Navigation Links
U-M researcher's idea jells into potential new disease-detection method
Date:3/22/2009

ANN ARBOR, Mich.---Relying on principles similar to those that cause Jell-O to congeal into that familiar, wiggly treat, University of Michigan researchers are devising a new method of detecting nitric oxide in exhaled breath.

Because elevated concentrations of nitric oxide in breath are a telltale sign of many diseases, including lung cancer and tuberculosis, this development could prove useful in diagnosing illness and monitoring the effects of treatment.

Assistant professor of chemistry Anne McNeil and graduate student Jing Chen will discuss the work at the spring meeting of the American Chemical Society in Salt Lake City, Utah.

McNeil and Chen work with molecular gels, which differ from Jell-O in being made up of small molecules, rather than proteins. But there are also key similarities, McNeil said.

"In both Jell-O and molecular gels, you can use heat to dissolve the material, which then precipitates out into a gel structure. This gel structure is basically a fibrous network that entraps solvent in little pockets," she said.

The researchers wanted to design a material made up of molecules that would organize themselves into a gel when prompted by particular cue ---in this case, the presence of nitric oxide and oxygen. Other research groups have achieved similar feats with materials whose solubility changes when exposed to triggers (for example, a change in pH). But McNeil had the idea of promoting the process, known as stimuli-induced gelation, by changing the stackability of the molecules that make up the material.

"We took the approach of designing a molecule that has a shape that won't pack together with other, identical molecules very well, but will change into a more stackable shape on exposure to nitric oxide," McNeil said. When the molecules stack together, gelation occurs.

Because it's easy to see when the material stops flowing and turns into a gel, this method of nitric oxide detection is simpler and less subject to interpretation than other detection methods such as colorimetry and spectroscopy.

"I like the simplicity of not needing an instrument and just being able to flip the sample vial over and see if a gel has formed," McNeil said. At this point, the new technique isn't sensitive enough for clinical use, but McNeil and Chen are working to improve its sensitivity. They're also extending the approach to design materials that would use stimuli-induced gelation to detect hazardous materials, such as explosives.


'/>"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
Source:Eurekalert

Related medicine news :

1. Focus on treating malnutrition in cancer patients, researchers say
2. Researchers Suspect Genetic Link to COPD
3. Syracuse University researchers build a new surface material that resists biofilm growth
4. Researchers Use Gene to End High Blood Sugar in Mice
5. Penn researchers identify new protein important in breast cancer genes role in DNA repair
6. Fish health claims may cause more environmental harm than good: UBC-St. Michaels researchers
7. Researchers clone key sperm-binding proteins
8. Researchers find sustained improvement in health in Experience Corps tutors over 55
9. Researchers develop DNA patch for canine form of muscular dystrophy
10. University of Pennsylvania researchers find that the unexpected is a key to human learning
11. Researchers discover ways of integrating treatment of traumatized Tibetan refugee monks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... Southlake, Texas (PRWEB) , ... April 29, 2016 , ... ... and neck pain, is proud to announce one of their physicians has been invited ... Osteopathic Family Physicians (Texas ACOFP) Family Practice Review conference on April 30, 2016. ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... student team BioCellection won the $30,000 Perlman Grand Prize of the 2016 Wharton ... Undergraduate Award, the Michelson People‚Äôs Choice Award, and the Committee Award for Most ...
(Date:4/29/2016)... ... April 29, 2016 , ... Mobility Designed is redefining mobility with ... armpits, the M+D Crutch evenly distributes body weight from the elbow to the forearm. ... using the crutches than with other crutches. , Co-founders Max and Liliana Younger were ...
(Date:4/29/2016)... ... April 29, 2016 , ... World Patent Marketing ... an exercise invention which aids in proper muscle development. , "The Gym & ... Creative Director of World Patent Marketing. "Globalization has threatened the future growth of ...
(Date:4/29/2016)... ... April 29, 2016 , ... The Gluten-Free Certification Program ... to announce the launch of the GFCP Scoop in response to ... purpose of the GFCP Scoop site is to keep the gluten-free ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... , April 27, 2016  Bayer Animal Health ... senior from the University of Florida College of ... Bayer Excellence in Communication Award (BECA). Brittany was ... were awarded a total of $70,000 in scholarship ... four years, Bayer has provided a total of ...
(Date:4/27/2016)... SAN FRANCISCO , April 27, 2016 /PRNewswire/ ... to reach over USD 2.14 billion by 2022, ... Research, Inc.       (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ... key technological advancement affecting the efficiency and accuracy ... hence, the persistent demand for novel urinalysis instruments ...
(Date:4/26/2016)... , April 26, 2016 Hill-Rom Holdings, Inc. ... a management presentation at the Deutsche Bank 41 st ... 2:50 p.m. EDT. You are invited to listen ... http://ir.hill-rom.com/events.cfm or access it directly at http://edge.media-server.com/m/p/mr4uxgas . ... hour after conclusion of the live event and accessible at ...
Breaking Medicine Technology: