Navigation Links
U-M scientists find potential driver of some aggressive prostate cancers
Date:4/4/2011

ANN ARBOR, Mich. Researchers at the University of Michigan Comprehensive Cancer Center have identified a genetic anomaly that may drive the aggressive spread of a rare subset of prostate cancers.

They found mutations of a gene called KRAS, which is known to play a role in numerous cancers but is rarely associated with prostate cancer. The mutation in which two pieces of the chromosome change places and fuse together was seen only in metastatic prostate cancer, an advanced form in which the disease has spread to distant parts of the body.

"This study suggests that in a rare subset of prostate cancers, KRAS rearrangement acts as a mechanism that may promote tumor progression. We speculate that prostate cancers with this rearrangement are more aggressive, since we have found them only in metastatic disease," says senior study author Arul Chinnaiyan, M.D., Ph.D., director of the Michigan Center for Translational Pathology and a Howard Hughes Medical Institute Investigator.

Results of the study appear in Cancer Discovery, a new journal from the American Association for Cancer Research.

In 2005, Chinnaiyan and his team identified a prostate-specific gene called TMPRSS2 that fuses with a cancer-causing gene called ERG. In this new study, the researchers found the KRAS gene fusion occurred only in cells that did not have the more common gene fusion. The team also discovered in 2010 gene fusions that occur in a pathway called RAF.

"This suggests that prostate cancer can find different ways to activate a molecular pathway by creating gene rearrangements in at least these three ways," says Chinnaiyan, S.P. Hicks Endowed Professor of Pathology at the U-M Medical School.

This implies that, like breast cancer, prostate cancer likely has different subtypes that will need different, targeted treatment strategies. Chinnaiyan estimates the KRAS rearrangement occurs in 1 percent of prostate cancers, but may re
'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
U-M scientists find potential driver of some aggressive prostate cancers
(Date:8/1/2015)... ... August 01, 2015 , ... Calvary Hospital today announced that it ... Bronx campus. The goal is to bring this Torah – dating from 1880 – ... rituals and religious services. , Scroll No. 515, from the town of Taus-Domazlice, ...
(Date:8/1/2015)... ... , ... On Tuesday, July 28th, Symantec released a security industry whitepaper ... the attack on Anthem Inc. which resulted in one of the largest data breaches ... spear phishing campaigns. , For Joe Caruso, founder and CEO/CTO of ...
(Date:8/1/2015)... ... August 01, 2015 , ... On March 19, 2015 Phil Valentine – the Executive ... the Appalachian Trail by stepping off Springer Mountain and heading north. Since that ... 26th Phil reached Connecticut and was greeted by friends and family. He visited CCAR ...
(Date:7/31/2015)... ... August 01, 2015 , ... The Honor Society of Nursing, Sigma ... the Future of Nursing (GAPFON) 20-21 July 2015 in San Juan, Puerto Rico. Key ... meeting. , Dr. Silvia Cassiani, Advisor, Nursing and Allied Health Personnel Development, Unit of ...
(Date:7/31/2015)... , ... July 31, 2015 , ... ... industry players to know in predictive health analytics , Jvion continues to ... The firm creates predictive software that targets patient and population level illness to ...
Breaking Medicine News(10 mins):Health News:Calvary Hospital Announces Plans to Restore Historic Torah 2Health News:Calvary Hospital Announces Plans to Restore Historic Torah 3Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 2Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 3Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 4Health News:Connecticut Executive Hikes Appalachian Trail to Raise Awareness About Recovery. 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 3Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 4Health News:Jvion Showcased as Leader in the Predictive Analytic Market 2
... Healthy Kitchen, Healthy Lives engages a variety of health ... at The Culinary Institute of America , Greystone ... education conference that fosters a connection between nutrition science, ... Wellness Council is a participant in the event which ...
... Autism Awareness Day VILLANOVA, Pa. and 15 Centers Nationwide, April ... the likelihood of an autism diagnosis is four times that of ... than with cancer, diabetes and AIDS combined, yet startlingly, many parents ... in their children or where to turn for help when those ...
... April 1 Medicare beneficiaries who need physical ... efficient to obtain treatment under legislation introduced yesterday ... Patient Access to Physical Therapists Act (HR 1829), ... (R-PA), and Tammy Baldwin (D-WI), eliminates the need ...
... 2009 (BRONX, NY) Scientists at Albert Einstein College ... theory of autism that suggests that the brains of people ... the disorder might be reversible. , The central ... Brain Research Reviews , is that autism is a ...
... Sutter Health network of doctors, hospitals and other health ... health care quality according to the respected Lewin Group, ... The Lewin Group produces rankings of America,s 120 largest ... satisfaction data from 2007, as reported by the Centers ...
... April 1 Edifecs announced ... implementation issues that providers, payers, clearinghouses and other healthcare ... new standards. In these sessions, Edifecs will offer ... Edifecs5010(TM) Migration -- a comprehensive set of products, online ...
Cached Medicine News:Health News:Tomato Products Wellness Council Joins Harvard Medical School and the Culinary Institute of America to Take Part in Healthy Kitchen, Healthy Lives April 2-5, 2009 2Health News:Tomato Products Wellness Council Joins Harvard Medical School and the Culinary Institute of America to Take Part in Healthy Kitchen, Healthy Lives April 2-5, 2009 3Health News:National Experts Offer Practical Tips for Parents Concerned about Autism 2Health News:National Experts Offer Practical Tips for Parents Concerned about Autism 3Health News:Legislation Aims to Increase Access to Physical Therapist Services By Eliminating Physician Referral Requirement 2Health News:Legislation Aims to Increase Access to Physical Therapist Services By Eliminating Physician Referral Requirement 3Health News:Einstein scientists propose new theory of autism 2Health News:Einstein scientists propose new theory of autism 3Health News:Sutter Health Ranks Tops in California for Quality Health Care 2Health News:Edifecs Launches First of a Series of Edifecs5010(TM) Migration Educational Webinars Addressing 5010 Migration Challenges, Opportunities and Solutions 2Health News:Edifecs Launches First of a Series of Edifecs5010(TM) Migration Educational Webinars Addressing 5010 Migration Challenges, Opportunities and Solutions 3
(Date:7/31/2015)... SAN DIEGO , July 31, 2015  Eisai ... Ltd. (Headquarters: Tokyo , President and ... Inc. (Headquarters: San Diego, California , ... HALO") have signed a clinical collaboration agreement to evaluate ... in combination with Halozyme,s investigational drug PEGPH20 (PEGylated recombinant ...
(Date:7/31/2015)... , July 31, 2015 According ... Market by Product (Bioimpedance Analyzers (BIA), Dual-Energy X-ray Absorptiometry ... Weighing) - Global Analysis & Forecast to 2019", published ... pegged at $911.1 Million 2014 and is estimated to ... CAGR of 9.4% from 2014 to 2019. ...
(Date:7/30/2015)... , July 30, 2015 Edwards Lifesciences Corporation (NYSE: ... heart valves and hemodynamic monitoring, today announced that Robert ... Directors. "Bob is an ardent champion for innovation ... privilege to have him on Edwards, board as we pursue ... Edwards, chairman and CEO.  "Bob has provided a valuable perspective ...
Breaking Medicine Technology:Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 2Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 3Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 4Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 5Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 6Body Composition Analyzers Market Worth $1,425.7 Million by 2019 2Body Composition Analyzers Market Worth $1,425.7 Million by 2019 3Body Composition Analyzers Market Worth $1,425.7 Million by 2019 4
... 3, 2011 Silence Therapeutics plc (AIM: ... interference (RNAi) therapeutics company, announces that the United States ... notice of allowance on a patent application directed to ... proprietary small interfering RNA (siRNA) delivery systems. The allowable ...
... 3, 2011 Reportlinker.com announces ... report is available in its ... Orthopedic Devices Market Outlook to ... Surgery, Orthobiologics, Trauma Fixation and ...
Cached Medicine Technology:Silence Therapeutics Receives Notice of Allowance for New U.S. Patent Covering Novel Small Interfering RNA (siRNA) Delivery Technology 2Silence Therapeutics Receives Notice of Allowance for New U.S. Patent Covering Novel Small Interfering RNA (siRNA) Delivery Technology 3Silence Therapeutics Receives Notice of Allowance for New U.S. Patent Covering Novel Small Interfering RNA (siRNA) Delivery Technology 4China Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 2China Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 3China Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 4China Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 5China Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 6China Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 7China Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 8China Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 9China Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 10China Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 11China Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 12China Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 13China Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 14China Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 15China Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 16China Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 17China Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 18China Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 19China Orthopedic Devices Market Outlook to 2017 - Joint Reconstruction, Spinal Surgery, Orthobiologics, Trauma Fixation and Others 20
Post-Surgical compression garments...
... Albumin Cobalt Binding (ACB®) Test is a ... Albumin (IMA®) by measuring the cobalt binding ... sample. First identified in the early 1990s, ... in contact with ischemic tissue in the ...
... (ACB®) Test is a clinical chemistry assay ... measuring the cobalt binding capacity of albumin ... in the early 1990s, IMA is produced ... ischemic tissue in the heart. During ischemia, ...
... autoimmune testing feature single-well ANA screen and ... reflex tests including dsDNA, and 6 individual ... (La), Scl-70 and Jo-1. In addition, our ... of products for Cardiolipins (IgA, IgG, IgM), ...
Medicine Products: