Navigation Links
U-M scientists slow development of Alzheimer's trademark cell-killing plaques
Date:3/17/2014

ANN ARBORUniversity of Michigan researchers have learned how to fix a cellular structure called the Golgi that mysteriously becomes fragmented in all Alzheimer's patients and appears to be a major cause of the disease.

They say that understanding this mechanism helps decode amyloid plaque formation in the brains of Alzheimer's patientsplaques that kills cells and contributes to memory loss and other Alzheimer's symptoms.

The researchers discovered the molecular process behind Golgi fragmentation, and also developed two techniques to 'rescue' the Golgi structure.

"We plan to use this as a strategy to delay the disease development," said Yanzhuang Wang, U-M associate professor of molecular, cellular and developmental biology. "We have a better understanding of why plaque forms fast in Alzheimer's and found a way to slow down plaque formation."

The paper appears in an upcoming edition of the Proceedings of the National Academy of Sciences. Gunjan Joshi, a research fellow in Wang's lab, is the lead author.

Wang said scientists have long recognized that the Golgi becomes fragmented in the neurons of Alzheimer's patients, but until now they didn't know how or why this fragmentation occurred.

The Golgi structure has the important role of sending molecules to the right places in order to make functional cells, Wang said. The Golgi is analogous to a post office of the cell, and when the Golgi becomes fragmented, it's like a post office gone haywire, sending packages to the wrong places or not sending them at all.

U-M researchers found that the accumulation of the Abeta peptidethe primary culprit in forming plaques that kill cells in Alzheimer's brainstriggers Golgi fragmentation by activating an enzyme called cdk5 that modifies Golgi structural proteins such as GRASP65.

Wang and colleagues rescued the Golgi structure in two ways: they either inhibited cdk5 or expressed a mutant of GRASP65 that cannot be modified by cdk5. Both rescue measures decreased the harmful Abeta secretion by about 80 percent.

The next step is to see if Golgi fragmentation can be delayed or reversed in mice, Wang said. This involves a collaboration with the Michigan Alzheimer's Disease Center at the U-M Health System, directed by Dr. Henry Paulson, professor of neurology, and Geoffrey Murphy, assistant professor of physiology and research professor at the U-M Molecular and Behavioral Neuroscience Institute.

The collaboration was made possible by MCubed, a two-year seed funding program to fuel interdisciplinary teams of U-M faculty to pursue research with major societal impact.


'/>"/>

Contact: Laura Bailey
baileylm@umich.edu
734-647-1848
University of Michigan
Source:Eurekalert

Related medicine news :

1. Scientists solving the mystery of human consciousness
2. Scientists uncover multiple faces of deadly breast cancer
3. Scientists identify major source of cells defense against oxidative stress
4. Scientists tailor cell surface targeting system to hit organelle ZIP codes
5. Scientists rewrite rulebook on breast cancer in landmark global study
6. Warwick scientists uncover how checkpoint proteins bind chromosomes
7. NIH scientists link quickly spreading gene to Asian MRSA epidemic
8. Joslin scientists identify important mechanism that affects the aging process
9. Scripps Research scientists show how memory B cells stay in class to fight different infections
10. Scientists Map Melanomas Genome
11. A*STAR scientists discover switch to boost anti-viral response to fight infectious diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... ... January 19, 2017 , ... St. Catherine’s Village announced that ... Center is a skilled nursing facility on the grounds of the St. Catherine’s Village ... recently was voted the best nursing home in Mississippi for the second year in ...
(Date:1/19/2017)... CA (PRWEB) , ... January 19, 2017 , ... ... taken in the 2017 Spring Create Real Impact contest from Impact Teen Drivers ... 17 at http://www.createrealimpact.com . , Educational grants totaling $15,000 will be ...
(Date:1/19/2017)... ... January 18, 2017 , ... The CHP suggests that California drivers ... storm by slowing down and increasing the space between themselves and other vehicles, according ... car accident attorney Raymond R. Hassanlou notes that, rain or shine, drivers should always ...
(Date:1/19/2017)... , ... January 19, 2017 , ... Connecticut Dermatology Group ... Kim, a highly experienced and compassionate dermatologist. Dr. Kim brings an extensive background ... , “It is with considerable pleasure to welcome back Dr. Kim to the CDG ...
(Date:1/19/2017)... ... ... Sales Focus Inc. (SFI), a Maryland-based sales outsourcing company, announced today that it ... years SFI has been recognized as the world’s leader in Intelligent Sales Outsourcing Solutions. ... market. The new clients include: Panacea Pro, Campseekers, Contentmart, Stress Pal, Ariello, Inc. ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... Jan. 18, 2017  Aprima Medical Software, a ... practice management (PM) and revenue cycle management (RCM) ... of a former reseller Healthcare Data Solutions (HDS) ... agreement, Aprima will assume full support for HDS,s ... medical practices across 15 states. Financial terms were ...
(Date:1/18/2017)... -- Research and Markets has announced the addition of the ... Global Opportunity Analysis and Industry Forecast, 2014-2022" report to their offering. ... Vital signs monitoring market ... $5,491 million by 2022, growing at a CAGR of 5.8% from 2016 ... the leading regional market in global vital signs monitoring devices industry. The ...
(Date:1/18/2017)... , Jan. 18, 2017  Adaptive Sound Technologies, Inc. (ASTI), ... new partnership with Hyatt Place Nashville/Downtown to deliver the ... LectroFan sleep therapy machines in over two hundred of ... most important parts of having a great stay is ... of Hyatt Place Nashville/Downtown. "We,re pleased to be able ...
Breaking Medicine Technology: