Navigation Links
U-M scientists develop tool to probe role of oxidative stress in aging, disease
Date:2/15/2008

ANN ARBOR, Mich.---Oxygen, although essential for human life, can turn into an aggressive chemical that is outright toxic to important molecules inside our cells. This "oxidative stress" is associated with many diseases, such as Alzheimer's, heart disease and cancer, and has been suggested to be the culprit underlying aging.

In an article published online Feb. 14 in the journal Proceedings of the National Academy of Sciences (PNAS), University of Michigan researchers led by associate professor Ursula Jakob report on a new method that allows them to observe how oxidative stress affects the major building blocks of a cell, the proteins. The new technique, called OxICAT, makes it possible to quantify the oxidation state of thousands of different proteins in a single experiment.

Jakob was intrigued to find many proteins that are not permanently damaged by reactive oxygen species but actually use amino acids known as cysteines to sense oxidative stress.

"In my lab, we have been working for a long time on proteins that use cysteine as a reactive oxygen sensor," Jakob said. "With this new technique, we discovered scores of novel proteins that are sensitive towards reactive oxygen species. Interestingly, we found that many of the proteins that we identified are important for the cells to survive oxidative stress conditions." Jakob and her team now are using this powerful technique to gain fundamental insights into the molecular mechanism of aging and the role that oxidative stress plays in this process.

"Because oxidative stress plays such a prominent role in all these diseases, we want to understand why some cells and organisms can cope with the dangers of oxidative stress, while others die," said Lars Leichert, a postdoctoral research fellow in Jakob's lab and first author of the study. Such insights might lead to the development of more powerful and effective anti-oxidant strategies.


'/>"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
Source:Eurekalert

Page: 1

Related medicine news :

1. Scientists Show Stem Cells Dont Cause Cancer
2. Microbial cheaters help scientists ID social genes
3. Scientists solve structure of gene regulator that plays key role in cancer
4. VEGF Neutralization Can Damage Brain Vessels, Say Schepens Eye Research Institute Scientists
5. VEGF neutralization can damage brain vessels, say Schepens Eye Research Institute scientists
6. Precious Time - Scientists discover how long heart failure patients can expect to live
7. UCLA stem cell scientists reprogram human skin cells into embryonic stem cells
8. Scientists Reprogram Human Skin Cells Into Embryonic Stem Cells
9. Scientists from Europe, Israel and the US develop robotic rats to aid in rescue missions
10. Childrens Hospital scientists identify possible target for prevention and treatment of pneumonia
11. NIAID scientists identify new cellular receptor for HIV
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... 28, the Center for BrainHealth will bring together ... pressing brain-related challenges at its inaugural Brain Health ... Regeneration." Featured speakers will include Dr. Sandra Bond ... for BrainHealth, U.S. Senator Chuck Grassley (R-IA), U.S. ... Assistant Secretary for Policy and Early Learning, U.S. ...
(Date:4/24/2014)... terminology, and the relevance of palliation in advanced ... randomized controlled trials (RCTs). This is the result ... Quality and Efficiency in Health Care (IQWiG), which ... Together with external experts, IQWiG analysed studies on ... malignant melanoma, and pancreatic cancer. For this purpose, ...
(Date:4/24/2014)... is better to give than to receive at least ... study suggests. , The study found that 15- and 16-year-olds ... money to family members, are less likely to become depressed ... or keeping the money for themselves. , The researchers detail ... of Sciences . , The study focused on the ventral ...
(Date:4/24/2014)... Oregon State University researcher has found a relationship between ... of autism spectrum disorder in very young children. ... to show a direct relationship between motor skills and ... motor skills should be included in treatment plans for ... professor in OSU,s College of Public Health and Human ...
(Date:4/24/2014)... scientist at the University of York reveals that a ... of the nervous system may also play a pivotal ... research team, led by Dr Will Brackenbury, a Medical ... York, has studied how voltage-gated sodium channels assist in ... in the membranes of excitable cells, such as neurons, ...
Breaking Medicine News(10 mins):Health News:Inaugural Brain Health Summit focuses on brain resilience and regeneration 2Health News:Palliation is rarely a topic in studies on advanced cancer 2Health News:Palliation is rarely a topic in studies on advanced cancer 3Health News:Study: Altruistic adolescents less likely to become depressed 2Health News:Motor skill deficiencies linked to autism severity in new research 2Health News:Breast cancer replicates brain development process 2
... LAKE FOREST, Ill. and MINNEAPOLIS , ... Fitness Corporation (NYSE AMEX: FIT ) today announced that ... the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act in ...   http://www.newscom.com/cgi-bin/prnh/20090122/CG61641LOGO ) , On January 21, 2010 , ...
... WASHINGTON , Feb. 5 In response ... today, the American Veterinary Medical Association (AVMA) is reaffirming its ... help maintain and improve the health of U.S. livestock. , ... creating a new strategy for animal disease traceability. This comes ...
... ... San Francisco,s famed PIER 39 docks, was successfully rescued, rehabilitated and released back to the ... assembled at Rodeo Beach in the Marin Headlands, Sausalito, CA to watch as "Abagnale" made ... ...
... focus of new laws, online testing and Super Bowl plug ... improve treatment of concussions in youth sports are making headway ... in scholastic sports will get big play Sunday at Super ... can help athletic trainers and doctors determine when it,s safe ...
... LOS ANGELES , Feb. 5 Food 4 ... to support children,s hospitals in the communities its stores serve in ... Chicago area. In addition, the supermarket chain,s Foods Co ... California . , Customers and team members can support their ...
... Finding may further understanding of common diseases, researchers say , ... map of areas of the human genome that control which ... a finding that may advance understanding of the genetic ... the human genome is uncharted territory -- entire stretches of ...
Cached Medicine News:Health News:Trustmark and HealthFitness Announce Early Termination of Hart-Scott-Rodino Waiting Period 2Health News:Trustmark and HealthFitness Announce Early Termination of Hart-Scott-Rodino Waiting Period 3Health News:Trustmark and HealthFitness Announce Early Termination of Hart-Scott-Rodino Waiting Period 4Health News:AVMA Calls for Stronger Animal Disease Traceability System 2Health News:Entangled in Fishing Line then Rescued by The Marine Mammal Center - a Sea Lion Goes Back to the Ocean 2Health News:Entangled in Fishing Line then Rescued by The Marine Mammal Center - a Sea Lion Goes Back to the Ocean 3Health News:Entangled in Fishing Line then Rescued by The Marine Mammal Center - a Sea Lion Goes Back to the Ocean 4Health News:Concussion Awareness for Young Athletes Gets Big Play 2Health News:Food 4 Less Charitable Campaign to Benefit Children's Hospitals 2
(Date:1/15/2014)... 15, 2014  Zafgen, Inc., a leading biopharmaceutical company ... obese patients, today announced initial results from its ... of methionine aminopeptidase 2 (MetAP2), in patients with ... obesity.  These results showed improvements in body weight, ...
(Date:1/14/2014)... , Jan. 14, 2014 HeartWare International, Inc ... of less invasive, miniaturized circulatory support technologies that are ... that it expects revenues for the fourth quarter of ... 2013 revenues to approximately $208 million. "Our ...
(Date:1/14/2014)... North America,s leading business partnering event ... 30 th edition of its annual conference at the ... 21-24. (Logo: http://photos.prnewswire.com/prnh/20131028/NY05330LOGO-a ) ... specialty chemical companies will take part in the conference, which ...
Breaking Medicine Technology:Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 2Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 4HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 2HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 3HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 4Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2
... Global public relations leader Porter Novelli today announced that ... Prix Galien USA Awards, which recognize excellence in biopharmaceutical ... condition. Porter Novelli will be responsible for raising awareness ... of submissions. The Prix Galien is ...
...   - Jayex , ... the Trust to , Instantly Review ... , Delivery of High-Quality Patient,Centred Care ... technology specialist, http://www.jaxex.com today,announces that United Lincolnshire NHS Trust (ULHT) has,selected ...
Cached Medicine Technology:Porter Novelli Named Agency of Record for Prix Galien USA Awards 2United Lincolnshire Hospitals NHS Trust Selects Jayex QI Interactive Patient Survey and Information Management Kiosk 2
Mayfield Disposable Adult (plastic) Skull Pins are designed for rigid skeletal fixation....
... borescopes are rigid endoscopes for general applications and ... The diameters of borescopes, i.e. rigid endoscopes, range ... directions from 0 up to a 120 retrospection, ... and wide angle view. Endoscopes with working lengths ...
Long system ventriculoscope for stereotactic frames....
... a new biological material produced ... collagen implant, lyoplant can absorb ... replacing implant material with the ... structure minimizes suture channels, resulting ...
Medicine Products: