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U.S. Department of Defense Exercises $2.0 Million Option to Fund Cethromycin Development
Date:3/19/2009

- Company Presents Data on Cethromycin Showing In Vivo Efficacy against Tularemia -

CHICAGO, March 19 /PRNewswire-FirstCall/ -- Advanced Life Sciences Holdings, Inc. (Nasdaq: ADLS), a biopharmaceutical company developing cethromycin, a novel once-a-day antibiotic, to treat respiratory tract infections and to combat bioterror threats, announced today that it received notice from the Department of Defense (DoD) that it has exercised its option to award the Company $2.0 million under the previously announced contract to develop cethromycin as a broad-spectrum medical countermeasure.

(Logo: http://www.newscom.com/cgi-bin/prnh/20080218/ALSLOGO)

The contract is funding NDA-enabling studies to evaluate cethromycin's efficacy in combating Category A and B bioterror agents such as Fransicella tularensis (tularemia), Yersinia pestis (plague) and Burkholderia pseudomallei (melioidosis). Under the terms of the contract, $1.8 million of DoD funds were initially available to initiate the studies. The $2.0 million optional award announced today represents the remaining balance of the $3.8 million contract.

"DoD's decision to exercise its option to the full amount of the contract represents a strong vote of confidence in the potential of cethromycin as a biodefense therapy, and it enables us to complete pivotal studies to expand cethromycin's potential spectrum of activity in biodefense beyond the success that was demonstrated in preventing inhalation anthrax," stated Dr. Michael T. Flavin, chairman and chief executive officer of Advanced Life Sciences. "Since contract inception, we have strengthened our relationship with DoD and believe that cethromycin can ultimately meet the DoD's goal of protecting
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SOURCE Advanced Life Sciences Holdings, Inc.
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