Navigation Links
U-M researchers discover therapeutic target that could help patients with pulmonary fibrosis

ANN ARBOR, Mich. A diagnosis of Idiopathic Pulmonary Fibrosis is not much better than a death sentence: there is no treatment and the survival rate is less than three years.

But researchers at the University of Michigan have discovered that targeting of a novel gene utilizing genetic and pharmacologic strategies was successful in treating pulmonary fibrosis in mice and will be developed for future testing in humans.

The treatments attack an oxidant-generating enzyme, NOX4, that researchers discovered is involved in the fibrotic process which involves scar-like tissue formation in an organ such as the lung. The researchers' findings will be published in the September issue of the journal Nature Medicine.

"We've identified the target. We know the enemy now," said Subramaniam Pennathur, M.D., assistant professor of internal medicine/nephrology. "This is the first study that shows pulmonary fibrosis is driven by this NOX4 enzyme.

"But what's really significant is this discovery may have relevance to fibrosis in other organ systems, not just the lung."

So those suffering from common cardiac or kidney diseases, which often involve fibrosis, also may benefit from treatments stemming from this research, Pennathur said.

Pennathur said continued support from the National Institutes of Health will eventually allow researchers to take the treatment to human studies. The University of Michigan also has filed for patent protection and is currently looking for a licensing partner to help bring the technology to market.

The discovery was made in the University of Michigan lab of Victor J. Thannickal, M.D. He was assisted by Louise Hecker, Ph.D., a post-doctoral research fellow.

Thannickal said the study points to a very viable treatment strategy for idiopathic pulmonary fibrosis, and researchers saw success both in mouse models of lung fibrosis and in fibrogenic cells isolated from lungs of patients with Idiopathic Pulmonary Fibrosis.

"It remains to be seen if fibrosis is reversible," he said. "But therapeutic targeting of this pathway this may allow us to halt the progression of fibrosis and preserve lung function."

The lung disease often affects older people, Thannickal said, and its cause is generally unknown. It is possible that cumulative injuries like exposure to environmental toxins and pollutants in genetically susceptible individuals could contribute to causing fibrosis.

There is a gradual scarring of the lung, thickening and contracting the organ until it loses its ability to exchange oxygen with blood, Hecker said. Patients experience extreme fatigue, rapid weight loss, chronic cough and shortness of breath.

There are five million people worldwide that are affected by this disease, according to the Pulmonary Fibrosis Foundation. In the United States there are over 100,000 patients with Pulmonary Fibrosis.

When U-M researchers induced the fibrotic process in the mice, they discovered that the NOX4 enzyme was elevated. By knocking down that enzyme at the genetic level or inhibiting its activity, the fibrosis was stopped, Hecker said.

"So we may be able to halt lung scarring even after the injury has occurred and fibrosis is set in motion," she said. "This research provides proof of concept that we can target this pathway for therapeutic benefit, which could potentially be used in humans."


Contact: Mary Masson
University of Michigan Health System

Related medicine news :

1. UCSF Researchers Identify Two Key Pathways in Adaptive Response
2. Alcohol advertising reaching too many teens on cable TV, researchers say
3. NIH researchers identify key factor that stimulates brain cancer cells to spread
4. Pitt researchers harness carbon nanomaterials for drug delivery systems, oxygen sensors
5. Microsoft Rogue Internet Pharmacy Problem Fixed? Not So Fast, Say Researchers
6. Researchers identify potential new avenue to attack cancer
7. Researchers find alcoholics display abnormal brain activity when processing facial expressions
8. UT Southwestern researchers launch study into search-and-destroy antigen for deadly skin cancer
9. Researchers Produce First Nationwide Study of Homeless in ERs
10. Yerkes researchers propose ambitious new strategies for AIDS vaccine research
11. Researchers Identify New Method to Selectively Kill Metastatic Melanoma Cells
Post Your Comments:
Related Image:
U-M researchers discover therapeutic target that could help patients with pulmonary fibrosis
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency ... named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. ... Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van ... Wellness at Work award to iHire in recognition of their exemplary accomplishments in worksite ... 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Those who have ... these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as ... Michigan, has released tools for healthy coping following a traumatic event. , Trauma sufferers ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association ... it will receive two significant new grants to support its work to advance ... 25th anniversary by recognizing patients, medical professionals and scientists for their work in ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...  Arkis BioSciences, a leading innovator in the ... cerebrospinal fluid treatments, today announced it has secured ... led by Innova Memphis, followed by Angel Capital ... Arkis, new financing will accelerate the commercialization of ... of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... Research and Markets has announced ... Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality ... - Global Forecast to 2021" report to their ... global pharmaceutical excipients market is projected to reach USD ... in the forecast period 2016 to 2021. ...
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on the ... announced that patient enrollment in its ongoing randomized ... has exceeded 50% of its 24-patient target. Capricor ... the third quarter of 2016, and to report ...
Breaking Medicine Technology: