Navigation Links
U-M researchers find protein that fuels repair of treatment-resistant cancer cells
Date:7/31/2014

ANN ARBORImagine you're fighting for your life but no matter how hard you hit, your opponent won't go down.

The same can be said of highly treatment-resistant cancers, such as head and neck cancer, where during radiation and chemotherapy some cancer cells repair themselves, survive and thrive. Head and neck cancer is the sixth most common cancer in the world, but the late detection and treatment resistance result in a high mortality rate.

Now, University of Michigan researchers have found that a particular proteinTRIP13encourages those cancer cells to repair themselves. And they have identified an existing chemical that blocks this mechanism for cell repair.

"This is a very significant advance, because identifying the function of the protein that fuels the repair of cancer cells and having an existing chemical that blocks the process, could speed the process of moving to clinical trials," said principal investigator Nisha D'Silva, U-M professor of dentistry and associate professor of pathology.

Typically, if scientists discover a promising drug therapy target, it takes years to develop drug compounds from scratch and move these into clinical trials.

If cell DNA is damaged and the cell cannot repair the damage, the cell dies. In head and neck cancers, D'Silva and colleagues showed that cancer cells that overexpress TRIP13 were able to repair their DNA enough to survive and continue to grow as cancer.

"Targeting this repair mechanism with specific drugs could increase effectiveness of treatment and improve survival of cancer patients," D'Silva said. "And given the overexpression of TRIP13 in several treatment-resistant cancers, this strategy will likely be important for multiple cancers."


'/>"/>

Contact: Laura Bailey
baileylm@umich.edu
734-647-1848
University of Michigan
Source:Eurekalert

Page: 1

Related medicine news :

1. Neuro researchers advocate for a shift in thinking for stroke rehabilitation
2. Penn researchers: Naltrexone may diminish impulse control disorders in Parkinsons disease patients
3. Brazilian researchers identify RNA that regulates cell death
4. Researchers take steps toward development of a vaccine against tick-transmitted disease
5. UTSW cancer researchers identify irreversible inhibitor for KRAS gene mutation
6. Researchers identify potential biomarker for AD
7. BU researchers discover that Klotho is neuroprotective against Alzheimers disease
8. Researchers discover new way to determine cancer risk of chemicals
9. A world first: Researchers identify a treatment that prevents tumor metastasis
10. Researchers unlock the protein puzzle
11. Communication about female condom vital to young adults, UT Arlington researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... , ... Warren L. Smith M.D. , There is a new tool in ... since the beginning of recorded medical history, and in spite of all the antibiotics ... a matter of inconvenience; bladder infections cost us billions of dollars annually in lost ...
(Date:5/4/2016)... ... May 04, 2016 , ... DESCO Medical Service, ... Sterilizer, an equipment sterilization service and sales company located in Pennsylvania. The terms ... research-related equipment and asset management services to the medical and academic research industries. ...
(Date:5/4/2016)... (PRWEB) , ... May 04, 2016 , ... ... provider, certified that their Vasont Universal Integrator (VUI) extension supports the latest release ... release of Adobe FrameMaker 2015 interlace the process of creating, editing and storing ...
(Date:5/3/2016)... ... ... The National Association of Professional Women (NAPW) honors Barbara ... She is recognized with this prestigious distinction for leadership in business. NAPW is the ... over 200 operating Local Chapters. , “I’m pleased to welcome Barbara into this exceptional ...
(Date:5/3/2016)... ... May 03, 2016 , ... Today at its Annual Technology ... D. Pulido, R.Ph., Co-Founder of NCPDP and member of the NCPDP Foundation Board ... IT Specialist, Office of the National Coordinator for Health Information Technology (ONC). NCPDP’s ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... , May 4, 2016 ... 154 pages, profiling 09 key companies and supported ... professional and in-depth study on the current state ... overview of the industry including definitions, classifications, applications ... analysis is provided for the international market including ...
(Date:5/3/2016)... Research and Markets has announced the addition ... Outlook 2020" report to their offering. ... has improved significantly in past years due to which ... years. Many cancer drugs have been developed by utilization ... expected to be developed with its help. They are ...
(Date:5/3/2016)... -- As a teenager, an active and athletic Randy ... heart. He continued enjoying sports and recreation throughout his ... was giving out and he was a few hours ... Mesa, Arizona resident received a ... transplant, the SynCardia TAH-t is the only approved device ...
Breaking Medicine Technology: