Navigation Links
U of A researchers hope to stop heart

Researchers in the Faculty of Medicine & Dentistry are trying to reverse a devastating trend: cancer survivors developing cardiovascular disease, one of the top two killers in Canada.

Ian Paterson, an assistant professor of cardiology at the University of Alberta and Edie Pituskin, a registered nurse and PhD candidate in the Faculty of Rehabilitation Medicine, are starting what is called the MANTICORE clinical trials. Women with breast cancer will be put on heart medication before their cancer treatment.

"Our goal is to look at patients diagnosed with cancer and to detect heart disease and risk factors for heart disease sooner then they're being recognized and treat them aggressively," said Paterson. "We're hoping we can prevent heart disease not only during cancer treatment itself but after the cancer treatment is done."

All patients enrolled in this study must start on the heart disease medication with Paterson and Pituskin prior to treatment.

Paterson and Pituskin decided to start with breast cancer patients because it is the leading cancer in women and the leading cause of cancer deaths in women. Treatments have improved drastically over the years, in particular one pharmaceutical called Herceptin.

"The drug has been shown to really improve survival rates of some types of breast cancer," said Paterson. "Unfortunately it can also damage the heart in up to 20 per cent of women taking this drug.

"We're trying to detect signs of injury much more quickly using special blood tests and special imaging tests like an eco-cardiogram and MRI."

The pair will also try to detect if any of the women involved in the study have cardiac risk factors like high blood pressure and they'll try to treat those very aggressively.

MANTICORE looks to enrol 139 patients, so far 15 are involved in Edmonton and the study is now adding centres in Winnipeg and Toronto. The study is being funded by the Alberta Cancer Foundation and Canadian Institutes of Health Research.

Cardio-oncology is an emerging field of medicine and Paterson and Pituskin are leading the way.

"We're one of the first and we could serve as a blue print for other programs," said Paterson, who also added they want to get a number of sites nationally on board with the trials. "Then we'll be able to track outcomes for these patients and develop a registry where we can track how people are doing and have these clinics make a difference."


Contact: Quinn Phillips
University of Alberta Faculty of Medicine & Dentistry

Related medicine news :

1. UofL researchers uncover mechanism in saliva production
2. UF researchers suggest cholera vaccination strategies for Zimbabwe
3. Researchers characterize epigenetic fingerprint of 1,628 people
4. Researchers develop strategy to improve patient adherence
5. NIH-funded researchers find new ways to confuse blood-seeking mosquitoes
6. GW researchers show host Mta1 gene is required for optimal survival of schistosome parasites, a leading global cause of cancer
7. Researchers map, measure brains neural connections
8. Carnegie Mellon researchers uncover how the brain processes faces
9. UCI researchers find link between environment and genetics in triggering MS
10. Drug can reverse overgrown hearts to help prevent heart failure, UT Southwestern researchers find
11. UBC researchers to lead $4.7-million study on early-stage oral cancer
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... According to an article ... the way that they are handling security in light of the recent terrorist attacks ... in an attempt to stop an attack from reaching U.S. soil. Especially around special ...
(Date:11/27/2015)... ... November 27, 2015 , ... Lizzie’s Lice Pickers just ... is offering customers 10% off of their purchase of lice treatment product. In addition, ... price. According to a company spokesperson. “Finding lice is a sure way to ruin ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... well-respected Microsoft Dynamics SL User Group (MSDSLUG). Recognized as Microsoft’s official group for ... of Microsoft Dynamics SL software users, partners, industry experts and representatives. Intellitec Solutions’ ...
(Date:11/27/2015)... ... November 27, 2015 , ... The men and ... nonprofit healthcare organizations in the country. They have overseen financial turnarounds, shown commitment ... advance the healthcare industry as a whole through their advocacy and professional efforts. ...
(Date:11/26/2015)... ... November 26, 2015 , ... Inevitably when people think ... customers choose to buy during the Black Friday and Cyber Monday massage chair ... to search the Internet high and low to find the best massage chair deals, ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... North Carolina , 26 november 2015 ... Inc. (AAIPharma/CML) kondigt de geplande investering aan ... uitbreiding van de laboratoria en het mondiale ... . De uitbreiding zal resulteren in extra ... wordt voldaan aan de groeiende behoeften van ...
(Date:11/26/2015)... and Markets ( ) has announced the addition of ... - Rise in Cardiac Disorders and Growing Awareness among People ... Boston scientific and others. ... others. --> The market is dominated by ... scientific and others. Asia ...
(Date:11/26/2015)... 2015 ... the  "2016 Future Horizons and Growth ... Testing Market: Supplier Shares, Competitive Intelligence, ... --> ) has ... Future Horizons and Growth Strategies in ...
Breaking Medicine Technology: