Navigation Links
U-M News: Kidney failure risk higher for liver transplant patients following policy change

ANN ARBOR, Mich. Research from the University of Michigan Health System shows the risk for kidney failure among liver transplant recipients is higher following the implementation of Model of End Stage Liver Disease (MELD), a policy change in 2002 that altered how liver transplant allocation is decided.

The study, led by Pratima Sharma, M.D., M.S., an assistant professor in the Department of Internal Medicine, examined the effect of MELD score-based allocation on post-liver transplant kidney failure. MELD, which was introduced in 2002, is a scoring system that evaluates liver disease severity and has since become the basis for deciding which patients receive liver transplants.

The researchers found that the risk of developing post-transplant kidney failure among liver transplant recipients has increased by 15 percent in the MELD era compared to pre-MELD era. The findings were featured in the November 2011 issue of the American Journal of Transplantation.

"We're not aware of any prior study that has evaluated the impact of MELD-based liver allocation on the risk of new-onset post-transplant kidney failure," says Sharma. "These findings identify risk factors that could help prevent new-onset end stage renal failure in liver-transplant recipients."

The researchers previously found that the MELD score excessively weighs the presence of serum creatinine in deciding which patients receive liver transplants. Higher levels of serum creatinine are a sign of renal dysfunction.

When MELD was implemented, more patients with pre-transplant kidney dysfunction began receiving liver transplants. The incidence of simultaneous liver and kidney transplant has also increased significantly in the MELD era.

Researchers say that along with the increasing incidence of post-transplant kidney failure, chronic kidney disease could also be on the rise, affecting health care costs in the future.

"The higher incidence of post-transplant kidney failure may represent the tip of the iceberg," Sharma says. "Patients with chronic kidney disease could develop kidney failure in the future, which may add to already skyrocketing healthcare costs in terms of additional dialysis cases and increased hospitalization."

The findings also highlight several modifiable risk factors that could be addressed before, during or after liver transplant and help prevent post-transplant kidney failure.

The researchers found that along with African American race, hepatitis C, pre-liver-transplant diabetes, higher creatinine, lower albumin, low bilirubin and high sodium were significant predictors of post-liver transplant kidney failure.

"Modification of some of these risks that would improve renal function may help prevent or delay post-liver transplant kidney failure," Sharma says.


Contact: Justin Harris
University of Michigan Health System

Related medicine news :

1. Start spreading the news: NYU scientists find therapeutic target to stop cancer metastases
2. T3Leads Provides Latest Industry News: Imperative Information to Help Publishers Maximize Profits
3. Fowl news: Hints from Taiwan that free-range eggs may be less healthy than regular eggs
4. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
5. New drug for kidney transplant recipients effective in humans
6. Drug for advanced kidney cancer shrinks tumors prior to surgery
7. Obesity -- mild or severe -- raises kidney stone risk
8. VARI findings may help patients with deadly kidney cancer
9. Kidneys From Older Donors Suitable for Seniors
10. Comparison shows robot-assisted option offers advantages for kidney surgery
11. Walk KidneyWise Los Angeles to Help Launch KidneyWise with Fundraising Walk in Santa Monica
Post Your Comments:
(Date:10/13/2015)... , ... October 13, 2015 , ... "My friend's son ... fists into his infected cheeks," said an inventor from Platteville, Colo. "I came up ... problems." , He developed the UNTOUCHABLE to prevent a child from rubbing or scratching ...
(Date:10/13/2015)... ... October 13, 2015 , ... ProText Kinetic Panel is ... With ProText Kinetic Panel, users can create energetic text animations in any layout without ... the Final Cut Pro X timeline and stylize the text. With intuitive on-screen controls, ...
(Date:10/13/2015)... ... October 13, 2015 , ... Relay (, a ... announced today a significant contract that will provide its award-winning private messaging solution ... on the growing success of its Relay program, IBX Wire™, which now has ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... of Anik Singal's newly launched "Publish Academy" training course . Singal's new ... opened for enrollment today, and marketers around the Internet are weighing in with ...
(Date:10/13/2015)... ... October 13, 2015 , ... T-System and Centegra Health ... 59,000 emergency department visits per year, today announced the successful and rapid deployment ... clinical, operational and financial outcomes. , In less than four days, ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... 2015 Families across the country have ... to the pharmaceutical company,s blockbuster anti-nausea drug Zofran ... caused by their fraudulent misrepresentations to prescribing physicians ... pregnant women.   Due to the large number of ... States Judicial Panel on Multidistrict Litigation (JPML) has ...
(Date:10/13/2015)... , Oct. 13, 2015   Generational Equity , ... businesses, is pleased to announce the acquisition of its ... Largo, Florida , by Meridian Biomedical, ... September 11, 2015. Florida ... --> Florida . To learn more, ...
(Date:10/13/2015)... 13, 2015 According to the ... sponsored by Cardinal Health , achieving both ... diversified pharmacy revenue streams are vital to the ... NCPA Digest affirms that independent community ... in underserved inner city and rural areas," said ...
Breaking Medicine Technology: