Navigation Links
U of Alberta researchers hoping to stop heart disease in cancer patients before it starts

Researchers in the Faculty of Medicine & Dentistry are trying to reverse a devastating trend: cancer survivors developing cardiovascular disease, one of the top two killers in Canada.

Ian Paterson, an assistant professor of cardiology at the University of Alberta and Edie Pituskin, a registered nurse and PhD candidate in the Faculty of Rehabilitation Medicine, are starting what is called the MANTICORE clinical trials. Women with breast cancer will be put on heart medication before their cancer treatment.

"Our goal is to look at patients diagnosed with cancer and to detect heart disease and risk factors for heart disease sooner then they're being recognized and treat them aggressively," said Paterson. "We're hoping we can prevent heart disease not only during cancer treatment itself but after the cancer treatment is done."

All patients enrolled in this study must start on the heart disease medication with Paterson and Pituskin prior to treatment.

Paterson and Pituskin decided to start with breast cancer patients because it is the leading cancer in women and the leading cause of cancer deaths in women. Treatments have improved drastically over the years, in particular one pharmaceutical called Herceptin.

"The drug has been shown to really improve survival rates of some types of breast cancer," said Paterson. "Unfortunately it can also damage the heart in up to 20 per cent of women taking this drug.

"We're trying to detect signs of injury much more quickly using special blood tests and special imaging tests like an eco-cardiogram and MRI."

The pair will also try to detect if any of the women involved in the study have cardiac risk factors like high blood pressure and they'll try to treat those very aggressively.

MANTICORE looks to enrol 139 patients, so far 15 are involved in Edmonton and the study is now adding centres in Winnipeg and Toronto. The study is being funded by the Alberta Cancer Foundation and Canadian Institutes of Health Research.

Cardio-oncology is an emerging field of medicine and Paterson and Pituskin are leading the way.

"We're one of the first and we could serve as a blue print for other programs," said Paterson, who also added they want to get a number of sites nationally on board with the trials. "Then we'll be able to track outcomes for these patients and develop a registry where we can track how people are doing and have these clinics make a difference."


Contact: Quinn Phillips
University of Alberta Faculty of Medicine & Dentistry

Related medicine news :

1. Most common cancers in the world decreasing in Alberta: Study
2. Gender-bending fish on the rise in southern Alberta
3. Warning labels better than a fat tax, University of Alberta study shows
4. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
5. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
6. Researchers discover new way to kill pediatric brain tumors
7. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
8. Researchers create drug to keep tumor growth switched off
9. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
10. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
11. Clemson researchers develop hands-free texting application
Post Your Comments:
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs ... College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. ... treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand ... project," said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s ... within Final Cut Pro X . Simply select a ProHand generator and drag ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... As a ... Magna Cum Laude and his M.D from the David Geffen School of Medicine at ... returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars ...
(Date:6/25/2016)... ... 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the ... to iHire in recognition of their exemplary accomplishments in worksite health promotion. , The ... Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article ... are unfamiliar with. The article goes on to state that individuals are now more ... these less common operations such as calf and cheek reduction. The Los Angeles area ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... VEGAS , June 26, 2016 ... to value-based care operating models within the health care ... enable greater financial efficiency , Deloitte offers a ... the key business issues impacting efficient cost optimization: labor ... , These services facilitate better outcomes and better ...
(Date:6/24/2016)... , June 24, 2016 ... Markets has announced the addition of the " ... offering. This ... and provides an updated review, including its applications in ... the total market, which includes three main industries: pharmaceutical ...
(Date:6/24/2016)... Research and Markets has announced the addition of ... report to their offering. ... The World Market for Companion Diagnostics covers the world market ... the report includes the following: , World ... Region (N. America, EU, ROW), 2015-2020 , World IVD ...
Breaking Medicine Technology: