Navigation Links
U-M researchers ID promising new cancer drug
Date:3/3/2008

ANN ARBOR, Mich. Researchers have long searched for a novel cancer drug that activates a certain protein to kill tumor cells. But finding a drug that kills the cancer without causing damage to normal cells has stymied researchers.

Now, researchers at the University of Michigan Comprehensive Cancer Center have designed a small molecule that is highly effective in cell cultures at inhibiting the interaction between this protein, called p53, and another protein that inactivates p53 in cancer. The new molecule is ideal for drug development as it can be given orally as a pill and it appears to be safe for use in animals.

For more than 10 years scientists have searched for ways to block p53 inhibition, but with little success. Our study clearly shows that this can be done, says study author Shaomeng Wang, Ph.D., Warner-Lambert/Parke-Davis Professor in Medicine at the U-M Medical School and co-director of the molecular therapeutics program at the U-M Comprehensive Cancer Center.

If clinical trials prove out the drugs promise, it could have potential for treating many different types of cancer. Results of the study appear the week of March 3 in the online edition of the Proceedings of the National Academy of Sciences.

The protein p53, which normally helps suppress tumors, is inactivated in almost all human cancers. About half the time, p53 does not do its job because the gene that holds the protein is mutated or missing altogether. The other half of the time, another protein, called human MDM2, is the culprit. It binds to p53 and inhibits the tumor suppressor function of p53, promoting cancer development.

Using a computer-assisted approach, U-M researchers designed a small molecule, called MI-219, that is highly effective in blocking the interaction of MDM2 and p53. MI-219 specifically kills tumor cells by harnessing the power of p53. In animal models of human cancer, MI-219 completely inhibited tumor growth and appeared to cause no toxicity to animals.

Many traditional cancer drugs also activate p53 but they do so by causing DNA damage. They kill not only tumor cells but also normal cells, thus having severe side effects. MI-219 is unique in that it is designed to activate p53 without causing DNA damage, specifically killing tumor cells. Indeed, MI-219 is highly effective in inhibiting tumor growth, and even inducing tumor regression, but it has caused no toxicity to animals at efficacious doses, says Wang, professor of internal medicine and pharmacology at the U-M Medical School and professor of medicinal chemistry at the U-M College of Pharmacy.

In addition to its effectiveness at killing cancer cells without toxic side effects, MI-219 can be developed as a pill that patients could take orally, rather than the traditional chemotherapy drugs that must be given intravenously at a hospital or cancer center.

While promising in preclinical studies, MI-219 needs to be evaluated in human clinical trials for its safety and efficacy for cancer treatment since it is a brand new drug, Wang cautions.

"We are very excited about the therapeutic potential of MI-219 for the treatment of many types of human cancer. Ascenta is committed to advancing MI-219, which we have designated AT-219, into human clinical trials," says study author Dajun Yang, M.D., Ph.D., senior vice president of research and a co-founder of Ascenta Therapeutics, a clinical-stage biopharmaceutical company that has licensed the technology related to MI-219 from U-M and plans to aggressively advance it into human clinical trials.


'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Related medicine news :

1. Researchers identify new genetic marker for breast cancer
2. Researchers describe mechanisms by which capon gene causes heart rhythm disturbances
3. Researchers develop new tool to predict who will use microbicides
4. USC researchers discover novel way to develop tumor vaccines
5. St. Jude Researchers Find Key Step in Programmed Cell Death
6. St. Jude researchers find key step in programmed cell death
7. Mayo Researchers Look for Explanation Behind High Incidence of Diabetes Among Asian Indians
8. Mayo researchers look for explanation behind high incidence of diabetes among Asian Indians
9. UT Southwestern researchers investigate predictors for sickle-cell-anemia complications
10. Researchers find possible target to treat deadly bloodstream infections
11. Rutgers researchers unlock mysteries of vitamin A metabolism during embryonic development
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
U-M researchers ID promising new cancer drug
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal their ... Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. , ... Pro X users can now reveal the media of their split screens with ...
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... TopConsumerReviews.com recently ... of Eyeglasses . , Millions of individuals in the United States and Canada ... become a way to both correct vision and make a fashion statement. Even celebrities ...
(Date:6/26/2016)... ... 2016 , ... PawPaws brand pet supplements owned by Whole Health ... the health of felines. The formula is all-natural and is made from Chinese herbs ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can ... Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey ... cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. ... his M.D from the David Geffen School of Medicine at UCLA. He trained in ... to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016  In a startling report released today, National Safety ... lacking a comprehensive, proven plan to eliminate prescription opioid overdoses. ... how states are tackling the worst drug crisis in recorded U.S. ... Kentucky , New Mexico , ... Of the 28 failing states, three – Michigan ...
(Date:6/23/2016)... WAYNE, Pa. , June 23, 2016 ... provider, will launch its next generation clinical outcomes platform, Bracket ... DIA Meeting held on June 26 – 30, 2016 in ... 6.0, the first electronic Clinical Outcome Assessment product of its ... DIA Booth #715. Bracket eCOA 6.0 is a ...
(Date:6/23/2016)... -- Guerbet announced today that it has been named a ... One of 12 suppliers to receive the ... of Premier members through exceptional local customer service and ... lower costs. "We ... customer service from Premier," says Massimo Carrara , ...
Breaking Medicine Technology: