Navigation Links
U of I study: exercise to avoid gallstones!
Date:2/13/2008

A new University of Illinois study shows that exercise-trained mice get far fewer gallstones than sedentary mice and identifies potential mechanisms to explain why this occurs.

The study, recently published in the Journal of Applied Physiology, can be viewed online at: http://jap.physiology.org/cgi/reprint/01292.2007v1.

For the first time, we have direct evidence that physical activity reduces gallstone formation, adding to the ever-increasing number of reasons that people should get more exercise,?said Kenneth Wilund, a faculty member in the U of I Division of Nutritional Sciences and an Assistant Professor in Kinesiology and Community Health.

Gallbladder disease affects 10 to 25 percent of adults in the United States, although some persons who are affected may not have symptoms. It has the second highest cost of any digestive disease at $5.8 billion annually and results in over 800,000 hospitalizations each year.

Gallstones form when bile cholesterol levels become high enough to precipitate, fall out of solution, and solidify, Wilund said.

In the study, 50 mice from a gallstone-susceptible strain were fed a high-fat diet containing cholic acid, which helps increase cholesterol absorption. They were then divided into two groups. One group of mice ran on treadmills 45 minutes per day five days a week; the other group did not exercise.

After 12 weeks, the scientists removed the animals?gallbladders, pooling the stones from each group and weighing them. The gallstones in the sedentary group weighed two and a half times more than the stones in the exercised group.

You could see through the gallbladders in the exercise-trained group, whereas the gallbladders in the sedentary group were full of stones,?Wilund said.

To understand more about why this happened, the scientists then measured the expression of selected genes in the liver and intestine that are involved in cholesterol absorption and may affect gallstone development.

In the exercised mice, we saw an increase in the expression of two genes (LDLr and SRB1) that help bring cholesterol into the liver to clear?it from the circulation. But we also found that a protein called Cyp27 was upregulated about two a half times; this resulted in there being more bile acids to solubilize the increased cholesterol so it didnt turn into gallstones.

Taken together, the differences in gene expression between the exercised and sedentary mice in this study show how exercise training could simultaneously improve cholesterol levels while also inhibiting gallstone formation,?he said.

Previous observational studies have suggested that people who are physically fit have fewer gallstones and lower cholesterol, but laboratory studies had not confirmed the link.

Wilund said these mice are a useful model because humans have a similar set of genes that regulate liver and bile cholesterol metabolism. He also said that human studies would be difficult to perform because of the number of years it takes for people to develop gallstones.

We certainly found the changes in gene expression in the exercised animals very intriguing,?he said. The results add to a body of evidence that supports the importance of physical activity for good health.?/p>

Co-authors of the study are Laura A. Feeney, Emily J. Tomayko, and Hae R. Chung of the University of Illinois and Kijin Kim of Keimyung University in Daegu, Korea. Funding was provided by the University of Illinois Research Board.


'/>"/>
Contact: Phyllis Picklesimer
p-pickle@uiuc.edu
217-244-2827
University of Illinois at Urbana-Champaign
Source:Eurekalert

Related medicine news :

1. Geisinger study: PTSD a medical warning sign for long-term health problems
2. Study: Brain connections strengthen during waking hours, weaken during sleep
3. New Study: Screening for Problem Drinking is One of the Most Cost-Effective Clinical Preventive Services
4. New study: US ranks last among other industrialized nations on preventable deaths
5. Study: Short sleep times in patients with chronic medical diagnoses linked to obesity
6. New Lancet Study: Tobacco Control Measures Are Effective and Affordable Strategies to Reduce Chronic Disease Deaths Globally
7. WHO Study: Night Shift Work May Cause Cancer
8. NCPA Study: Government, Insurers Keep Medicine in Stone Age
9. New Study: Health Insurance Mandates on Employers Hurt Low-Income Employees
10. COURAGE Sub-study: PCI Outperforms Drugs-Only
11. U of M study: Medicare lacks tools, incentives to enforce evidence-based coverage policies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... Cambridge, MA (PRWEB) , ... December 08, 2016 , ... ... decreases in medical payments per workers’ compensation claim in 2013 and 2014, according to ... Workers Compensation Research Institute (WCRI) . , According to the study, medical payments per ...
(Date:12/8/2016)... ... December 08, 2016 , ... The Dianne Michael Insurance Agency, ... Hamilton County, is embarking on a charity drive with the aim of generating ... for orphaned or neglected senior dogs in the Cincinnati region, and LuvFurMutts volunteers ...
(Date:12/8/2016)... ... December 08, 2016 , ... Coffey Agencies, a locally owned ... clients in the northern Alabama and Georgia regions, is embarking on a charity ... Works has built a network of support and education facilities to develop and ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... Kenall Manufacturing, ... new MedMaster™ MPCNGX . The MPCNGX is a multi-function, sealed, LED luminaire that ... amount of light where and when it’s needed. , A 2’ x ...
(Date:12/7/2016)... Atlanta, Georgia (PRWEB) , ... ... ... announced today it has acquired Presence Technology, S.L. (“Presence”) for a purchase ... certain price adjustments and other considerations. Presence’s annual revenue is approximately $13.2 ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... Dec. 8, 2016  Valeant Pharmaceuticals International, Inc. ... ("Valeant") today announced positive results from a Phase ... assess the safety and efficacy of IDP-118 (halobetasol ... plaque psoriasis. Within the Phase ... to severe psoriasis, IDP-118 showed statistical significance to ...
(Date:12/8/2016)... Mederi Therapeutics Inc . hat die behördliche Zulassung durch die CFDA sowie ... – in China angekündigt. ... ... Live Stretta procedure performed and broadcast during the Chinese Congress ... Union Hospital ...
(Date:12/8/2016)... , Dec. 8, 2016  Boehringer Ingelheim announced today ... Equality Index (CEI). This is the ninth time that ... designated as a Best Place to Work for LGBT ... CEI is a national benchmarking report on corporate policies ... bisexual and transgender (LGBT) employees. "We ...
Breaking Medicine Technology: