T cells.

This discovery would not have been possible without the interdisciplinary collaboration between molecular biologists and computer scientists, Bohjanen said. The collaboration between Bohjanen and Karypis was facilitated by Irina Vlasova, M.D., Ph.D., research associate in Bohjanens molecular biology laboratory, who received training in computational biology through a Minnesota Supercomputing Institute fellowship.


'/>"/>

Contact: Molly Portz
mportz@umn.edu
612-625-2640
University of Minnesota
Source:Eurekalert

Related medicine news :

1. Oregon researchers find trigger gene for muscle development
2. Researchers uncover more about how poxviruses evade the immune system
3. UCLA researchers discover biomarkers that predict lung cancer patient response to therapy
4. Penn researchers discover new target for preventing and treating flu
5. Researchers investigate links between prostate, cadmium, zinc
6. New nanotube findings by Stanford researchers give boost to potential biomedical applications
7. Researchers Map Paths Governing Neuron Function
8. Cold Spring Harbor Laboratory researchers race against time to save Tasmanian devils
9. Researchers at Peoria Pulmonary Associates to study airway bypass procedure for emphysema
10. Pain medicine meeting unites top researchers and clinicians
11. Researchers identify brains eureka circuitry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2016)... ... May 28, 2016 , ... May 26, 2016- In ... Arts Fighting Challenge with theme event of “K Warriors” on June 4, 2016 at ... , The event is sponsored and hosted by Shaolin Institute and sanctioned by ...
(Date:5/27/2016)... , ... May 27, 2016 , ... Two director-level employees ... YWCA Tribute to Women and Industry (TWIN) 2016 honorees. The award recognizes businesswomen ... For this year, Geri Boone, Director of the MLTSS (Managed Long-Term Services and Supports) ...
(Date:5/27/2016)... NY (PRWEB) , ... May 27, 2016 , ... ... casual readers, this installment is bolstered by inspiring human-interest stories, courtesy of awareness-driven ... tech within the industry, from leading advocates, associations and industry leaders such as ...
(Date:5/27/2016)... ... May 27, 2016 , ... ... students studying complementary medicine. Allison Outerbridge is this year’s Life University ... May 18 at the university’s Student Leadership Awards ceremony. , Outerbridge is approaching ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cabot Corporation, Pfizer, ... respirators, according to court documents and SEC filings. A jury has returned ... v. American Optical Corporation, Case No. BC588866, Los Angeles County, California. The jury ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... 27, 2016 Kitov ... focused on late-stage drug development, today announced the ... of pivotal batches required for registration of KIT-302 ... This follows Kitov,s announcement in December ... met its primary efficacy endpoint. "We ...
(Date:5/26/2016)... 2016 TARE (Transarterial Radio-embolization) ... Savings and Overall Decreased Use of Hospital ... international specialist healthcare company, has today announced the ... Meeting of ISPOR (International Society for Pharmacoeconomics and ... (HCC) using yttrium-90 glass microspheres is associated with ...
(Date:5/25/2016)... HILDEN , Deutschland und GERMANTOWN, ... Zusammenarbeit mit Therawis bedient ... Entscheidungen bei Brustkrebs   QIAGEN N.V. ... QIA) gab heute bekannt, eine Lizenz- und Entwicklungsvereinbarung ... prädiktiver Assays für die Onkologie eingegangen zu sein. ...
Breaking Medicine Technology: