Navigation Links
U of M Masonic Cancer Center receives $26 million to lead national BMT cancer research
Date:9/21/2010

Two of the University of Minnesota Masonic Cancer Center's leading physician-scientists on research and treatment of cancers of the blood and bone marrow Philip McGlave, M.D., and Jeffrey Miller, M.D., -- have received renewed five-year program project research grants totaling almost $26 million from the National Cancer Institute (NCI).

McGlave and Miller will use the grants to lead research teams focused on increasing the availability, safety, and effectiveness of hematopoietic stem cell transplantation and cell therapies to improve treatment and survival for the thousand of patients diagnosed annually with leukemia, lymphoma, multiple myeloma and other blood and bone marrow disorders.

About the physician-scientists, their research goals

McGlave, deputy director of the Masonic Cancer Center and director of the University Medical School's Division of Hematology, Oncology, and Transplantation, received more than $12.6 million of renewed funding. He has received NCI funding to lead his stem cell research program for the past 15 years. The renewed funding will allow him to continue years 16-20 of his team's research, focusing on improving stem cell transplant and cell-based treatments.

Miller is associate director of the Masonic Cancer Center's Experimental Therapeutics Program and professor of medicine focusing on hematology, oncology, and transplantation. His award of more than $13.3 million will fund years 6-10 of his team's research on characterizing "natural killer cell" or "NK cells" to reduce the rate of relapse after transplant by leukemia patients. Currently, leukemia returns in about 25 percent of patients who undergo stem cell transplants.

In addition to University of Minnesota researchers, their respective research teams will include blood and marrow stem cell experts at the National Institutes of Health and at more than a dozen cancer research centers across the United States.

U of M pioneers stem cell transplantation

Stem cell transplant was pioneered at the University of Minnesota with the world's first successful donor transplant for malignant lymphoma performed in 1973. The patient was a 16-year old boy who is now 50 years old, married with a son, and living in the Twin Cities. Since then, hematopoietic cell transplantation has become a mainstay of treatment for blood and bone marrow cancers. The University of Minnesota through its Masonic Cancer Center has consistently maintained international leadership in stem cell transplant research and treatment.

Recent stem cell transplant research achievements

McGlave's research team most recently verified the effectiveness of umbilical cord blood transplants. Such transplants can be used in the majority of patients where a sibling is not available to serve as a stem cell donor. This finding now allows transplant physicians to identify donors for the majority of patients requiring hematopoietic cell transplants for treatment of hematologic cancers and diseases. Lead investigators on McGlave's team include University of Minnesota scientists Bruce Blazar, M.D., John Wagner, M.D., and Miller.

Achievements by Miller's research team include finding that favorable NK cell receptor genes in unrelated blood and marrow donors protect against relapse and provide significant relapse-free survival benefit to patients transplanted for treatment of acute myeloid leukemia. Lead investigators on Miller's team include Daniel Weisdorf, M.D., Sarah Cooley, M.D., and Chap Le, Ph.D., with Masonic Cancer Center; Peter Parham, Ph.D., Stanford University, Palo Alto, CA; Elizabeth Trachtenberg, Ph.D., The Children's Hospital Research Institute, Oakland, CA; Steven Marsh, Ph.D., Anthony Nolan Research, London, UK: and John Klein, Ph.D., Medical College of Wisconsin in Milwaukee.

Research to be conducted with new grants

Research projects McGlave and Miller's teams will undertake with the renewed funding include:

  • Conducting clinical trials to test the effectiveness of umbilical cord blood "T regulatory cells" (Tregs) to prevent graft-versus-host disease in transplant patients
  • Exploring the role of young stem cells in umbilical cord blood to restore the thymic epithelial cell function to prevent leukemia.
  • Leading clinical studies to determine the effect of NK cell therapy used in combination with transplant to reduce the leukemia and give the patient long-term survival.
  • Prospectively choosing donors for transplant based on favorable NK cell receptor genes.
  • Testing novel agents to better activate NK cells in the body.


'/>"/>

Contact: Nick Hanson
hans2853@umn.edu
612-624-2449
University of Minnesota
Source:Eurekalert

Related medicine news :

1. Rocketboy Media Wins Award for Masonic Lodge Web Site; Announces Signing of Several New Clients
2. War on cancer produces collateral damage to the heart
3. Cholesterol drug may have role in treating prostate cancer
4. Mayo-led researchers discover genetic variants modifying breast cancer risk
5. 4 possible risk factors for ovarian cancer found
6. 2 studies find new genetic links to ovarian cancer risk
7. New Drug Promising for Advanced Thyroid Cancer
8. Better marker for breast cancer may reduce need for second surgeries
9. Targeted therapy decreases progression rate in thyroid cancer
10. Prostate cancer community calls for better early detection and treatment
11. MIT researchers discover an unexpected twist in cancer metabolism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... Lori R. Somekh, founder of the Law Office of Somekh & ... and special needs planning attorneys. “Membership in ElderCounsel helps our office remain up to ... with elder law attorneys nationwide,” said Somekh. , ElderCounsel was founded ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids ... Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, ... run is geared towards children of all ages; it is a non-competitive, non-timed event, ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “America On The ... identity. “America On The Brink” is the creation of published author, William Nowers. ... great-grandchildren. As a WWII veteran, he spent thirty years in the Navy. ...
(Date:10/12/2017)... PALM CITY, Fla. (PRWEB) , ... October 12, 2017 , ... ... of cold therapy products, announced today the introduction of an innovative new design of ... the multipurpose pad so you get maximum comfort while controlling your pain while using ...
(Date:10/12/2017)... ... , ... HMP , a leader in healthcare events and education, today announced ... Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during the Eddie & Ozzie ... competition recognizes editorial and design excellence across a range of sectors. This year’s program ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017  AllianceRx Walgreens Prime, the ... by Walgreens and pharmacy benefit manager Prime Therapeutics LLC ... brand, which included the unveiling of new signage at ... as well as at a few other company-owned facilities ... brand to patients, some of whom will begin to ...
(Date:10/2/2017)... 2, 2017 The Rebound mobile app is poised ... reverse the tide of prescription drug addiction. The app empowers ... intake and stepping down their dosage in a safe, controlled ... December 2017; the first 100,000 people to sign up will ... http://www.rebound-solution.com/ ...
(Date:9/28/2017)... -- Cohen Veterans Bioscience and Early Signal Foundation announce ... home sensors for real-time monitoring of patients with trauma-related ... organization focused on disruptive health solutions for rare disorders ... to record and integrate behavioral, cognitive, physiological and contextual ... ...
Breaking Medicine Technology: