Navigation Links
U of M researchers create beating heart in laboratory
Date:1/13/2008

MINNEAPOLIS / ST. PAUL (January, 13 2008) University of Minnesota researchers have created a beating heart in the laboratory.

By using a process called whole organ decellularization, scientists from the University of Minnesota Center for Cardiovascular Repair grew functioning heart tissue by taking dead rat and pig hearts and reseeding them with a mixture of live cells. The research will be published online in the January 13 issue of Nature Medicine.

The idea would be to develop transplantable blood vessels or whole organs that are made from your own cells, said Doris Taylor, Ph.D., director of the Center for Cardiovascular Repair, Medtronic Bakken professor of medicine and physiology, and principal investigator of the research.

Nearly 5 million people live with heart failure, and about 550,000 new cases are diagnosed each year in the United States. Approximately 50,000 United States patients die annually waiting for a donor heart.

While there have been advances in generating heart tissue in the lab, creating an entire 3-dimensional scaffold that mimics the complex cardiac architecture and intricacies, has always been a mystery, Taylor said.

It seems decellularization may be a solution essentially using natures platform to create a bioartifical heart, she said.

Decellularization is the process of removing all of the cells from an organ in this case an animal cadaver heart leaving only the extracellular matrix, the framework between the cells, intact.

After successfully removing all of the cells from both rat and pig hearts, researchers injected them with a mixture of progenitor cells that came from neonatal or newborn rat hearts and placed the structure in a sterile setting in the lab to grow.

The results were very promising, Taylor said. Four days after seeding the decellularized heart scaffolds with the heart cells, contractions were observed. Eight days later, the hearts were pumping.

Take a section of this
'/>"/>

Contact: Nick Hanson
hans2853@umn.edu
612-624-2449
University of Minnesota
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers challenge previous findings regarding widely used asthma treatment
2. UT Health Science Center researchers decoding saliva to detect breast cancer
3. Protein power: Researchers trigger insulin production in diabetic mice
4. Researchers use neuroimaging to study ESP
5. UGA researchers receive $9 million in grants to study barriers to effective addiction treatment
6. Researchers seek to make cavity-causing bacteria self-destruct
7. Human factors researchers test voting systems for seniors that can improve voting accuracy and speed
8. New research tools are too complex for easy answers, researchers say
9. In largest U.S. Hep C trial, researchers determine weight-based dosing is key to optimal treatment
10. U of M researchers discover fast-acting cyanide antidote
11. SLU researchers show how to stop muscle weakness caused by myasthenia gravis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2015)... ... September 02, 2015 , ... The 2015 ... day international investment and business conference will be hosted at five star Beijing ... The full-weekend networking conference will feature leading EB-5 industry professionals and Chinese private ...
(Date:9/2/2015)... ... September 02, 2015 , ... SonicSurg Innovations, ... market, announced today that more than 600 successful patient procedures have been performed ... Plus, nearly 70 of these procedures have been on triggering thumbs. , ...
(Date:9/2/2015)... ... ... On September 9, 2015, over 27,000 people from all over the world ... date for the state of Utah. , “We are thrilled with the overwhelming response ... doTERRA CEO. “One of the most exciting elements of our convention is the opportunity ...
(Date:9/2/2015)... (PRWEB) , ... September 02, 2015 , ... ... PAYROLL FITNESS" and will provide two days of payroll education covering legislative updates, ... technology changes. The speakers, which include representatives from Ceridian, Ultimate Software, the American ...
(Date:9/2/2015)... ... ... Dr. Robert G. Schwartz , the principal of Piedmont Physical Medicine ... martial art system that is also a philosophy of life that focuses on reducing ... to the 10th century, is a Russian Martial Art that has four key principles ...
Breaking Medicine News(10 mins):Health News:The 2015 China Overseas Investment and Entrepreneurship Summit (COIES) Announced 2Health News:Trigger Tome Surpasses 600 Successful Patient Procedures 2Health News:doTERRA to Host the Largest Single-Company Convention in the State of Utah 2Health News:23rd Annual NJ Statewide Payroll Conference in Vernon, NJ at the Minerals Hotel on October 15-16, 2015 2Health News:Dr. Robert G. Schwartz Achieves Certification in Russian Martial Art “Systema” and Focuses on Integrating Techniques & Principles into Health Care Delivery 2Health News:Dr. Robert G. Schwartz Achieves Certification in Russian Martial Art “Systema” and Focuses on Integrating Techniques & Principles into Health Care Delivery 3
... Today, Tuesday, January 27, 2009, 9:30 A.M.** Elected ... Community Based Health System for Embracing Courageous New Direction ... Accord Includes Free and Fair Union ... Conference to announce historic hospital accords. WHEN: Today, ...
... seize billions from state, construct prison health care centers ... lawsuit was filed this week to prevent a federal ... dollars from California,s treasury for the sole purpose of ... Safe Ventura County opposes the proposal to construct seven ...
... Fitness Industry Leader Champions Gupta,s Commitment to Enriching Quality ... 27 The American Council on Exercise (ACE), America,s ... fitness certification, education and training organizations in the world, ... Dr. Sanjay Gupta , chief medical correspondent for the ...
... (NYSE: SGP ) today reported that it ... study, a pivotal Phase III study in treatment-naive patients. ... III study in patients who failed prior treatment that ... enrolled its registration studies for boceprevir, its lead investigational ...
... (NYSE Alternext US: ILI) today announced that the Company has ... "Exchange") that outlines the Company,s strategy to regain compliance with ... Exchange to formally respond to the submitted plan within 45 ... able to continue its listing up to June 23, 2010 ...
... ANTHEM, Ariz., Jan. 27 Prime Companies, Inc. ... , The Company has begun receiving income ... , The web site is now accessible ... , , "These are major achievements and ...
Cached Medicine News:Health News:Caritas Christi, 1199SEIU, Area Trades Council to Announce Historic New Accord to Improve Health Care for Community, Patients, Health Workers 2Health News:Caritas Christi, 1199SEIU, Area Trades Council to Announce Historic New Accord to Improve Health Care for Community, Patients, Health Workers 3Health News:Caritas Christi, 1199SEIU, Area Trades Council to Announce Historic New Accord to Improve Health Care for Community, Patients, Health Workers 4Health News:Caritas Christi, 1199SEIU, Area Trades Council to Announce Historic New Accord to Improve Health Care for Community, Patients, Health Workers 5Health News:Caritas Christi, 1199SEIU, Area Trades Council to Announce Historic New Accord to Improve Health Care for Community, Patients, Health Workers 6Health News:Ventura County Taxpayers' Group Files Suit to Stop State-of-the-Art Hospitals for Incarcerated Felons 2Health News:American Council on Exercise (ACE) Endorses Appointment of Dr. Sanjay Gupta as Surgeon General of the United States 2Health News:Schering-Plough Completes Enrollment of Boceprevir Registration Studies in Treatment-Naive and Treatment-Experienced HCV Patients 2Health News:Schering-Plough Completes Enrollment of Boceprevir Registration Studies in Treatment-Naive and Treatment-Experienced HCV Patients 3Health News:Schering-Plough Completes Enrollment of Boceprevir Registration Studies in Treatment-Naive and Treatment-Experienced HCV Patients 4Health News:Schering-Plough Completes Enrollment of Boceprevir Registration Studies in Treatment-Naive and Treatment-Experienced HCV Patients 5Health News:Schering-Plough Completes Enrollment of Boceprevir Registration Studies in Treatment-Naive and Treatment-Experienced HCV Patients 6Health News:Schering-Plough Completes Enrollment of Boceprevir Registration Studies in Treatment-Naive and Treatment-Experienced HCV Patients 7Health News:Schering-Plough Completes Enrollment of Boceprevir Registration Studies in Treatment-Naive and Treatment-Experienced HCV Patients 8Health News:Interleukin Genetics' Submits Plan to Regain Compliance with Continued Listing Standards 2Health News:Prime Companies Revenue Stream Begins; Dentists in Every City and Town Available on Company's New Web Site 2
(Date:9/2/2015)... -- Research and Markets ( ... "Pharmaceutical Regulatory Affairs in the Middle East, ... conference to their offering. An Essential ... Particularly relevant for Pharmacovigilance, Regulatory Affairs, Clinical ... Regulatory Authorities Topics to be covered ...
(Date:9/2/2015)... The acute coronary syndrome (ACS) therapeutics market consists of ... While generic ACS drugs currently lead in market revenues, ... to more than 60 percent of the total market ... products between 2015 and 2019. The US market for ... driven primarily by incidence rates of ACS and the ...
(Date:9/1/2015)... Sept. 1, 2015 On August 31, 2015, ... , issued a 123-page order in the first of ... Conserve metal-on-metal hip replacement devices are defective.[1]  ... as to Plaintiff Robyn Christiansen,s claims for defective design, ... flatly rejected Wright Medical,s claim that the Medical Device ...
Breaking Medicine Technology:Pharmaceutical Regulatory Affairs Course in the Middle East, Dubai (Dubai, UAE - October 18-19, 2015) 2Branded Acute Coronary Syndrome Therapies to Grab Market Share from Generic Drugs Globally 2Branded Acute Coronary Syndrome Therapies to Grab Market Share from Generic Drugs Globally 3Pope McGlamry: Omnibus order in Conserve Hips MDL-2329 sets stage for bellwether trial 2Pope McGlamry: Omnibus order in Conserve Hips MDL-2329 sets stage for bellwether trial 3
... Calif., Oct. 12, 2011 Ultra Clean Holdings, Inc. (Nasdaq: ... critical subsystems for the semiconductor capital equipment, flat panel, medical, ... third quarter  2011 on Monday, October 24, 2011 after markets ... to discuss third quarter 2011 results and management,s outlook at ...
... LA JOLLA, Calif., Oct. 12, 2011 A ground-breaking ... McEvoy, for the Alzheimer,s Disease Neuroimaging Initiative, 2011, Predicting ... Neurology, epub ahead of print) compared the ability of ... dementia: i) degree of memory impairment,  ii) degree of ...
Cached Medicine Technology:NeuroQuant®, CorTechs Labs' FDA-Cleared System for Quantifying Regional Brain Atrophy from MRIs, Used to Identify Patients at Highest Risk for Developing Dementia 2
Expressions lets you change your eye color with lenses that offer incredible comfort and outstanding vision quality. Expression color lenses use a technologically advanced tinting process to produce ...
Modern, innovative and quick Intense Pulsed Light system. The Flash 1 is light and very compact, thus easily portable. Available in two different colors....
... for the physician who wishes to offer ... of clinical applications. The innovative cooled Nd:YAG ... treaent of deeper lying veins. The IPL ... and pigmented lesions, including IPL Skin Treaents ...
Available in Purple, orange, dark blue, yellow, gray, royal blue, green and light blue colors....
Medicine Products: