Navigation Links
U of I study shows benefits of hormone found in fat tissue
Date:2/26/2009

It's called the obesity paradox. Although obese people are more apt to suffer from inflammatory diseases, such as diabetes, heart disease, and stroke, they are also more likely to survive a major attack caused by one of those conditions.

University of Illinois scientists Gregory Freund and Christina Sherry shed light on the reasons for this phenomenon in a study in this month's issue of Endocrinology.

"Fat is a very complex and active tissueit has important functions beyond providing energy and insulating us from the cold," said Freund, a professor in the U of I College of Medicine's Department of Pathology and a faculty member in the U of I Division of Nutritional Sciences.

"We now know that leptin, a hormone secreted by fat tissue, plays a key role in regulating the immune system. When we exposed mice to hypoxia (simulating an event, such as a heart attack, in which a part of the body is deprived of oxygen), leptin triggered the immune system to increase production of an anti-inflammatory molecule, interleukin-1 receptor antagonist (IL-1RA)," he said.

"And, when we gave non-obese mice leptin injections, they recovered three times faster. Leptin did not hasten recovery though in IL-1RA knockout mice," Sherry said. That earlier work was published in a recent issue of Brain, Behavior, and Immunity.

In the Endocrinology study, one group of mice was fed a high-fat diet for 12 weeks (Sherry described this group as being in a mildly obese, pre-diabetic state), while another group was fed a normal diet. The obese mice recovered from acute hypoxia five times faster than the mice fed normal diets.

In a second experiment, Freund and Sherry examined macrophages (or immune cells) that were resident in peritoneal fat tissue from both groups of mice. In mice fed the high-fat diet, there was a very significant increase in IL-1RA as compared to mice fed the normal diet (330 pg vs.15 pg).

"Our
'/>"/>

Contact: Phyllis Picklesimer
p-pickle@uiuc.edu
217-244-2827
University of Illinois at Urbana-Champaign
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Federally-Funded Study Says Focus Should Be on Total Calories, Not Particular Foods
2. New Partnership for a Drug-Free America 20th Annual Study Shows Progress in Teens Recognizing Dangers of OTC Cough Medicine Abuse
3. The Catalyst Foundations Groundbreaking ACE Study-Based Services Bring Transformational Change to Healthcare
4. Want to Lose Weight? Just Eat Less, Diet Study Suggests
5. Study Pinpoints New Gene for Cystic Fibrosis
6. Study analyzes 2006 California heat waves substantial effect on morbidity
7. Study Shows Simple Measures May Help Prevent Sudden Death Event in Young Athletes
8. Million women study shows even moderate alcohol consumption associated with increased cancer risk
9. Cardiologists initiate STILETTO study to investigate treatment options for women with chest pain
10. National Lessons from State Health Reform: The Massachusetts Case Study
11. PSA Tests Not Race-Specific, Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2015)... Decora Preset 60 Minute Countdown Timer , a ... Hardware City.’ The product helps in automatically switching off any ... the related electronic device is automatically turned off after the ... said, “We are glad that this amazing product is now ... Timer Switch in just a few clicks. The product has ...
(Date:5/24/2015)... Michigan (PRWEB) May 24, 2015 ... them to take pressure measurements in patients’ bladder and ... doctor usually orders it if they have reported symptoms ... , Women’s Excellence in Bladder Control is ... unwanted urinary leakage or problems with overall control of ...
(Date:5/24/2015)... Indianapolis, Indiana (PRWEB) May 24, 2015 ... network service provider announces Midwest Telecom of America, Inc. ... , According to Cory Childs, IFN Enterprise Sales ... to service providers. “IFN’s fiber transport provides MTA ... Operations Center to their Tier 1 Internet and voice ...
(Date:5/23/2015)... 23, 2015 On May 13, Nithyananda ... a youngster's yogic power learned through meditation and initiation ... in Bangalore, India. , Yogamaatha, a nine-year-old girl from ... high profile professionals attending the 2015 Business Advocacy Summit ... -- blindfolded. , In a demonstration that lasted ...
(Date:5/23/2015)... Manufacturers are now required to produce water heaters ... Experts in the field agree that the regulation is aimed ... score is what miles per gallon is to your car. ... the minimum HSPF score has been raised to 8.2, technology ... north of 12. Indeed, the regulation was welcomed by environmentalist, ...
Breaking Medicine News(10 mins):Health News:Leviton's Decora 60 Minute Countdown Timer Available On ‘The Hardware City’ 2Health News:Indiana Fiber Network, LLC Enables Midwest Telecom of America with Fiber Route Diversity 2Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 2Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 3Health News:Parker & Sons Welcomes the Department of Energy’s Water Heater Regulation 2
... as Executive Vice President, Managing Director, NEW YORK, ... network, announced that Marcy Leger has joined the firm ... LM&P New,York, as a result of the tremendous growth ... President of Euro RSCG Life LM&P New,York and Chicago., ...
... NASA will release a,report on an astronaut and ... media teleconference to discuss the report at 2 ... an independent external committee,conduct a comprehensive review of ... NASA,s Johnson Space Center, Houston, began an internal,assessment ...
... Resources and National Association of Children of Alcoholics Offer ... Free Training Seminar for Clergy on January 30, 2008, ... and drug treatment agency and the National Association of ... others involved,in pastoral care with a free one-day training ...
... history, is determining factor, study finds , , TUESDAY, Jan. ... radiation treatment for fast-moving prostate cancer can save lives, ... have other serious medical problems, a new study shows. ... there definitely is a difference in outcome, depending on ...
... helps patients shed more pounds than dieting and exercise ... New research suggests that gastric lap-band surgery isn,t only for ... who aren,t severely fat. , Still, the surgery is extremely ... people with diabetes who need alternative ways to shed pounds, ...
... 22 STERIS Corporation,(NYSE: STE ) today announced ... dividend in the amount of $0.06 per common share. ... record at the close,of business on February 12, 2008., ... is to provide a healthier today and,safer tomorrow through ...
Cached Medicine News:Health News:Euro RSCG Life LM&P Announces Growth of Leadership Team 2Health News:Hormone Therapy Only Helps Some Older Men With Prostate Cancer 2Health News:Gastric Lap-Band Surgery Can Send Diabetes Into Remission 2Health News:Gastric Lap-Band Surgery Can Send Diabetes Into Remission 3Health News:STERIS Corporation Declares Regular Quarterly Dividend 2Health News:STERIS Corporation Declares Regular Quarterly Dividend 3
(Date:5/21/2015)... 21, 2015 Research ... the addition of the "North American ... Digit Replacement, Elbow Replacement, Hip Replacement, Knee ... report to their offering. ,     (Logo: ... was valued at $4,470.9 million in 2014 ...
(Date:5/21/2015)... DUBLIN , May 21, 2015 ... has announced the addition of the "North ... & Graft), by Application (Surgical Wound, & Ulcer), ... Forecast to 2019" report to their offering. ... wound care market is estimated to grow at ...
(Date:5/21/2015)... 2015 Research and ... addition of the "Arthroscopy Devices Markets ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,The purpose of this ... world market for Arthroscopy Devices. The report ... the market for these products. , ,Product ...
Breaking Medicine Technology:North American Joint Reconstruction Market 2015-2019 - Zimmer Holdings, DePuy Synthes Companies, Stryker, Biomet & Smith & Nephew Dominates the $4.4 Billion Market 2North American Active Wound Care Market 2015-2019 with Smith and Nephew, Molyncke HealthCare & ConvaTec Dominating 2Analysing Arthroscopy Devices Markets Worldwide 2014-2020 2Analysing Arthroscopy Devices Markets Worldwide 2014-2020 3
... , BOSTON, Nov. 23 AMICAS, Inc. ... management solutions, today announced that it will highlight its enterprise ... America (RSNA) annual meeting from November 29 to December 4 ... in booth #7124. , (Logo: http://www.newscom.com/cgi-bin/prnh/20060202/AMICASLOGO ) ...
... , MINNEAPOLIS, Nov. 23 BridgePoint Medical announced ... for its coronary and peripheral Chronic Total Occlusion (CTO) ... and the Stingray® CTO Re-Entry System. The BridgePoint ... designed to navigate highly diseased arteries in preparation for ...
Cached Medicine Technology:AMICAS' Enterprise Imaging Solutions Highlighted at RSNA 2009 2AMICAS' Enterprise Imaging Solutions Highlighted at RSNA 2009 3BridgePoint Medical(R) Receives European CE Mark for Stingray(R) and CrossBoss(TM) for Opening Completely Blocked Arteries 2BridgePoint Medical(R) Receives European CE Mark for Stingray(R) and CrossBoss(TM) for Opening Completely Blocked Arteries 3
... are becoming very popular only a few ... the pack. Explore why MediTalk is rapidly ... and practice administrators. An EMR designed by ... doctors see patients quickly and efficiently while ...
Transfer your exams to AltaPoint with our EMR Exam Word Lists. Document systems as normal and annotate exceptions to the systems in the exam. AltaPoint EMR is configured to allow a specialty to cust...
MediNotes e is an EMR design which utilizes a "tab concept for navigation. MediNotes e can display multiple patients, encounter notes, workflow items, patient flow, messages, alerts, and more, all in...
... Software developed a touchscreen EHR and is ... a user can choose to use a ... maintain eye contact while recording encounter results. ... EHR also runs on a pen tablet ...
Medicine Products: