Navigation Links
U-M study challenges notion of using Herceptin only for HER2-positive breast cancer
Date:2/26/2013

percent to 5 percent of all the cells in a tumor. They are resistant to current chemotherapy and radiation treatments but since they express HER2, they are effectively targeted by Herceptin.

Further, the researchers in this new study found that for tumors classified as HER2-negative, HER2 levels were higher in bone metastases compared to the primary breast tumor. Bone is the most frequent site to which breast cancer spreads.

The researchers administered Herceptin to mice with these bone lesions and found that it was most effective when given early, when tumors were small or mere "micrometastases." In these cases, Herceptin almost completely blocked the tumors from growing. When the drug was given later, after tumors were established, it had little effect.

"We have shown that the bone microenvironment induces HER2 expression in these tumors. If Herceptin can target bone micrometastases, then administering it to patients before metastases develop could help reduce tumor recurrence," says study author Hasan Korkaya, Ph.D., research assistant professor of internal medicine at the U-M Medical School.

The implications of this finding are that we need cancer treatments that target the small number of cancer stem cells in addition to traditional chemotherapies that eliminate the bulk tumor cells. This means that merely looking at whether a tumor shrinks is not good enough to determine whether the treatment will have long term benefit.

"This work has very significant implications for how we have developed adjuvant therapies. The idea of using drugs that cause tumors to shrink, which has been the accepted paradigm for developing therapies, is flawed. Our work suggests that adjuvant therapies will need to target the cancer stem cell population. Eliminating cancer stem cells by effective adjuvant therapies should prevent tumor recurrence, ultimately resulting in more cures," Wicha says.


'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
U-M study challenges notion of using Herceptin only for HER2-positive breast cancer
(Date:7/25/2014)... CA (PRWEB) July 25, 2014 AttorneyOne.com, a ... the latest information from the FDA on Ibuprofen and ... 21, that one lot of Ibuprofen and one lot of ... due to mislabeled packaging. Oxcarbazepine is used for the ... , The reason for the recall is that ...
(Date:7/25/2014)... 2014 A new study of participants in ... are published today in Cancer , found evidence that ... who had an abnormal finding on a lung cancer screening ... life than did those who were screened and found to ... to the researchers. “We expected that participants with an abnormal ...
(Date:7/25/2014)... TX (PRWEB) July 25, 2014 ... the current state of the Galactooligosaccharides (GOS) ... a basic overview of the industry, including definitions, ... and Chinese domestic market analysis are provided with ... landscape of the market. A comparison between the ...
(Date:7/25/2014)... July 24, 2014 (HealthDay News) -- Shift workers, especially men, ... to people not on such schedules, a new study suggests. ... work on a set schedule, with shifts moving around at ... at all surprising," said one expert, Dr. Alan Manevitz, a ... "Physicians have long known that working shifts disrupts many ...
(Date:7/25/2014)... -- A new system that sent patients to designated ... victims of sudden cardiac arrest in Arizona, according to ... of Emergency Medicine . , "We knew lives ... cutting edge guidelines for post-cardiac arrest care and we ... hospitals, similar to what is done for Level 1 ...
Breaking Medicine News(10 mins):Health News:Ibuprofen and Oxcarbazepine Tablets Recalled: AttorneyOne Monitors and Keep Consumers Informed 2Health News:Full Explanation Reduces Seniors’ Worries about Lung Cancer Screening 2Health News:Full Explanation Reduces Seniors’ Worries about Lung Cancer Screening 3Health News:Full Explanation Reduces Seniors’ Worries about Lung Cancer Screening 4Health News:Full Explanation Reduces Seniors’ Worries about Lung Cancer Screening 5Health News:GOS Market (Galacto-oligosaccharides) Development in Global & China Regions Now Available at DeepResearchReports.com 2Health News:GOS Market (Galacto-oligosaccharides) Development in Global & China Regions Now Available at DeepResearchReports.com 3Health News:Study Links Shift Work to Risk for Type 2 Diabetes 2Health News:Study Links Shift Work to Risk for Type 2 Diabetes 3Health News:New EMS system in Arizona dramatically improves survival from cardiac arrest 2Health News:New EMS system in Arizona dramatically improves survival from cardiac arrest 3
... People with a mild fear of flying should take ... their breath for six to 10 seconds, just before ... Professional Association of German Psychiatrists (known by its German ... takes the mind off one's fears. ,BVDP ...
... order to prevent discrimination against the people suffering from ... on potential employees. // ,Satyam is the ... test on candidates selected for jobs in its various ... we have stopped conducting the HIV/AIDS test to protect ...
... provide free care to the poor has dropped over ... problem for America’s quickly growing number of uninsured people. ... the Center for Studying Health System Change, released on ... the mid-1990s, compared with about two-thirds now. This is ...
... down. The industry across the country is now facing a suicide ... the country, small farmers are scared due to low prices. // ... Rs 5 for one kg of chicken from Rs 1.80 and ... being forced to commit suicide. K Narayana Reddy, president, of Andhra ...
... offer a pay of nearly $500,000 to the head of ... proposal, the Queensland Opposition has described it as being extravagant ... advertised for the post of a new director for the ... $500,000-plus. This is believed to pave way for enormous ...
... person who had popularized country music in the United States ... died on // Saturday. He was 76., ,Owens' family said ... according to the website of a concert hall and restaurant he ... Aug 12, 1929, in Texas to a poor farming family, Alvis ...
Cached Medicine News:Health News:Satyam Stops Conducting HIV Tests On Employees To Prevent Discrimination 2Health News:Fewer Doctors Treating For Free 2
(Date:7/25/2014)... Cardinal Health will today name three of the nation,s ... Independent Pharmacy Best Practices Competition, during the company,s ... gatherings of independent pharmacists. The Best ... Ohio , Tennessee and ... implementing exceptionally creative methods that demonstrate how independent pharmacies ...
(Date:7/25/2014)... N.Y. and MEXICO CITY , July 25, 2014 ... that PLM, a Latin American healthcare sciences publisher, launched ... medical information on conditions such as cancer and heart ... access the most up-to-date information to deliver better patient ... is growing rapidly, with many relying on smartphones and ...
(Date:7/25/2014)...  Semler Scientific, Inc. (Nasdaq: SMLR ... that develops patented products that assist healthcare providers ... reported financial results for the second quarter and ... "The second quarter of 2014 continued to ... , M.D., chief executive officer of Semler.  "We ...
Breaking Medicine Technology:Cardinal Health Announces Three Best Practice Winners for Leading Change in Community Pharmacy 2Cardinal Health Announces Three Best Practice Winners for Leading Change in Community Pharmacy 3Cardinal Health Announces Three Best Practice Winners for Leading Change in Community Pharmacy 4Cardinal Health Announces Three Best Practice Winners for Leading Change in Community Pharmacy 5Cardinal Health Announces Three Best Practice Winners for Leading Change in Community Pharmacy 6Healthcare Sciences Publisher PLM and IBM Speed Access to Medical Information to Deliver Better Patient Care with Mobile 2Healthcare Sciences Publisher PLM and IBM Speed Access to Medical Information to Deliver Better Patient Care with Mobile 3Healthcare Sciences Publisher PLM and IBM Speed Access to Medical Information to Deliver Better Patient Care with Mobile 4Semler Reports Second Quarter 2014 Financial Results 2Semler Reports Second Quarter 2014 Financial Results 3
... Oct. 29 Ferring Pharmaceuticals Inc. announces the appointment ... for Orthopaedics. Dr. Kovelman will be responsible for ... treatment for knee pain due to osteoarthritis, as well ... Kovelman is exceptionally well qualified to fill this role," ...
... NANJING, China, Oct. 29 /PRNewswire-Asia/ -- Simcere Pharmaceutical ... a leading pharmaceutical company,specializing in the development, manufacturing, ... China, today announced that it has,entered into an ... a Cayman,Islands company that, as its sole business, ...
Cached Medicine Technology:Dr. Harry Kovelman Joins Ferring Pharmaceuticals as Associate Medical Director for Orthopaedics 2Dr. Harry Kovelman Joins Ferring Pharmaceuticals as Associate Medical Director for Orthopaedics 3Simcere Pharmaceutical Group to Acquire Additional Stake in Jiangsu Yanshen Biological Technology Stock Co., Ltd. 2Simcere Pharmaceutical Group to Acquire Additional Stake in Jiangsu Yanshen Biological Technology Stock Co., Ltd. 3
... practices performing routine Holter,monitoring, the ... Wizard provides a,practical, no-nonsense diagnostic ... health care,environment. This highly accurate ... a variety,of configurations at a ...
... Burdick EK-10 single-channel,electrocardiograph features ... membrane keypad. It provides ... a quick and,accurate diagnosis. ... with a built in ...
The CSV-1000ETDRS10% test face presents the standard ETDRS test at a contrast level of 10%. This test is widely used in clinical studies for the evaluation of refractive surgery and contact lenses....
... test face is used widely for screening ... LogMAR acuity from 20/10 to 20/100 and ... cycles/degree. , ,The patient can be easily ... acuity and contrast sensitivity. If a contrast ...
Medicine Products: