Navigation Links
U.S. Health Officials Back Off Preference for New MMRV Vaccine

CDC reports more seizures seen in toddlers given combined shot; experts stress real risk is still low

THURSDAY, March 13 (HealthDay News) -- U.S. health officials are no longer recommending the combination MMRV (measles, mumps, rubella and varicella) vaccine over the MMR vaccine and a separate varicella vaccine for kids.

The change comes after new data show that the MMRV shot increases the risk for febrile seizure in children aged 12 to 23 months. Preliminary findings suggest there is a doubling in the relative increased risk in this age group within a week to 10 days after receiving the shot, according to a report in the March 14 issue of the Morbidity and Mortality Weekly Report, published by the U.S. Centers for Disease Control and Prevention.

Based on the preliminary data, the CDC'S Advisory Committee on Immunization Practices (ACIP) is withdrawing its preference, issued last year, for the combination vaccine over the two separate injections.

But the absolute risk of febrile seizures is still low, experts stressed.

"The relative risk doesn't really give parents the true understanding of what's happening," said Dr. Robert Frenck, a professor of pediatrics at Cincinnati Children's Hospital. "A big pediatric practice maybe has 100 newborns a month added to its practice, so that they may see one [incidence of febrile seizure related to the vaccination] a year."

And because of manufacturing difficulties, the MMRV shot, made by Merck, won't really be available until about this time next year, added Frenck, who is a member of the American Academy of Pediatrics' committee on infectious diseases.

The MMRV was licensed by the U.S. Food and Drug Administration on Sept. 6, 2005, for use in children aged 12 months to 12 years. The first dose was recommended at 12 to 15 months, and the second at 4 to 6 years.

But the Vaccine Safety Datalink (VSD), which monitors vaccine safety, detected a signal for increased seizures in children aged 12 to 23 months who got the MMRV shot compared with those who got the MMR one (many children also got varicella). The MMR shot is also known to cause febrile seizures, Frenck said.

The VSD then initiated a study of 43,353 children aged 12 to 23 months who received the MMRV vaccine and 314,599 children aged 12 to 23 months who received the MMR vaccine and varicella vaccine during the same visit, according to the CDC report.

"The preliminary results indicated a rate of febrile seizure of nine per 10,000 vaccinations among MMRV vaccine recipients compared with four per 10,000 vaccinations among MMR vaccine and varicella vaccine recipients," the CDC reported. "These results suggest that, in the 7-10 day post-vaccination period, approximately one additional febrile seizure would occur among every 2,000 children vaccinated with MMRV vaccine, compared with children vaccinated with MMR vaccine and varicella vaccine administered at the same visit."

On Feb. 27, the ACIP was informed about the heightened risk.

Febrile seizures are convulsions brought on by fever, usually from common childhood illnesses such as middle ear infections, viral upper respiratory tract infections and roseola. Although the seizures are distressing, children generally recover, according to the CDC.

"Practically speaking, it means little," said Dr. Paul A. Offit, director of the Vaccine Education Center and chief of infectious diseases at the Children's Hospital of Philadelphia. "The attributable risk of fever is still quite low. I think the committee thought the better part of valor was at least not to express a preference for one over the other. For the most part, MMRV is not particularly available, so there's little or no impact."

There is no data yet on the risk for febrile seizures after the second MMRV vaccine, which is given at 4 to 6 years of age, although previous research showed that the second dose is less likely to cause fever than the first.

The changes have nothing to do with a possible vaccination link to autism, Frenck said.

More information

The Vaccine Safety Datalink has more on vaccine and febrile seizures.

SOURCES: Robert Frenck, M.D., professor, pediatrics, Cincinnati Children's Hospital, and member, American Academy of Pediatrics committee on infectious diseases; Paul A. Offit, M.D., director, Vaccine Education Center, and chief, infectious diseases, Children's Hospital of Philadelphia; March 14, 2008, Morbidity and Mortality Weekly Report, U.S. Centers for Disease Control and Prevention

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Air pollution linked to cardiovascular risk indices in healthy young adults
4. More proof needed of safety and quality of electronic personal health records
5. Health care incentive model offers collaborative approach
6. Loneliness is bad for your health
7. Mailman School of Public Health study examines link between racial discrimination and substance use
8. Green Tea May Brew Up Healthier Skin
9. For Health Info, Women Often Turn to the Web
10. Record Number of Americans Lack Health Insurance
11. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
Post Your Comments:
Related Image:
U.S. Health Officials Back Off Preference for New MMRV Vaccine
(Date:11/29/2015)... ... November 29, 2015 , ... Key Housing, a top-rated corporate housing service ... 2015, featured apartment community: Epic. In showcasing this featured apartment community in San Jose, ... Area rental market to efficiently find housing suitable to their needs by showcasing quality ...
(Date:11/28/2015)... ... 28, 2015 , ... Beginning November 30th at 6:00 a.m. EST until 11:59 p.m. EST, ... possible savings of up to 20% off orders $80 or more to free gifts with ... few hours. , As a competitive e-commerce website for skin care and cosmetic needs, customers ...
(Date:11/27/2015)... CA (PRWEB) , ... November 27, 2015 , ... According ... carried out by the University of Toronto and the University of British Columbia suggested ... hospitalizations for head injuries. The article explains that part of the reason for the ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... and convenient way to dispense prescription medications at home, so he invented the ... to monitor and dispense prescription medications. In doing so, it could help to ...
(Date:11/27/2015)... ... 27, 2015 , ... ProSidebar: Fashion is a set of 30 ... ProSidebar: Fasion, video editors can easily add an informative sidebar to any FCPX production. ... Utilize presets featuring self-animating drop zones, lines, bars, and text with the ease of ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , Países Bajos, November 26, 2015 ... la terapia fotodinámica de Bremachlorin para el cáncer avanzado. ... la inmunoterapia con la terapia fotodinámica de Bremachlorin para ... Un nuevo enfoque combina la inmunoterapia con la terapia ... Clinical Cancer Research . --> ...
(Date:11/26/2015)... -- --> --> Juntendo ... optimal contrast weighting of MRI for patients with Multiple ... research agreement with SyntheticMR in order to use SyMRI in ... possible to generate multiple contrast images from a single scan ... thus making it possible to both fine tune images and ...
(Date:11/26/2015)... ) has ... Future Horizons and Growth Strategies in the ... Shares, Country Segment Forecasts, Competitive Intelligence, Emerging ... --> ) has announced the ... and Growth Strategies in the French Drugs ...
Breaking Medicine Technology: