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U-M Researchers ID Gene Involved in Pancreatic Cancer
Date:3/2/2009

ers found that ATDC is most highly expressed at the point when pre-cancerous cells become malignant. ATDC was also linked to increased levels of a signaling protein called beta-catenin, which is known to play a key role in cancer development.

Researchers believe ATDC has potential as a target for developing future therapies. It could also help doctors determine when a patient has pancreatic cancer and when it's chronic pancreatitis, a diagnosis that's often difficult to make without surgery. In some cases, this may allow patients to avoid an operation.

ATDC also appears to be involved in other cancer types, including bladder cancer and lung cancer. Researchers are continuing to investigate its role. This research was done in the laboratory. No tests or therapies related to ATDC are available at this time.

Pancreatic cancer statistics: 37,680 Americans will be diagnosed with pancreatic cancer this year and 34,290 will die from the disease, according to the American Cancer Society.

Additional authors: Lidong Wang, David G. Heidt, Cheong J. Lee, Huibin Yang, Eric R. Fearon and Mats Ljungman from U-M; Craig D. Logsdon from M.D. Anderson Cancer Center; and Lizhi Zhang from the Mayo Clinic.

Funding: National Institutes of Health, Lustgarten Foundation

Reference: Cancer Cell, Vol. 15, Issue 3, pp. 207-219

Resources:

U-M Cancer AnswerLine, 800-865-1125

U-M Comprehensive Cancer Center, www.mcancer.org


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SOURCE University of Michigan Comprehensive Cancer Center
Copyright©2009 PR Newswire.
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