Navigation Links
U.S. Oncology Initiates Complete Phase Ib Trial of Brostallicin Combination Therapy in Advanced Solid Tumors
Date:10/18/2007

F.A.C.P., Physician-in-Chief and Director of the Clinical Translational Research Division at the Translational Genomics Research Institute (TGen), Chief Scientific Officer of U.S. Oncology. "With its extensive patient screening at multiple sites, U.S. Oncology is uniquely suited to conduct such studies with a single protocol and parallel multiple regimens."

"Extensive preclinical studies demonstrated that brostallicin is synergistic with multiple agents including both bevacizumab and irinotecan," said James A. Bianco, President and CEO of CTI. "This trial is designed to rapidly follow-up that preclinical data in one consolidated phase I study, save time and expense normally associated with the start up of multiple trials, accrue eligible patients rapidly and generate data to better inform the design of future randomized phase II or III trials."

About Brostallicin

Brostallicin, a novel synthetic second-generation DNA minor groove binder, has potent cancer killing activity and has demonstrated synergism in combination with standard cytotoxic agents as well as with newer targeted therapies in preclinical experimental tumors models. Brostallicin binds covalently to DNA within the DNA minor groove interfering with DNA division and leading to tumor cell death. More than 200 patients have been treated with brostallicin in single-agent and combination studies. Brostallicin had predictable and predominantly hematologic toxicities. Activity was demonstrated in a number of solid tumor types. A phase II study of brostallicin in relapsed/refractory soft tissue sarcoma met its pre-defined activity and safety hurdles and resulted in a first-line phase II study that is currently being conducted by the European Organization for Research and Treatment of Cancer (EORTC).

Brostallicin was discovered at Pharmacia and developed by Nerviano Medical Sciences (NMS) the largest pharmaceutical research and development facility in Italy and one of the largest oncology-
'/>"/>

SOURCE Cell Therapeutics, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Radiation Overdose at the Beatson Oncology Centre
2. Videoconferencing, an impetus to Pediatric Oncology
3. Oncology Drug Pemnat Launched By NATCO
4. United Biotech Launches New Oncology Division
5. Bengal Teenager to Participate in World Oncology Camp
6. CMPMedica Adds Oncology Search Engine to SearchMedica.com
7. Bird Flu: Orissa Initiates Protective Measures
8. Biota Initiates Drug Testing War against Common Cold
9. Russia Initiates Mass Vaccination Of Poultry To Restrict Bird Flu
10. Government Initiates A Program To Curb HIV
11. Alteon Initiates Phase 2 Trial of ALT-2074 in Diabetes and Haptoglobin 2-2
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... (PRWEB) April 27, 2015 Telematics Berlin ... tier 1&2 suppliers, associations, CE players and the government ... has opened to the car. This year’s panel on ... DG-Move at the European Commission, is an opportunity to ... and define a European Automotive Security Standard for years ...
(Date:4/27/2015)... 27, 2015 Attorney Dan Newlin, of the ... and protecting his clients, took that commitment to a whole ... code which makes it easier for existing and potential clients ... building his brand and added value to the firm’s services, ... area where Newlin has law offices. , “I knew the ...
(Date:4/27/2015)... Scooter Direct is now offering Pride ... price of only $929.00, marked down from the MSRP ... is known for offering quality mobility solutions to its ... wheel chairs, lift chairs, and their accessories at unbeatable ... of Go Go Traveller Elite, a senior store manager ...
(Date:4/27/2015)... On the top floor of the luxurious Beverly ... Los Angeles, CA, Per Wickstrom had an in-depth conversation ... of Orange County” Gretchen Christine Rossi. , In ... “Salute to the Oscars” celebration, sponsored by Choices Recovery, ... Wickstrom, Rossi felt that the evening’s interviews would not ...
(Date:4/27/2015)... Denver, Colorado (PRWEB) April 27, 2015 ... a ground-breaking solution to a problem that has ... marketing and advertising campaigns: by announcing the ... engine of its kind. , Officially launched ... industry and was created to index only marijuana-related ...
Breaking Medicine News(10 mins):Health News:Telematics Berlin: European Commission discuss a pan European Automotive Security Strategy 2Health News:Telematics Berlin: European Commission discuss a pan European Automotive Security Strategy 3Health News:Dan Newlin Hashtags It With #Dan 2Health News:Scooter Direct Offering Pride Go Go Traveller Elite 3-Wheel Scooter At Discounted Price 2Health News:Scooter Direct Offering Pride Go Go Traveller Elite 3-Wheel Scooter At Discounted Price 3Health News:Per Wickstrom Shares His Vision of Choices Recovery with Reality TV Star Gretchen Christine Rossi 2Health News:The WeedLife Network debuts its ground-breaking WeedLIVE cannabis industry search engine 2Health News:The WeedLife Network debuts its ground-breaking WeedLIVE cannabis industry search engine 3
... risk factor for active tuberculosis (TB) disease, according to a ... research analyzed data from nearly 17,000 individuals in Taiwan as ... While past studies have reported increased mortality among TB patients ... direct effect of smoking on active TB incidence using a ...
... ... professionals , ... August 23, 2009 -- An aging population and medical advances are a couple of ... (NRAF) is honoring the difference they make during the 2009 National Rehabilitation Awareness ...
... and methods, experts say simple CPR works best , SUNDAY, ... to participating in a flurry of activity when trying to ... IVs, placing a breathing tube, performing defibrillation to restart the ... advanced techniques saves lives as well as ordinary cardiopulmonary resuscitation, ...
... , LOUISVILLE, Ky., Aug. 22 A top medical ... Legion and colleague veterans service organizations can play a key role ... national suicide prevention coordinator, in pointing to the 5,000 self-inflicted deaths ... of our responsibility to own up to that. There,s no reason ...
... YouTube ... , ... August 22, 2009 -- Over 50 million American men suffer from hair loss. With that ... male pattern hair loss sufferer, Kevin Nalty (a.k.a. "Nalts") to raise awareness about hair loss ...
... Aug. 7, 2009 Dr. Glen Weiss of ... this week announced two significant advances in treating lung ... Weiss, M.D., an Associate Investigator in TGen,s Cancer and ... TGen Clinical Research Services at Scottsdale Healthcare, made both ...
Cached Medicine News:Health News:Smoking increases risk of developing active TB 2Health News:Smoking increases risk of developing active TB 3Health News:Medical Advances, Population Changes Fuel Demand for Rehabilitation Professionals 2Health News:It's Back to Basics to Save a Life 2Health News:It's Back to Basics to Save a Life 3Health News:The American Legion Can Play Key Role in Vets' Suicide Prevention, Says VA 2Health News:Vlogging For Hair: YouTube Star 'Nalts' Promotes Hair Loss Awareness with Dr. Alan Bauman 2Health News:Vlogging For Hair: YouTube Star 'Nalts' Promotes Hair Loss Awareness with Dr. Alan Bauman 3Health News:Vlogging For Hair: YouTube Star 'Nalts' Promotes Hair Loss Awareness with Dr. Alan Bauman 4Health News:Advances in lung cancer research announced at conference 2
(Date:4/27/2015)... 27, 2015 BioLife Solutions , Inc. ... marketer of proprietary clinical grade hypothermic storage ... thermal shipping products for cells and tissues ("BioLife" ... Food and Drug Administration has confirmed acceptance of the ... While not an endorsement nor approval of BioLife,s products ...
(Date:4/26/2015)... 2015 Cancer experts have reported how a ... in the area of distributed learning is helping to ... of patients. Speakers at a Varian-hosted symposium at the ... in Barcelona detailed the importance ... knowledge to help benefit the next patient. ...
(Date:4/24/2015)... , und BARCELONA ... (Stand Nr. 4410) iCAD, Inc. (Nasdaq: ... moderner Bildanalyse, Lösungen für Behandlungsabläufe und Strahlentherapie ... hat heute die sofortige Verfügbarkeit des ersten ... Brachytherapy (eBx ® ) System ® ...
Breaking Medicine Technology:BioLife Solutions Submits FDA Master Files for Cell Thawing Media Products 2BioLife Solutions Submits FDA Master Files for Cell Thawing Media Products 3BioLife Solutions Submits FDA Master Files for Cell Thawing Media Products 4Cancer Experts Detail How 'Big Data' Plays a Critical Role in Improving Clinical Decision-Making in Oncology Treatments at 3rd ESTRO Forum 2Cancer Experts Detail How 'Big Data' Plays a Critical Role in Improving Clinical Decision-Making in Oncology Treatments at 3rd ESTRO Forum 3Erste Klinik in Spanien setzt das Xoft Electronic Brachytherapy System für die Behandlung von Brustkrebs im Frühstadium, nicht-melanozytärem Hautkrebs und gynäkologischen Krebserkrankungen ein 2Erste Klinik in Spanien setzt das Xoft Electronic Brachytherapy System für die Behandlung von Brustkrebs im Frühstadium, nicht-melanozytärem Hautkrebs und gynäkologischen Krebserkrankungen ein 3Erste Klinik in Spanien setzt das Xoft Electronic Brachytherapy System für die Behandlung von Brustkrebs im Frühstadium, nicht-melanozytärem Hautkrebs und gynäkologischen Krebserkrankungen ein 4Erste Klinik in Spanien setzt das Xoft Electronic Brachytherapy System für die Behandlung von Brustkrebs im Frühstadium, nicht-melanozytärem Hautkrebs und gynäkologischen Krebserkrankungen ein 5Erste Klinik in Spanien setzt das Xoft Electronic Brachytherapy System für die Behandlung von Brustkrebs im Frühstadium, nicht-melanozytärem Hautkrebs und gynäkologischen Krebserkrankungen ein 6
... May 22, 2012 Cephasonics, Inc., a ... and subsystems to the imaging and ultrasound markets, ... agreement with Tritech Ltd.  Tritech, a leading Israeli ... partner driving the success of Cephasonics, embedded-ultrasound product ...
... NEWTON, Mass., May 22, 2012  Halo Therapeutics, LLC, ... rare fibrotic diseases, announced today that it has ... foundations serving the muscular dystrophy patient community. Halo ... 2 study of HT-100, its lead drug candidate ...
Cached Medicine Technology:Cephasonics Inks Distribution Deal With Tritech To Extend Worldwide Sales Reach Into Israel 2Halo Therapeutics Raises $1.1 Million to Expedite Phase 2 Study of HT-100 2Halo Therapeutics Raises $1.1 Million to Expedite Phase 2 Study of HT-100 3
Midstream Catch Kits...
... The BladderScan® is a portable, noninvasive ... is battery-operated, easy to use, and quickly ... minutes, you can use the BladderScan® to ... bladder volume. The BladderScan® supplies the information ...
... The Pediatric BladderScan® is ... Diagnostic Ultrasound's trusted family ... enabling healthcare providers to ... volume noninvasively, this easy-to-use, ...
... BVI 6300 Bladder Monitor is a ... the healthcare provider to enable patients ... ongoing basis. It is easy to ... so the patient can make informed ...
Medicine Products: