Navigation Links
U-M study challenges notion of using Herceptin only for HER2-positive breast cancer
Date:2/26/2013

ANN ARBOR, Mich. New research from the University of Michigan Comprehensive Cancer Center finds that the protein HER2 plays a role even in breast cancers that would traditionally be categorized as HER2-negative and that the drug Herceptin, which targets HER2, may have an even greater role for treating breast cancer and preventing its spread.

About 20 percent of women with breast cancer have tumors labeled HER2-positive. And since the drug Herceptin has come on the scene, it has had a tremendous impact on survival for these women, particularly when it is given in the adjuvant setting, after surgery to remove the primary cancer. The new findings have potential implications for an additional 65 percent of women with breast cancer.

A recent study based on new analyses of old data found some tumors were incorrectly categorized as HER2-positive and as a result those women received adjuvant Herceptin. It turns out, they benefited as much from the treatment as woman with actual HER2-positive cancer.

"We now provide a molecular explanation for the surprising finding that adjuvant Herceptin benefited some women with HER2-negative breast cancer. If this is confirmed in clinical trials, it could alter our approach to breast cancer treatment," says study author Max S. Wicha, M.D., distinguished professor of oncology and director of the U-M Comprehensive Cancer Center.

At this point, patients with HER2-negative breast cancer are not advised to take Herceptin.

The explanation is that HER2 is selectively expressed in the cancer stem cells of many HER2-negative breast tumors. Because the stem cells represent such a small number of cells in a tumor, the amount of HER2 is not high enough to meet the threshold for a HER2-positive cancer.

The researchers had previously shown HER2 plays an important role in cancer stem cells the small number of cells in a tumor that fuel its growth and spread. These cells represent 1
'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
U-M study challenges notion of using Herceptin only for HER2-positive breast cancer
(Date:10/1/2014)... Wi (PRWEB) October 01, 2014 UP4 ... of UP4 WOMEN’S probiotic to The National Network to ... of October. This organization was chosen through nationwide polling ... website and social media outlets. , “We are ... receive a portion of every sale of UP4 Women’s ...
(Date:10/1/2014)... This weekend Pope Francis drew world-wide attention to the problem ... seniors in St. Peter's Square in the Vatican, he decried ... the elderly is as inhuman as that against children," Pope ... discarded, victims of an abandonment that is tantamount to hidden ... is hurting our world so much," he said. , His ...
(Date:10/1/2014)... Los Angeles, CA (PRWEB) October 01, 2014 ... buyer power score of 3.1 out of 5, ... freezer users include food and beverage manufacturers, food ... manufacturers. As a result of these users' diversity, ... growth. As such, rising industrial production, consumer spending ...
(Date:10/1/2014)... 01, 2014 Nearly a year-and-a-half after ... County District Court jury awarded him $4.75 million; Michael ... years old. Casper had been too sick to ... According to the Court Documents (District Court, Pueblo County ... a benign non-cancerous condition of his prostate, when he ...
(Date:9/30/2014)... (HealthDay News) -- There,s no genetic evidence that high ... a new study says. Some previous research had ... people against type 2 diabetes, raising the possibility of ... sugar disease. In this study, British researchers investigated ... focusing on genes that control blood levels of vitamin ...
Breaking Medicine News(10 mins):Health News:UP4 Probiotics Partners with The National Network to End Domestic Violence 2Health News:Pope Francis Shines New Spotlight on Neglect of Elderly, Survey Finds Elder Self-Neglect is a Growing and Hidden Problem in U.S. says NAPGCM 2Health News:Pope Francis Shines New Spotlight on Neglect of Elderly, Survey Finds Elder Self-Neglect is a Growing and Hidden Problem in U.S. says NAPGCM 3Health News:Industrial Freezers Procurement Category Market Research Report Now Available from IBISWorld 2Health News:Industrial Freezers Procurement Category Market Research Report Now Available from IBISWorld 3Health News:Industrial Freezers Procurement Category Market Research Report Now Available from IBISWorld 4Health News:Law Offices of D.R. Jones Client Wins 4.7 Million Dollar Verdict, Insurance Company Files Motion for a New Trial 2Health News:Law Offices of D.R. Jones Client Wins 4.7 Million Dollar Verdict, Insurance Company Files Motion for a New Trial 3Health News:Gene Study Finds No Proof Vitamin D Guards Against Type 2 Diabetes 2
... Mii amo, a destination spa,at Enchantment Resort, for ... the winter solstice on December 21. Activities include ... Native,American Program Director R.J. Joseph and special guest, ... Elder from the Blood Reserve,in Standoff, Alberta, Canada,s ...
... planned bequest comes at stem cell symposium, ANN ... retail pioneer A. Alfred Taubman announced a $22 million ... research institute aimed at,understanding, treating and preventing human disease., ... it again --,announcing that he will bequeath an additional ...
... a Man Wanted to Know But Was Afraid to ... 4.3 million babies born,in the U.S. each year but ... BEING DAD is a revealing, entertaining and inspirational DVD ... who,have recently gone through the pregnancy and delivery process. ...
... developed a magnetic resonance imaging (MRI)-based method for detecting and ... in patients who have undergone a procedure to treat atrial ... Oct. 7, 2008, issue of the Journal of the ... is an arrhythmia, or abnormal heart rhythm, that involves the ...
... (OTCBB:WYND), the ideas-to-revenues social media company, announced ... www.muveinc.com ), to create an interactive marketing ... corporate wellness program. Wyndstorm,s design project will ... use of wellness programs among employees via ...
... 7 The Catholic Health,Association of the United ... (CHI), Denver; Covenant Health Systems, Lexington, MA;,and Trinity ... effort to,raise awareness about global climate change., ... National Religious,Partnership for the Environment (NRPE) and the ...
Cached Medicine News:Health News:Mii amo Honors Winter Solstice With Traditional Native American Celebration December 18-21 2Health News:Alfred Taubman Announces New $22M Gift to U-M 2Health News:BEING DAD DVD Offers a Sneak Peek at Pregnancy From a Guy's Point of View 2Health News:Novel imaging approach may assist in predicting success of treatment for atrial fibrillation 2Health News: 3D Social Media Application Aims to Cut Workplace Obesity : Muve, Inc., Selects Social Media Developer Wyndstorm Corporation to Design Online Promotions for Corporate Wellness Program 2Health News: 3D Social Media Application Aims to Cut Workplace Obesity : Muve, Inc., Selects Social Media Developer Wyndstorm Corporation to Design Online Promotions for Corporate Wellness Program 3Health News:Catholic Health Organizations Launch Ministry-Wide Effort to Raise Awareness About Global Climate Change 2
(Date:9/30/2014)... Sept. 30, 2014 Arbor Pharmaceuticals, LLC. ... Global Markets Direct,s, ,Arbor Pharmaceuticals, LLC. - ... of the Arbor Pharmaceuticals, LLC.,s pharmaceutical research and ... on the current therapeutic developmental pipeline of Arbor ... stages, therapeutics assessment by drug target, mechanism of ...
(Date:9/30/2014)... DENVER , Sept. 30, 2014  According ... "the world of cancer clinical trials is going ... clinical trials and the work of the current ... these types of ,next generation, clinical trials, which ... tomorrow."  The company has been ...
(Date:9/30/2014)... , Sept. 30, 2014 A study ... (OCT), offered a new look at the composition of ... how physicians understand and treat the disease, a leading ... at Baptist Health Lexington between September 2010 and May ... the Journal of the American College of Cardiology ...
Breaking Medicine Technology:Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 2Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 3Small Denver Company Pharmatech driving a large revolution in how cancer clinical trials are managed 2New Imaging Tool May Allow Tailoring of Stroke Prevention to Each Patient 2
... Combination with CRESTOR (rosuvastatin calcium) Demonstrates Similar Lipid Effects ... ... Population, SAN FRANCISCO, June 7 ... type 2 diabetes,that were enrolled in a Phase III study showed ...
... the ADA,s Annual Scientific Sessions, SAN FRANCISCO, ... of the dose-finding study for its new,injectable diabetes ... American Diabetes Association,s (ADA) 68th Annual Scientific Sessions,meeting ... that AVE0010 was well tolerated and significantly,improved glycemic ...
Cached Medicine Technology:Abbott's Phase III Sub-Group Analysis Shows Investigational TriLipix(TM) in Combination with CRESTOR(R) Improves Key Lipids in Patients with Mixed Dyslipidemia and Type 2 Diabetes 2Abbott's Phase III Sub-Group Analysis Shows Investigational TriLipix(TM) in Combination with CRESTOR(R) Improves Key Lipids in Patients with Mixed Dyslipidemia and Type 2 Diabetes 3Abbott's Phase III Sub-Group Analysis Shows Investigational TriLipix(TM) in Combination with CRESTOR(R) Improves Key Lipids in Patients with Mixed Dyslipidemia and Type 2 Diabetes 4New Diabetes Compound AVE0010 Showed Clear Dose Response Results With Once-A-Day Injection in Phase IIb Study 2New Diabetes Compound AVE0010 Showed Clear Dose Response Results With Once-A-Day Injection in Phase IIb Study 3New Diabetes Compound AVE0010 Showed Clear Dose Response Results With Once-A-Day Injection in Phase IIb Study 4
DNA/RNA preparation in 8-multi channels...
... units with hydrophobic PTFE membranes,Millex filter ... ideal for the sterilizing filtration of ... and for sterilizing or clarifying organic ... filter units are available with different ...
... Bottled Water, The Simplicity personal water system ... currently use bottled water. In addition to ... store bottled water, your laboratory applications may ... be absorbed from containers and cause water ...
... of Type I ultrapure water, , Ultrapure ... System is designed to provide the "final ... by reverse osmosis, distillation or deionization. Super-Q ... which exceeds Type I ASTM/CAP/NCCLS specifications.,The Super-Q ...
Medicine Products: