Navigation Links
U-M study uncovers key to how 'triggering event' in cancer occurs
Date:10/29/2009

ANN ARBOR, Mich. Researchers at the University of Michigan Comprehensive Cancer Center have discovered what leads to two genes fusing together, a phenomenon that has been shown to cause prostate cancer to develop.

The study found that pieces of chromosome relocate near each other after exposure to the hormone androgen. This sets the scene for the gene fusion to occur. The finding is reported online Oct. 29 in Science Express.

"This work shows the origin of how the gene fusion is actually created and perhaps the origin of prostate cancer itself. This is a triggering event for the genesis of prostate cancer," says study author Arul Chinnaiyan, M.D., Ph.D., director of the Michigan Center for Translational Pathology and S.P. Hicks Professor of Pathology at the U-M Medical School. Chinnaiyan is also a Howard Hughes Medical Institute investigator.

Chinnaiyan and his team identified in 2005 a prostate-specific gene called TMPRSS2 that fuses with the gene ERG, which is known to play a role in prostate cancer. Their earlier research has shown that this gene fusion acts as an "on switch" to trigger prostate cancer. In the current study, the researchers focused on what causes the gene fusion to occur.

The researchers took prostate cancer cells that did not reflect the gene fusion but that were sensitive to androgen, a male hormone known to play a role in some prostate cancers. They exposed the cells to androgen and found that two pieces of chromosome that are normally far apart are relocated near each other.

Next, the researchers applied radiation to the androgen-stimulated cells. This stress or insult to the cells designed to induce chromosomal breaks led to the gene fusion occurring.

"We thought the gene fusions occurred as a chance event, but it's not. Chromosomes can actually be induced in three-dimensional space to be close to each other. Then when an insult to the DNA occurs, the fusion happens," says lead study author Ram-Shankar Mani, Ph.D., a research fellow in pathology at the U-M Medical School.

The researchers believe the findings could have implications for gene fusions that occur in other cancer types. By understanding how gene fusions occur, the researchers suggest that screening tools or prevention strategies could potentially be developed.


'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
U-M study uncovers key to how 'triggering event' in cancer occurs
(Date:6/26/2016)... ... 2016 , ... On June 10-11, 2016, A Forever Recovery, a holistic treatment ... Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. This ... of the world’s leading providers of cereal and other breakfast foods. Its residents often ...
(Date:6/26/2016)... , ... June 26, 2016 , ... ... once they have been diagnosed with endometriosis. These women need a treatment plan ... require a comprehensive approach that can help for preservation of fertility and ultimately ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX ... Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over ... Cut Pro X . Simply select a ProHand generator and drag it above media ...
(Date:6/25/2016)... ... ... Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and Mental ... exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took place ... BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive an ...
(Date:6/24/2016)... ... 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. ... the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has ... , Sickle Cell Disease (SCD) is a disorder of the red blood cells, which ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
(Date:6/23/2016)... , June 23, 2016 Any dentist who has ... of the current process. Many of them do not even ... technical difficulties and high laboratory costs involved. And those who ... it at such a high cost that the majority of ... Dr. Parsa Zadeh , founder of Dental Evolutions ...
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
Breaking Medicine Technology: