Navigation Links
U-M scientists develop tool to probe role of oxidative stress in aging, disease
Date:2/15/2008

ANN ARBOR, Mich.---Oxygen, although essential for human life, can turn into an aggressive chemical that is outright toxic to important molecules inside our cells. This "oxidative stress" is associated with many diseases, such as Alzheimer's, heart disease and cancer, and has been suggested to be the culprit underlying aging.

In an article published online Feb. 14 in the journal Proceedings of the National Academy of Sciences (PNAS), University of Michigan researchers led by associate professor Ursula Jakob report on a new method that allows them to observe how oxidative stress affects the major building blocks of a cell, the proteins. The new technique, called OxICAT, makes it possible to quantify the oxidation state of thousands of different proteins in a single experiment.

Jakob was intrigued to find many proteins that are not permanently damaged by reactive oxygen species but actually use amino acids known as cysteines to sense oxidative stress.

"In my lab, we have been working for a long time on proteins that use cysteine as a reactive oxygen sensor," Jakob said. "With this new technique, we discovered scores of novel proteins that are sensitive towards reactive oxygen species. Interestingly, we found that many of the proteins that we identified are important for the cells to survive oxidative stress conditions." Jakob and her team now are using this powerful technique to gain fundamental insights into the molecular mechanism of aging and the role that oxidative stress plays in this process.

"Because oxidative stress plays such a prominent role in all these diseases, we want to understand why some cells and organisms can cope with the dangers of oxidative stress, while others die," said Lars Leichert, a postdoctoral research fellow in Jakob's lab and first author of the study. Such insights might lead to the development of more powerful and effective anti-oxidant strategies.


'/>"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
Source:Eurekalert

Page: 1

Related medicine news :

1. Scientists Show Stem Cells Dont Cause Cancer
2. Microbial cheaters help scientists ID social genes
3. Scientists solve structure of gene regulator that plays key role in cancer
4. VEGF Neutralization Can Damage Brain Vessels, Say Schepens Eye Research Institute Scientists
5. VEGF neutralization can damage brain vessels, say Schepens Eye Research Institute scientists
6. Precious Time - Scientists discover how long heart failure patients can expect to live
7. UCLA stem cell scientists reprogram human skin cells into embryonic stem cells
8. Scientists Reprogram Human Skin Cells Into Embryonic Stem Cells
9. Scientists from Europe, Israel and the US develop robotic rats to aid in rescue missions
10. Childrens Hospital scientists identify possible target for prevention and treatment of pneumonia
11. NIAID scientists identify new cellular receptor for HIV
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the ... Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , “We ... new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice ...
(Date:6/25/2016)... ... ... Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and Mental ... exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took place ... BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive an ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set ... drug or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, ... traumatic event. , Trauma sufferers tend to feel a range of emotions, from depression, ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association ... it will receive two significant new grants to support its work to advance ... 25th anniversary by recognizing patients, medical professionals and scientists for their work in ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA ... the Road To Recovery® program to drive cancer patients to and from their cancer ... ensure the highest quality of life and ongoing independence. Getting to and from ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 26, 2016 One of ... has announced the formation of a new biotechnology company, Noxopharm Limited ... $6m in an IPO and to list on the ASX. ... candidate, NOX66, ready to enter a Phase 1 clinical study later ... designed to address one of the biggest problems facing cancer patients ...
(Date:6/26/2016)... -- Jazz Pharmaceuticals plc (Nasdaq: JAZZ ) ... Improvements Act of 1976, as amended ("HSR"), with respect ... Nasdaq: CPXX ) expired effective June 24, ... As previously announced on May 31, 2016, Jazz Pharmaceuticals ... which Jazz Pharmaceuticals has commenced a tender offer for ...
(Date:6/26/2016)... -- VMS Rehab Systems, Inc. ( www.vmsrehabsystemsinc.com ) reported today ... to build a strong and stable market for trading ... the OTC Markets-pink current trading platform. Explains ... seeing an anomaly in market trading activities that may ... Company, but shareholders and market players as well. I ...
Breaking Medicine Technology: