Navigation Links
U-M scientists find potential driver of some aggressive prostate cancers
Date:4/4/2011

ANN ARBOR, Mich. Researchers at the University of Michigan Comprehensive Cancer Center have identified a genetic anomaly that may drive the aggressive spread of a rare subset of prostate cancers.

They found mutations of a gene called KRAS, which is known to play a role in numerous cancers but is rarely associated with prostate cancer. The mutation in which two pieces of the chromosome change places and fuse together was seen only in metastatic prostate cancer, an advanced form in which the disease has spread to distant parts of the body.

"This study suggests that in a rare subset of prostate cancers, KRAS rearrangement acts as a mechanism that may promote tumor progression. We speculate that prostate cancers with this rearrangement are more aggressive, since we have found them only in metastatic disease," says senior study author Arul Chinnaiyan, M.D., Ph.D., director of the Michigan Center for Translational Pathology and a Howard Hughes Medical Institute Investigator.

Results of the study appear in Cancer Discovery, a new journal from the American Association for Cancer Research.

In 2005, Chinnaiyan and his team identified a prostate-specific gene called TMPRSS2 that fuses with a cancer-causing gene called ERG. In this new study, the researchers found the KRAS gene fusion occurred only in cells that did not have the more common gene fusion. The team also discovered in 2010 gene fusions that occur in a pathway called RAF.

"This suggests that prostate cancer can find different ways to activate a molecular pathway by creating gene rearrangements in at least these three ways," says Chinnaiyan, S.P. Hicks Endowed Professor of Pathology at the U-M Medical School.

This implies that, like breast cancer, prostate cancer likely has different subtypes that will need different, targeted treatment strategies. Chinnaiyan estimates the KRAS rearrangement occurs in 1 percent of prostate cancers, but may represent a higher percentage of metastatic prostate cancer.


'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
U-M scientists find potential driver of some aggressive prostate cancers
(Date:5/24/2016)... , ... May 24, 2016 , ... Sterling Global Products ... a unique and patented refillable hanging wipe dispenser. The campaign kick-off video is located ... will end June 25, 2016. The goal is to raise $1,000 per day for ...
(Date:5/24/2016)... IL (PRWEB) , ... May 24, 2016 , ... To ... created a new research award to examine gender differences in lung cancer. Today, the ... Research Innovation Project: Lung Cancer in Women Award, funded by the American Lung Association’s ...
(Date:5/24/2016)... (PRWEB) , ... May 24, 2016 , ... ... debuted a new corporate identity and website at its “Transforming Outcomes” User Conference ... other marketing enhancements reflect i2i’s ongoing success to set the market standard for ...
(Date:5/24/2016)... (PRWEB) , ... May 24, ... ... nationwide provider of communication enabled solutions and managed services today announced a ... for the enterprise contact center market. , Altura, one of Avaya’s largest ...
(Date:5/24/2016)... Falls Church, VA (PRWEB) , ... May 24, 2016 , ... ... June 14-15, 2016 · Raleigh, NC, http://www.fdanews.com/humanerrordrugdevice , Human error is known ... it is unlikely that human error will ever be totally eliminated, many human performance ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... 2016 Een app die artsen ... collectief patiënten kunnen behandelen, hun kennis kunnen delen en ... de nieuwe en revolutionaire MDLinking App, ontwikkeld door een ... dr. Hans Flu en oncologisch chirurg dr. Gijs ... is, wordt op dinsdag 24 mei officieel gepresenteerd op ...
(Date:5/23/2016)... 23, 2016 According to ... Development, Growth and Demand Forecast to 2022 - ... by Application (Drug Discovery and Development, Proteomics, Clinical ... Life Science and Biotechnology, Academic and Research Institute, ... the global mass spectrometry market was ...
(Date:5/23/2016)... , May 23, 2016 Gamida ... the treatment of cancer and orphan genetic diseases, announced ... to $4.4 million from the Israel Innovation Authority (formerly ... Ministry of Economy and Industry. The mission of the ... in various industries, including science and technology, while stimulating ...
Breaking Medicine Technology: