Navigation Links
U of I scientist says slimming soybeans are on the horizon
Date:4/1/2010

URBANA If you're serious about losing weight, check out recent studies done in Elvira de Mejia's University of Illinois laboratory. Her research provides insight into the way a certain type of soy protein inhibits fat accumulation and reduces inflammation.

"We found that soybeans rich in beta-conglycinins limit lipid accumulation in fat cells by inhibiting an enzyme called fatty acid synthase. What's more, we have identified the specific peptides (digested proteins) that do this, and we are now beginning to understand the mechanism behind it. This is exciting research because it could lead to the development of nutraceuticals to fight obesity," said de Mejia, a U of I associate professor of food science and human nutrition.

The study was also the first to establish the anti-inflammatory properties of soy high in this type of protein. "The peptides fight inflammation by blocking key enzymes in the body's immune response," said the scientist.

de Mejia said that soy contains, among others, two types of protein, glycinins and beta-conglycinins, and the most important factor influencing a soy cultivar's healthful effects is the proportion in which they occur. Her research shows that soy that is low in glycinins and high in beta-conglycinins is preferred for its ability to inhibit lipid accumulation and inflammation.

"Using the latest molecular marker-assisted breeding techniques, soybeans with the right composition can be tagged and later identified using a simple leaf tissue sample. This would make it possible to create high-yielding cultivars that contained the 'slimming' trait for soybean farmers to grow in their fields," she said.

How did de Mejia discover that certain soybeans had this slimming effect? She had learned from her previous research that administration of soy protein caused weight loss in laboratory rats, but she wanted to know exactly why it happened.

She incubated human fat cells in the lab, treated them with soy hydrolysates from 15 soy genotypes containing varying amounts of beta-conglycinin, and then measured the amount of fat that accumulated.

"As we increased the concentration of beta-conglycinin, we saw more inhibition of lipids and less accumulation of fat. Further testing showed that this occurred because fatty acid synthase, an enzyme responsible for synthesizing lipids, had been suppressed.

"We also found that fat cells exposed to digests made from the 'slimming' soybeans increased the synthesis of adiponectin, a hormone that enhances insulin sensitivity and fat metabolism," she said.

She then compared the activity of beta-conglycinins with glycinins and found that hydrolysates from beta-conglycinins inhibited almost 50 percent of lipid accumulation in the fat cells. Glycinins did not inhibit lipid accumulation at all, she said.

In a separate study, her team identified specific soy peptides that inhibit fatty acid synthase, and they were able to learn exactly how it happens.

de Mejia and her colleagues are now taking their research a step further by performing human trials with soy milk that is high in beta-conglycinins.

"For years we've known that soy protein is a good source of essential amino acids. Soy helps us maintain muscle mass, and its peptides make people feel full so they don't eat as much," she said.

"Now it appears that products made from soybeans selected for this particular protein profile may also help limit fat accumulation. Food manufacturers will be able to create soy products targeted at consumers who are trying to maintain their ideal weight," she said.


'/>"/>

Contact: Phyllis Picklesimer
p-pickle@illinois.edu
217-244-2827
University of Illinois at Urbana-Champaign
Source:Eurekalert

Related medicine news :

1. Scientists ID a protein that splices and dices genes
2. Breakthrough by Danish scientists in preventing maternal malaria
3. NIH scientists identify maternal and fetal genes that increase preterm birth risk
4. UM School of Medicine scientists find new malaria vaccine is safe and protective in children
5. Gladstone scientists identify target that may reduce complications of obesity
6. Scientists map out regulatory regions of genome, hot spots for diabetes genes
7. Doctors and Scientists Create New Society to Promote Non-Animal Toxicology Testing Methods
8. Scientists discover enzyme that cleans cancer cells
9. Scientists Decode Brain Cancer Cell Line
10. Scientists show how molecular switch helps pancreatic cancer beat drugs
11. Brain scientists extend map of fear memory formation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ... , "Film editors can give their videos a whole new perspective by using the ... CEO of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets ...
(Date:6/25/2016)... ... ... Austin residents seeking Mohs surgery services, can now turn to Dr. Jessica ... Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include Mohs ... Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn Goldstein, ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... recover from injury. Recently, he has implemented orthobiologic procedures as a method for ... is one of the first doctors to perform the treatment. Orthobiologics are substances ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World ... with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the ...
(Date:6/24/2016)... Diego, CA (PRWEB) , ... June 24, 2016 , ... ... with the American Cancer Society and the Road To Recovery® program to drive cancer ... to seniors and other adults to ensure the highest quality of life and ongoing ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CHAPEL HILL, N.C. , June 24, 2016 ... in healthcare decisions and regulators/payers have placed more ... this new environment, patient support programs in the ... support for patients, medications. Consequently, pharmaceutical companies are ... to ensure they are providing products and services ...
(Date:6/24/2016)... CAMBRIDGE, Mass. , June 24, 2016 /PRNewswire/ ... the Spaulding Rehabilitation Network,s Dean Center for ... of Physical Medicine and Rehabilitation, MIT Hacking Medicine, ... Center for Innovation, today announced the five finalists ... Hackathon for Lyme disease.  More than 100 scientists, ...
(Date:6/24/2016)... 2016 The Academy of Managed Care Pharmacy ... that would allow biopharmaceutical companies to more easily share ... formulary and coverage decisions, a move that addresses the ... The recommendations address restrictions in the sharing ... drug label, a prohibition that hinders decision makers from ...
Breaking Medicine Technology: