Navigation Links
U-M study shows updated rotavirus vaccine not linked to increase in bowel obstruction
Date:1/4/2012

The rotovirus vaccine was pulled from the marketplace in 1999 after being associated with painful gastrointestinal complications, however, the updated rotavirus vaccines do not appear to increase the occurrence of these potentially fatal side effects, according to a new study by child health experts at C.S. Mott Children's Hospital.

The two updated versions of the vaccine,re-introduced in 2006 and 2008, prevent infection by rotavirus, which causes vomiting, abdominal pain, severe diarrhea and frequently requires hospitalization for young infants and children. Rotavirus was once the leading cause of gastrointestinal illness among children in the U.S.

The new study, published in this week's Archives of Pediatric Adolescent Medicine, shows the re-introduction of the vaccine has not caused an increase in a severe bowel obstruction called intussusception, the side effect that led to the original vaccine's withdrawal.

"We always need to carefully weigh the risks and benefits of childhood vaccines. Fortunately, our results suggest that rotavirus vaccines have not increased the rate of intussusception in the U.S.," says pediatrician Joe Zickafoose, M.D., M.S., a research fellow with the Child Health Evaluation and Research Unit.

Recent international studies have shown that, among vaccinated infants, the two latest rotavirus vaccines may be associated with a small increase in cases of intussusception.

However, the re-introduction of rotavirus vaccines in the United States did not appear to increase the rate of hospitalizations for intussusception.

More than 70 percent of infants in the U.S. have been vaccinated against rotavirus. The re-introduction of rotavirus vaccines is credited with reducing the number of diarrhea-related outpatient visits, emergency department visits, and hospitalizations among children.

Data used in the study came from the Healthcare Cost and Utlization Project's Kids' Inpatient Database, which is a sample of 80 percent of national pediatric discharges. The study focused on children younger than 1-year-old based on previous data which showed the most cases on intussusception occur within weeks of the vaccine being administered at ages 2-months, 4-months and 6-months old.

The investigators examined data trends from the decade prior to vaccine re-introduction, 1997-2006, and then made comparisons to data after vaccine re-introduction.

When comparing data, investigators expected to see 36 intussusception-related hospitalizations per 100,000 children under 1-year-old by 2009.

Despite the re-introduction of the vaccines, there were only 33.3 hospitalizations per 100,000 children in 2009, making it very unlikely that the vaccines led to additional cases.

The latest versions of the rotavirus vaccine were licensed following studies in over 70,000 children, which showed no increased risk for intussusception among those vaccinated. However, there has been lingering concern that a small amount of risk may have been missed in these studies.

"We hope that our study provides information that will continue to reassure parents that the benefits of rotavirus vaccine outweigh the risks," says Zickafoose, lead author of the study.


'/>"/>
Contact: Lauren McLeod
lemcleod@med.umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Related medicine news :

1. U.S. Heart Attack Patients Readmitted Most Often: Study
2. Nap-deprived tots may be missing out on more than sleep, says University of Colorado-led study
3. Womens Sexual Satisfaction Often Rises With Age: Study
4. BINGO! game helps researchers study perception deficits
5. Genetic predisposition to disease common in 2 supercentenarians: New study
6. Study Looks at Deep Brain Stimulation in Bipolar Patients
7. Study finds another potential risk factor for developing dementia and Alzheimers disease in women
8. Study evaluates effects of marijuana ingredients on brain functioning during visual stimuli
9. Gene Mutations Linked to Thyroid Cancer Risk: Study
10. U.S. Blacks More Likely to Die of Colon Cancer Than Whites: Study
11. Multiple Sclerosis May Cause Changes in Thalamus: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... , ... October 13, 2017 , ... Many families have ... many long-term care insurance companies have a waiver for care if the client has ... period, when the family pays for care, is often waived, so the benefits from ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Ellevate Network, ... in business to advocate for action towards gender equality at their inaugural Summit in ... around the globe, and reached a social audience of over 3 million. To watch ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer ... one of the most popular and least understood books in the Holy Scriptures, Revelation. ... descriptions that have baffled scholars for centuries. Many have tossed it off as mere ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader ... been awarded a contract by the Center for Medicare and Medicaid Services (CMS). ... the enterprise use of Agile methodologies in a consistent and high value manner ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian ... On The Brink” is the creation of published author, William Nowers. Captain Nowers ... a WWII veteran, he spent thirty years in the Navy. Following his career ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... -- Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided an ... Puerto Rico , where the company ... Following a comprehensive onsite assessment, ... damage, temporary loss of power and minimal water damage ... operations have resumed, and the company expects to return ...
(Date:10/10/2017)... --  West Pharmaceutical Services, Inc. (NYSE: WST), a ... today shared the results of a study highlighting the ... administration of polio vaccines. The study results were presented ... by Dr. Ondrej Mach , Clinical Trials and ... and recently published in the journal Vaccine. i ...
(Date:10/5/2017)... 2017  In response to the nationwide opioid ... Surgeons (AAOMS) released prescribing recommendations that urge ibuprofen ... as a first-line therapy to manage a patient,s ... Recognizing the value and importance of ... Prescribing: Acute and Postoperative Pain Management" stresses that ...
Breaking Medicine Technology: