Navigation Links
U-M researchers ID promising new cancer drug
Date:3/3/2008

ared to cause no toxicity to animals.

Many traditional cancer drugs also activate p53 but they do so by causing DNA damage. They kill not only tumor cells but also normal cells, thus having severe side effects. MI-219 is unique in that it is designed to activate p53 without causing DNA damage, specifically killing tumor cells. Indeed, MI-219 is highly effective in inhibiting tumor growth, and even inducing tumor regression, but it has caused no toxicity to animals at efficacious doses, says Wang, professor of internal medicine and pharmacology at the U-M Medical School and professor of medicinal chemistry at the U-M College of Pharmacy.

In addition to its effectiveness at killing cancer cells without toxic side effects, MI-219 can be developed as a pill that patients could take orally, rather than the traditional chemotherapy drugs that must be given intravenously at a hospital or cancer center.

While promising in preclinical studies, MI-219 needs to be evaluated in human clinical trials for its safety and efficacy for cancer treatment since it is a brand new drug, Wang cautions.

"We are very excited about the therapeutic potential of MI-219 for the treatment of many types of human cancer. Ascenta is committed to advancing MI-219, which we have designated AT-219, into human clinical trials," says study author Dajun Yang, M.D., Ph.D., senior vice president of research and a co-founder of Ascenta Therapeutics, a clinical-stage biopharmaceutical company that has licensed the technology related to MI-219 from U-M and plans to aggressively advance it into human clinical trials.


'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Researchers identify new genetic marker for breast cancer
2. Researchers describe mechanisms by which capon gene causes heart rhythm disturbances
3. Researchers develop new tool to predict who will use microbicides
4. USC researchers discover novel way to develop tumor vaccines
5. St. Jude Researchers Find Key Step in Programmed Cell Death
6. St. Jude researchers find key step in programmed cell death
7. Mayo Researchers Look for Explanation Behind High Incidence of Diabetes Among Asian Indians
8. Mayo researchers look for explanation behind high incidence of diabetes among Asian Indians
9. UT Southwestern researchers investigate predictors for sickle-cell-anemia complications
10. Researchers find possible target to treat deadly bloodstream infections
11. Rutgers researchers unlock mysteries of vitamin A metabolism during embryonic development
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
U-M researchers ID promising new cancer drug
(Date:7/31/2014)... 31, 2014 Web Programming Services, a ... certified internet marketing firm, has recently launched a new ... this service affordable for everyone, the company has announced ... , Web Programming Services has tailored the service ... brochure designing and likely expectations of the clients from ...
(Date:7/31/2014)... By Randy Dotinga ... -- The parasite that causes malaria is growing increasingly resistant ... new surveillance reports. But several new drugs are in development, ... new hope against this global killer. "Although there has ... the battle against malaria is far from won, and there ...
(Date:7/31/2014)... -- Recovery time after surgery may be reduced for ... to a new study. The study,s Irish researchers ... response, reducing the amount of time surgical patients, wounds ... true among people who tend to have healing complications. ... prescribed medications in the world. While they are typically ...
(Date:7/31/2014)... India (PRWEB) July 31, 2014 ... launched a new online reputation management service named ... as well as organizations get rid of Pissed ... the result of extensive research. ReputationChief.Com management assigned ... service for those who are struggling in their ...
(Date:7/31/2014)... New Delhi, India (PRWEB) July 31, 2014 ... Certified Internet Marketing Company, has introduced a new ... quite affordable.     , Ethane Web Technologies has designed ... the expectations of clients and Java Development service ... has given the company a confidence to promise ...
Breaking Medicine News(10 mins):Health News:Web Programming Services Introduces Affordable Brochure Designing Service 2Health News:Malaria Growing Resistant to Drugs Used to Fight It 2Health News:Malaria Growing Resistant to Drugs Used to Fight It 3Health News:Cholesterol Drugs May Speed Healing After Surgery 2Health News:ReputationChief.Com Announces a New Online Reputation Management Service 2Health News:Ethane Web Technologies Announces Java Development Service at Pocket Friendly Cost 2
... Biosciences LLC, a Boston-based company conceived in partnership ... today that Johnson & Johnson has joined the ... will have the opportunity to invest in the ... to fundamentally transform drug discovery and development and ...
... Limited (Nasdaq: WCRX ) announced today that ... close on Tuesday, January 27, 2009. In addition to ... Executive Officer and Paul Herendeen, Executive Vice President and ... audio webcast to discuss the 2009 Financial Guidance for ...
... Keystone Symposium - Obesity: Novel Aspects of the Regulation ... Genetics, Inc. (NYSE Alternext US: ILI) announced today that ... role genetics play in an individual,s ability to lose ... during tomorrow,s Keystone Symposium titled, "Obesity: Novel Aspects of ...
... Blood Bank is honored to announce that it has ... of Cellular Therapy ("FACT"). CORD:USE is a leading ... processing, storage and distribution of donated cord blood. ... more than 14,000 patients with over 70 life-threatening diseases ...
... DIEGO, Jan. 22 Aero Financial, Inc, a strategic ... that the company has been retained as a strategic ... distributor of natural health information and nutrition products.Pursuant to ... Finest(TM) in several facets of the company,s growth plans, ...
... for 11:00 a.m. ET POWAY, Calif., Jan. 22 ... provider of diagnostic imaging products and services that improve ... before the market opens on Thursday, February 5, 2009, ... December 31, 2008. A conference call is scheduled for ...
Cached Medicine News:Health News:Enlight Biosciences Expands to direct up to $52 Million to Transformational Enabling Technologies 2Health News:Enlight Biosciences Expands to direct up to $52 Million to Transformational Enabling Technologies 3Health News:Interleukin Genetics to Present Data Highlighting Link Between Inflammatory Gene Variations and Less Effective Weightloss 2Health News:Interleukin Genetics to Present Data Highlighting Link Between Inflammatory Gene Variations and Less Effective Weightloss 3Health News:CORD:USE Cord Blood Bank Receives Prestigious Accreditation from the Foundation for the Accreditation of Cellular Therapy 2Health News:Aero Financial Retained as Strategic Consultant by Only Natures Finest(TM) 2Health News:Digirad Corporation to Release Fourth Quarter and Year-End Financial Results on February 5, 2009 2
(Date:7/31/2014)... TRIANGLE PARK, N.C. , July 31, 2014 /PRNewswire/ ... Miami facilities to meet the clinical ... America .  The newly expanded facility will continue ... samples, consolidation of shipments to and from the region, ... In its newest location, Marken will combine its office ...
(Date:7/31/2014)... De Pfizer Clinical Research Unit (PCRU) heeft de lancering ... komaf voor medewerking aan klinisch onderzoek. De in ... twee onderzoekseenheden van Pfizer , een multinationaal farmaceutisch ... ontdekking en ontwikkeling van nieuwe medicijnen. Om onderzoeksprojecten te ... vrouwen van Japanse komaf – leeftijd 18 tot 55 ...
(Date:7/30/2014)... July 30, 2014  Cepheid (Nasdaq: ... contract with Premier will end on September 30, ... will be able to continue their relationship with ... MedAssets, Novation, and ROi, in addition to the ... Cepheid. "Cepheid has always recognized and ...
Breaking Medicine Technology:Marken Expands Miami Regional Logistics Center 2Gezonde vrijwilligers van Japanse komaf gezocht voor deelname aan Fase I klinisch onderzoek 2Cepheid Updates Status Of Premier Group Purchasing Organization (GPO) Agreement 2Cepheid Updates Status Of Premier Group Purchasing Organization (GPO) Agreement 3
... Feb. 9, 2011 Reportlinker.com announces that a ... catalogue: European Market for Dental ... http://www.reportlinker.com/p0377961/European-Market-for-Dental-Prosthetics-and-CAD/CAM-Devices-2011.html In 2010, ... crowns, bridges and dentures, were valued at over ...
... 2011 Protect Pharmaceutical Corporation (OTC Bulletin Board: ... of two patents and patents-applications to Grunenthal GmbH, a German ... discovery and research. The patent portfolio includes innovative pain drugs ... Ram Sesha, Protect,s Chief Operating Officer, said, "We are ...
Cached Medicine Technology:Reportlinker Adds European Market for Dental Prosthetics and CAD/CAM Devices 2011 2Protect Pharma Sells Patent Portfolio to Grunenthal GmbH 2
... a web-based application to securely access patient ... Users can login from virtually anywhere ... review stored patient studies. , ... images, and reports Quickly locates desired patient ...
... for Stainless Steel Kleener. SSK-80 is our ... stain remover for ultra-sonic cleaners. , ,Used ... your instruments by removing and inhibiting rust, ... points, box joints and moving instrument parts ...
... the ready-to-use, pre-cleaning enzymatic foam for use ... ,Hemaway Enzymatic Foam sprays on surgical instruments ... for use in the O.R. or when ... head start with Hemaway Enzymatic Foam can ...
... The Shandon Cytospin has been ... 35 years. More than 15,000 ... reliable instrument. It provides economical ... matrix, especially hypocellular fluids such ...
Medicine Products: