Navigation Links
U of M researchers develop a molecular 'calcium sponge' to tackle heart failure
Date:2/10/2013

MINNEAPOLIS/ST. PAUL (February 10, 2013) Researchers at the University of Minnesota's Department of Integrative Biology and Physiology and the Lillehei Heart Institute have utilized molecular genetic engineering to optimize heart performance in models of diastolic heart failure by creating an optimized protein that can aid in high-speed relaxation similar to fast twitching muscles.

Within heart cells, calcium plays a major role in orchestrating normal heart pump function. However, in diastolic failure the calcium signaling process is slowed; calcium levels rise to the peak needed for the squeezing action of the heart but don't then drop quickly enough for an efficient relaxation period the condition known as diastolic heart failure.

University researchers were able to pinpoint a specific protein, parvalbumin which aids in high-speed relaxation of fast twitching muscles in nature and optimize it to become a calcium sponge for heart muscle. As a result, the optimized protein, ParvE101Q, soaks up excess calcium at a precise instant, allowing the heart to relax efficiently after contraction.

The advance offers a solid conceptual step forward in solving the puzzle of diastolic heart failure. The next step will be determining the best possible small molecule or gene delivery mechanism for the protein, which should allow the discovery to be used in clinics.

Their approach is outlined in the latest issue of Nature Medicine.

"In nature, there are unique organisms known to be able to contract and relax muscles quickly," said Joseph M. Metzger, Ph.D., a University of Minnesota Medical School professor and chair of the Department of Integrative Biology and Physiology. "We hoped research and discovery could help identify what was promoting this highly efficient activity so we could harness it for use in the heart. We've discovered that our optimized variation of parvalbumin can fulfill that role by treating diastol
'/>"/>

Contact: Caroline Marin
crmarin@umn.edu
612-624-5680
University of Minnesota Academic Health Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UIC researchers to study how young adults use e-cigarettes, snus
2. Cancer Drug Doesnt Speed Up Tumor Growth, Researchers Say
3. UAB researchers cure type 1 diabetes in dogs
4. University of Minnesota researchers discover enzyme behind breast cancer mutations
5. Yale researchers spot attention deficits in babies who later develop autism
6. Researchers use new molecular inhibitors to successfully hit difficult cancer target
7. Researchers discover mutations linked to relapse of childhood leukemia
8. Moffitt Cancer Center researchers develop automated breast density test linked to cancer risk
9. Leading researchers warn of brain drain as scientists struggle to find funding
10. Researchers Identify Involuntary Tobacco Smoke Exposure in Boston Public Housing Authority Residents with Salivary Cotinine Testing from Salimetrics.
11. Researchers help confirm value of flow-diverting device for most challenging aneurysms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/3/2015)... Fourroux Prosthetics, located at 6630 McGinnis Ferry Rd, ... opening with a ribbon cutting ceremony on Wednesday, June ... kind in the area, Fourroux Prosthetics will provide amputee ... use of patented advanced prosthetics CAD/CAM technology. ... states, “Our goal has always been to provide amputees ...
(Date:6/3/2015)... “ Scanalytics ” was featured on ... features the latest and coolest technology products available to ... of NewsWatch, conducted the review and shared with viewers ... in retail stores. , Tracking statistics in business is ... comes to retail this goes a step beyond revenue ...
(Date:6/3/2015)... Consulting Services is excited to announce their achievement in ... April 2006, they have made it a priority to ... every year they have worked diligently in surpassing this ... they are off to a great start already for ... is the Customer Review site veatchconsultingreviews.weebly.com. At this site ...
(Date:6/2/2015)... June 02, 2015 Allred Dental, a dental ... for the months June-September, 2015 along with a $100 off ... limited time only. , “Sometimes wisdom teeth can be impacted, ... jawbone. They can also only partially break through the gum, ... recovery is easier in young people, as they do not ...
(Date:6/2/2015)... (PRWEB) June 02, 2015 Food Lion ... its sixth annual “Thriller on the Griller” events, starting ... and South Carolina locations. Each event will raise funds ... to restoring a sense of self, restoring the family ... our military families. , Through these events, Food ...
Breaking Medicine News(10 mins):Health News:Fourroux Prosthetics Atlanta to Have Grand Opening Gala & Ribbon Cutting Ceremony 2Health News:Technology to Analyze Foot Traffic in Retail Stores was featured on NewsWatch Television 2Health News:Veatch Consulting Services Is Breaking New Ground in Customer Satisfaction 2Health News:Veatch Consulting Services Is Breaking New Ground in Customer Satisfaction 3Health News:$100 Off Coupon for Wisdom Teeth Extractions Offered at Allred Dental 2Health News:Food Lion to Launch “Thriller on the Griller” Events to Benefit Military Families through Hope For The Warriors® 2Health News:Food Lion to Launch “Thriller on the Griller” Events to Benefit Military Families through Hope For The Warriors® 3
... Inc. (OTC Bulletin Board: SGTI) ("Shengtai" or "the ... grade,glucose products in China, today commented on a ... total of 850 billion RMB (USD 123 billion) ... the next three years,the multi-billion health care plan ...
... susceptibility, study says , , THURSDAY, Feb. 5 (HealthDay News) -- ... variant may affect a person,s risk of multiple sclerosis, according ... D deficiency while in the womb and early in life ... Both genetic and environmental factors play a role in MS, ...
... technology and cardiovascular diseaseHOUSTON, Feb. 5 "I salute ... No. 1 killer - cardiovascular diseases, including stroke. ... served as a clinical scientist and flight surgeon, I ... benefit medical and health care fields -- notably through ...
... 5 According to the Better Sleep,Council,s relationship expert ... help improve their relationship by catching extra,winks together in ... they,can,t sleep well side by side. , ... our mind and body, gives us energy,and improves our ...
... ATS Medical, Inc.,(Nasdaq: ATSI ), manufacturer ... announced today that the Australian Therapeutic Goods,Administration (TGA) ... Aortic Bioprosthesis. The Company looks forward to ... care for the Australian market. , ...
... spray when it was launched on the web in 2004. Now Sinus ... more than 5,000 Rite Aid drug stores. , ... Parsippany, NJ (PRWEB) February 5, 2009 ... pepper nasal spray in 2004 with a handful of sales on eBay. By ...
Cached Medicine News:Health News:Shengtai Pharmaceutical, Inc. Comments on China's Recently Approved Health Care Reform Plan 2Health News:Shengtai Pharmaceutical, Inc. Comments on China's Recently Approved Health Care Reform Plan 3Health News:Vitamin D Deficit May Trigger MS Risk Gene 2Health News:Coalition for Space Exploration Salutes American Heart Month 2Health News:Wake Up Your Relationship With a Good Night in Bed This Valentine's Day 2Health News:Wake Up Your Relationship With a Good Night in Bed This Valentine's Day 3Health News:Wake Up Your Relationship With a Good Night in Bed This Valentine's Day 4Health News:ATS Medical Announces Australian Regulatory Approval for ATS 3f Aortic Bioprosthesis 2Health News:ATS Medical Announces Australian Regulatory Approval for ATS 3f Aortic Bioprosthesis 3Health News:Sinus Buster Pepper Nasal Spray Moves Into Rite Aid Drug Stores 2
(Date:6/3/2015)...  (AHIP Institute Booth 1021) --  Availity , the ... a wide range of information to help health plans ... Health Insurance Plan,s (AHIP,s) 2015 Institute , June 3-5, ... Availity released a special report to AHIP Institute ... opportunities." The report identifies billions of dollars ...
(Date:6/3/2015)... MARLBOROUGH, Mass. , June 3, 2015 ... RXII ), a biotechnology company focused on ... the areas of dermatology and ophthalmology, today announced ... from the United States Patent and Trademark ... platform (sd‑rxRNA®). The patent, titled "RNA Interference ...
(Date:6/3/2015)... 3, 2015  EIP Pharma LLC ( www.eippharma.com ) ... development of VX-745 in Alzheimer,s disease (AD) is underway.  ... potent inhibitor of the alpha isoform of the protein ... "Recent human genetic data demonstrate that inflammation ... symptomatic Alzheimer,s, while the science also indicates the p38 ...
Breaking Medicine Technology:Availity to Share Insights, Tools and Strategies at AHIP 2015 to Enable Health Plans to Achieve Long-term, Sustainable Success in an Evolving Value-based Environment 2Availity to Share Insights, Tools and Strategies at AHIP 2015 to Enable Health Plans to Achieve Long-term, Sustainable Success in an Evolving Value-based Environment 3RXi Pharmaceuticals Granted Notice of Allowance for Patent Covering Lead Compound, RXI-109, for Use in the Eye 2RXi Pharmaceuticals Granted Notice of Allowance for Patent Covering Lead Compound, RXI-109, for Use in the Eye 3RXi Pharmaceuticals Granted Notice of Allowance for Patent Covering Lead Compound, RXI-109, for Use in the Eye 4EIP Pharma announces first patient dosing in phase 2 clinical studies of a novel brain-targeted anti-inflammatory drug candidate, VX-745, for the treatment of Alzheimer's disease (AD) 2EIP Pharma announces first patient dosing in phase 2 clinical studies of a novel brain-targeted anti-inflammatory drug candidate, VX-745, for the treatment of Alzheimer's disease (AD) 3
... InfuSystem Holdings, Inc. (NYSE MKT: INFU) ("InfuSystem" or ... related services, today announced that it received a letter ... Amex of the "record date" for the 2012 Annual ... the record date for the Company,s 2012 Annual Meeting, ...
... (NASDAQ: ROCM ) is pleased to announce an addition ... of the Magic3 Hydrophilic Intermittent Catheter with Coude Tip ... very latest Magic3 technology. It provides the ... designed curved tip configuration. The Coude tip is ...
Cached Medicine Technology:InfuSystem Holdings, Inc. Receives Letter From NYSE MKT Regarding Timely Notice Of Record Date For 2012 Annual Meeting Of Stockholders 2Rochester Medical Introduces Magic3® Coude Tip Hydrophilic Intermittent Catheter 2
4 mm x 9 mm tip....
Large. Double-ended. 3 mm pointed end and 5 mm angled end....
4 mm wide tip....
Double-ended. Blunt and semi sharp 5 mm tips. Designated most popular model or size....
Medicine Products: