Navigation Links
U-M launches effort to conquer common hospital-acquired infection
Date:8/26/2010

ANN ARBOR, Mich. Clostridium difficile, a wily, familiar bacterium, causes a growing number of serious infections in U.S. hospitals and nursing homes. With a $7.5 million, five-year award from the National Institutes of Health, University of Michigan researchers plan to discover what factors in the microbe and in patients make C. difficile a formidable, costly problem. C. difficile infects nearly a half-million Americans each year. U-M scientists and clinicians from many disciplines will conduct three interrelated projects that will focus on:

  1. the pathogen's genetic variations, to understand how pathogen variation leads to different disease outcomes
  2. the beneficial gut microbiota that, when altered by antibiotics, leave patients vulnerable to infection
  3. the human immune response to C. difficile infection.

The deeper knowledge should lead to better prevention measures, treatments and ways to keep infections from recurring, says U-M infectious disease specialist Vincent B. Young, M.D., Ph.D., who will direct the effort.

"If we can identify a deficiency in the host response, we may be able to develop a vaccine to compensate," Young says. "With increased knowledge of how a person's beneficial microbiota are altered by antibiotics, we can develop ways to give back microbiota that keep C. difficile in check." Young is associate professor in the U-M departments of internal medicine and microbiology and immunology.

C. difficile infections have doubled and grown more severe in recent years. Each year, 215,000 people in the United States are diagnosed with C. difficile infections while in hospitals or after a hospital stay. Another 263,000 develop C. difficile infections in nursing homes. The disease causes 28,500 deaths annually, according to the Centers for Disease Control and Prevention.

C. difficile infection causes mild to severe symptoms ranging from diarrhea to life-threatening colon inflammation.

Despite the availability of antibiotics to treat it, C. difficile increasingly recurs in some people. In contrast to many other hospital-acquired infections, recurrent C. difficile does not arise through antibiotic resistance, but through long-term changes in the makeup of the normal microbial inhabitants of the gut.

The multidisciplinary effort at U-M is one of four Cooperative Research Centers nationwide that will form the NIH-sponsored Enterics Research Investigational Network. The work brings together investigators with expertise in microbiology, immunology, clinical medicine, epidemiology, microbial ecology, evolutionary biology, animal modeling and bioinformatics. U-M's three interrelated projects tackle specific aspects of C. difficile pathogenesis.

Young will lead the overall consortium at U -M and will direct a project on the microbial ecology and molecular pathogenesis of C. difficile infection.

Another project, which explores the epidemiology and genomics of C. difficile infections, will involve collecting specimens from inpatients and outpatients at U-M Hospitals and Health Centers to discover the relationship between genetic factors of the pathogen and patient outcomes. David M. Aronoff, M.D., assistant professor of internal medicine in infectious diseases, will lead this effort.

Gary Huffnagle, Ph.D., U-M professor of microbiology and immunology and pulmonary and critical care, is co-principal investigator leading the final project, which will examine the interplay between host immunity and the pathogenesis of C. difficile.


'/>"/>

Contact: Anne Rueter
arueter@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Related medicine news :

1. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
2. Medical Transcription Services and EHR Provider MxSecure Launches New Enhanced Website with Goal of Improved Physician Productivity
3. MSU launches first anti-counterfeiting research program
4. ChangingHomeCare.com Launches Effort to Promote Future of Homecare
5. Bariatricfurnishings.com Launches Unique Eco-friendly Seating for Health Care, Hospitality, Assisted Living Centers, and Home Use at Competitive Prices
6. Akron Institute of Herzing University Launches Its First Bachelors Degree Programs to Prepare Students for Even Greater Success in Business, Health Care and IT
7. New SeaColonyTennis.net Launches to Promote World-Class Tennis Programs at Sea Colony
8. Hunk Calendar Photographer Resurrects Erotic Male Modeling Club and Launches Provocative E-exhibition
9. PA Breast Cancer Coalition Launches Income Tax Refund Campaign
10. Bluestar Silicones Launches a New Range of Silbione(R) TCS 7560 & 7561 Elastomers for Lingerie, Support Stockings and Medical Textile Applications
11. WebMD Launches New Version of Free Mobile Application for Physicians
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... Mediaplanet’s newest campaign, “Digestive Heath,” ... living proof that attitude and determination can combine into the most remarkable achievements. ... the holidays. This campaign will offer patients a new-found hope, by seizing the ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... Regency Waikiki Beach Resort and Spa in Honolulu, offering local frontline clinicians the ... pain management. , The demand for supplemental training related to pain management ...
(Date:12/2/2016)... ... December 02, 2016 , ... "Pro3rd Accents Volume 2 is a set ... lower third titles with just a few clicks of the mouse," said Christina Austin ... lower third animations. Choose from various styles with accented animations, rigid boxes, simplistic lines, ...
(Date:12/2/2016)... ... December 02, 2016 , ... ‘Tis the season for giving! Today, 20 creative ... National Family Partnership and the Drug Enforcement Administration as part of the National Red ... 10 winning schools who decorated their campuses with this year’s Red Ribbon Week theme: ...
(Date:11/30/2016)... Gardens, FL (PRWEB) , ... November 30, 2016 ... ... eating disorder and mental health treatment has announced the opening of a new ... specialized partial hospitalization and intensive outpatient treatment for adults and adolescents, both males ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... YORK , December 2, 2016 ... the trading session in red, while the Dow Jones Industrial ... at the close of US markets, which prompted Stock-callers this ... stocks: NuVasive Inc. (NASDAQ: NUVA ), Smith & ... (NASDAQ: NXTM ), and Cesca Therapeutics Inc. (NASDAQ: ...
(Date:12/2/2016)... OLD LYME, Conn. , Dec. 1, 2016 /PRNewswire/ ... consulting, has announced the honor of being selected as ... that include: Simpson Healthcare Executives Website at the PLATINUM ... Directed Conversations Training Module at the GOLD Level, and ... At Simpson Healthcare Executives, we are ...
(Date:12/2/2016)... Allergan plc (NYSE: AGN ), a ... previously announced Accelerated Share Repurchase (ASR) Program. Logo - ... ... previously announced, the Company entered into a variable tenor ASR ... repurchase $10 billion of its ordinary shares. Approximately 40.5 million ...
Breaking Medicine Technology: