Navigation Links
U-M scientists find new causes for neurodegeneration
Date:10/25/2007

ch.

Building on research from Meisler, a mouse geneticist, and Weisman, a yeast geneticist, the collaborators published a paper in Nature, July 5, 2007, showing that in mice, the FIG4 gene is required to maintain normal levels of the signaling lipid and to maintain a normal nervous system. Importantly, they found that human patients with a very minor defect in their FIG4 genes had serious neurological problems.

The signaling lipid PI(3,5)P2 (short for phosphatidylinositol 3,5-bisphosphate) is part of a communication cascade that senses changes outside the cell and promotes actions inside the cell to accommodate to the changes.

Weisman's team found that mice missing the VAC14 gene, which encodes a regulator of PI(3,5)P2 levels, suffer massive neurodegeneration that looks nearly identical to the neurodegeneration seen in the FIG4 mutant mice. In both cases the levels of PI(3,5)P2 are one half of the normal levels. The fact that both mice have half the normal levels of the lipid and also have the same neurodegenerative problems provides evidence that there is a direct link between the lipid and neuronal health.

The new findings indicate that when Vac14 is removed, the cell bodies of many of the neurons appear to be empty spaces and the brain takes on a spongiform appearance.


'/>"/>

Contact: Robin Stephenson
rbs@umich.edu
734-615-9390
University of Michigan
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Nobel Prize for Medicine shared by Three scientists
2. Scientists plan human cloning clinic in the United States
3. Scientists crack mechanism of Leptin-Obesity Hormone
4. Scientists use plant hormones to fight cancer
5. American scientists alter gene makeup of babies
6. Expose on eating disorders!! Scientists trace “brain’s eating control center pathway”
7. Scientists found ancient Human Germ Killer
8. Scientists locate key hormone involved in appetite control
9. Scientists open the book of life
10. Electronic nose by Italian scientists
11. Scientists review SARS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/4/2015)... Follow us on LinkedIn – Breast pumps ... the breast of a lactating mother through the suction mechanism, ... the baby. Breast pumps are used when direct feeding is ... mother being away from a child for a longer time ... are also used to stimulate lactation and relieve engorgement of ...
(Date:3/4/2015)... Baltimore, Maryland (PRWEB) March 04, 2015 ... from broccoli, announced today the rebrand of its SGS™ ... deliver at least 13 percent glucoraphanin, which is the ... the market. Brassica’s rebranding initiative includes a new truebroc ... reflect the new look and brand name. , ...
(Date:3/4/2015)... Whatever one's feelings about the Fifty Shades ... talking. Everyone from hard-core fans of the trilogy, to people ... who hasn't read even one of the books, is putting ... Korbabicz, the general manager of HUSH, a leading retailer of ... a very good thing. , "When the books came out ...
(Date:3/4/2015)... The defibrillators report provides insights into the growth trends ... global market is expected to grow at a CAGR ... 2019. It expects the emerging markets to provide crucial ... players in the market. , According to the report, ... the highest CAGR during the next five years. The ...
(Date:3/4/2015)... proud to announce a new probiotic lozenge which, in addition ... , Many health experts agree that introducing healthy bacteria ... can cause unwanted infections. While most people produce some level ... help of a probiotic to elevate the most crucial “good” ... S. salivarius M18 & K12 strains of “good” bacteria, the ...
Breaking Medicine News(10 mins):Health News:Increase in the Number of Nursing Mothers in the Workplace Spurs the Breast Pumps Market, According to a New Report by Global Industry Analysts, Inc. 2Health News:Increase in the Number of Nursing Mothers in the Workplace Spurs the Breast Pumps Market, According to a New Report by Global Industry Analysts, Inc. 3Health News:Brassica Protection Products Rebrands its SGS™ Brand of Glucoraphanin to truebroc™ 2Health News:Fifty Shades of Grey™ Has Canadians Talking About Sex. 2Health News:Defibrillators Market worth $12.9 Billion by 2019 with Rise in Aging Population - New Research Report by MarketsandMarkets 2Health News:Defibrillators Market worth $12.9 Billion by 2019 with Rise in Aging Population - New Research Report by MarketsandMarkets 3Health News:TheraBreath introduces a new line of probiotic lozenges that strengthen the body’s ability to fight germs 2
... Texas, Dec. 4 MiddleBrook,Pharmaceuticals, Inc. (Nasdaq: ... opened its,administrative and sales office in Westlake, Texas. ... certain personnel and functions, including,MiddleBrook,s research and development ... facility is expected to house up to 60 ...
... 4 Universal Health,Realty Income Trust (NYSE: UHT ... with the appointment of Marc D. Miller, Senior Vice,President of ... UHT,more than 13 years of experience in healthcare leadership roles. ... of the Acute Care Division,since 2007 and prior to that, ...
... Unites Leaders of Virginia, Maryland and D.C. AIDS Offices , ... Nationally, Washington, D.C. ranks first in AIDS cases. Of ... American. In an effort to increase awareness of this ... at the George Washington University brought together the ...
... NAPERVILLE, Ill., Dec. 4 NAMC members can gain access ... nationally-recognized speakers and opportunities for interaction via computer. The ... Finding and Communicating With Your Online Audience , ... audiences live? Once you,ve found them, do you know how ...
... ethics online forum , , ... Compliance and Ethics (SCCE) and the Health Care Compliance ... Social Network sites available to all compliance and ethics ... the social network sites and participate in the online ...
... Asks, "Is Mercury a Common Factor?" , ... announced last week call into question the safety of the ... administering multiple vaccines concurrently. , , ... published last week in PLOS One by investigators from the ...
Cached Medicine News:Health News:Middlebrook Pharmaceuticals Opens Administrative and Sales Office in Westlake, Texas 2Health News:Middlebrook Pharmaceuticals Opens Administrative and Sales Office in Westlake, Texas 3Health News:Middlebrook Pharmaceuticals Opens Administrative and Sales Office in Westlake, Texas 4Health News:Southern AIDS Living Quilt Raises Awareness in Washington, D.C. 2Health News:Southern AIDS Living Quilt Raises Awareness in Washington, D.C. 3Health News:New NAMC Member Service! Complimentary Webinars for NAMC Members - On Topics You Need to Know! Sign Up Today for This New and Exciting Educational Program! 2Health News:SCCE and HCCA Social Network Now Open to All Compliance and Ethics Professionals 2Health News:SCCE and HCCA Social Network Now Open to All Compliance and Ethics Professionals 3Health News:Researchers & Department of Defense Question Multiple Vaccine Administration 2
(Date:3/4/2015)... 4, 2015   InspireMD, Inc.  ("InspireMD" or the ... systems ("EPS"), today announced that it has entered into ... million shares of common stock and warrants to purchase ... in a public offering.  The common stock will be ... share, and each purchaser will receive a warrant to ...
(Date:3/4/2015)... Israël, 4 mars 2015 /PRNewswire/ ... (« RedHill » ou la « Société »), une ... sur les spécialités pharmaceutiques administrés ... stade clinique avancé pour les ... notamment les cancers gastro-intestinaux, a ...
(Date:3/4/2015)... -- ANI Pharmaceuticals, Inc. (NASDAQ: ANIP ) announced today ... at the Ritz-Carlton at Laguna Niguel, California ... Arthur S. Przybyl , President and CEO, will give the ... ANI,s website at www.anipharmaceuticals.com . Mr. Przybyl,s presentation will ... available through the link through June 7, 2015. ...
Breaking Medicine Technology:InspireMD Announces Public Offering for Approximately $13.5 Million 2InspireMD Announces Public Offering for Approximately $13.5 Million 3InspireMD Announces Public Offering for Approximately $13.5 Million 4RedHill Biopharma présentera à l'événement en ligne sur VirtualInvestorConferences.com le 5 mars 2015 2RedHill Biopharma présentera à l'événement en ligne sur VirtualInvestorConferences.com le 5 mars 2015 3RedHill Biopharma présentera à l'événement en ligne sur VirtualInvestorConferences.com le 5 mars 2015 4RedHill Biopharma présentera à l'événement en ligne sur VirtualInvestorConferences.com le 5 mars 2015 5ANI Pharmaceuticals To Present At 27th Annual ROTH Conference 2
... YORK, Jan. 12, 2011 NeoStem, Inc. (NYSE Amex: ... company with operations in the U.S. and China, today announced ... present on Wednesday, January 12, 2011 at the OneMedForum 2011 ... at 11:00 AM PST. Both events will be held in ...
... InstaCare Corp. (OTC Bulletin Board:  ISCR) a ... testing products for the chronically ill, a leading ... and a leading developer of revolutionary cell phone ... company,s Board of Directors has received the initial ...
Cached Medicine Technology:NeoStem to Present at Two Investor Conferences in San Francisco on Wednesday, January 12, 2011 2NeoStem to Present at Two Investor Conferences in San Francisco on Wednesday, January 12, 2011 3InstaCare Corp. Announces 2011 Genstrip Guidance Report Penned by William Walling, CFA 2
... The Vision5L Digital ... 5- or 7-lead, ... a signal preview,screen. ... using a compact,flash ...
The Atria 6100 delivers the highest level of clinical performance while incorporating cutting-edge technology to streamline clinic workflow. It offers timely, high-quality, and accurate ECG results c...
... CSV-1000CVA test face is used to evaluate both ... levels (high, 25% and 12.5%) of LogMAR acuity ... face as well as the two spatial frequencies ... most widely used for cataract documentation because eye ...
... is used widely for screening refractive surgery ... from 20/10 to 20/100 and one row ... ,The patient can be easily screened in ... contrast sensitivity. If a contrast sensitivity deficit ...
Medicine Products: