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U-M researchers advocate national strategic approach to therapeutic cancer vaccines
Date:6/8/2011

ANN ARBOR, Mich. Vaccines that save lives by preventing disease have been around for centuries. Now, new vaccines that treat cancer are being developed, but how they will be combined with existing treatments is not clear.

Researchers at the University of Michigan Health System recommend that a national strategy be developed for bringing therapeutic cancer vaccines to patient care, so that cancers with less effective treatment options are priority targets.

"Vaccines that prevent disease have profoundly changed the lives of billions of people around the world," says Matthew M. Davis, M.D., MAPP, associate professor of pediatrics and internal medicine at the University of Michigan Medical School. "A national strategy for therapeutic cancer vaccines would help emphasize development and regulatory approval for vaccines targeting cancers that currently do not have other good therapeutic options."

Davis and co-author Elias J. Dayoub, a student at the U-M Medical School, published a commentary in the June 8 theme issue on cancer of the Journal of the American Medical Association.

When germs such as viruses or bacteria enter the body, the human immune system recognizes those germs as something abnormal and attacks them. Preventive vaccines use this natural response to prime the body's immune system so it can respond to bacteria such as pertussis (the cause of whooping cough) or viruses such as polio and measles.

With cancer cells, however, it is hard for the immune system to detect the "invaders," since they are the human body's own cells gone bad. Therapeutic cancer vaccines can enable the immune system to recognize undetected harmful cells and generate a response to fight back.

Lung cancer, pancreatic cancer and types of leukemia's all have lower survival rates than many other cancers because they respond poorly to currently available chemotherapy, radiation and surgery.

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Contact: Imran Hyder
imranh@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

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