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U-M launches effort to conquer common hospital-acquired infection
Date:8/26/2010

ANN ARBOR, Mich. Clostridium difficile, a wily, familiar bacterium, causes a growing number of serious infections in U.S. hospitals and nursing homes. With a $7.5 million, five-year award from the National Institutes of Health, University of Michigan researchers plan to discover what factors in the microbe and in patients make C. difficile a formidable, costly problem. C. difficile infects nearly a half-million Americans each year. U-M scientists and clinicians from many disciplines will conduct three interrelated projects that will focus on:

  1. the pathogen's genetic variations, to understand how pathogen variation leads to different disease outcomes
  2. the beneficial gut microbiota that, when altered by antibiotics, leave patients vulnerable to infection
  3. the human immune response to C. difficile infection.

The deeper knowledge should lead to better prevention measures, treatments and ways to keep infections from recurring, says U-M infectious disease specialist Vincent B. Young, M.D., Ph.D., who will direct the effort.

"If we can identify a deficiency in the host response, we may be able to develop a vaccine to compensate," Young says. "With increased knowledge of how a person's beneficial microbiota are altered by antibiotics, we can develop ways to give back microbiota that keep C. difficile in check." Young is associate professor in the U-M departments of internal medicine and microbiology and immunology.

C. difficile infections have doubled and grown more severe in recent years. Each year, 215,000 people in the United States are diagnosed with C. difficile infections while in hospitals or after a hospital stay. Another 263,000 develop C. difficile infections in nursing homes. The disease causes 28,500 deaths annually, according to the Centers for Disease Control and Prevention.

C. difficile infection causes mild to severe symptoms r
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Contact: Anne Rueter
arueter@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

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