Navigation Links
U-M News: Kidney failure risk higher for liver transplant patients following policy change
Date:1/17/2012

ANN ARBOR, Mich. Research from the University of Michigan Health System shows the risk for kidney failure among liver transplant recipients is higher following the implementation of Model of End Stage Liver Disease (MELD), a policy change in 2002 that altered how liver transplant allocation is decided.

The study, led by Pratima Sharma, M.D., M.S., an assistant professor in the Department of Internal Medicine, examined the effect of MELD score-based allocation on post-liver transplant kidney failure. MELD, which was introduced in 2002, is a scoring system that evaluates liver disease severity and has since become the basis for deciding which patients receive liver transplants.

The researchers found that the risk of developing post-transplant kidney failure among liver transplant recipients has increased by 15 percent in the MELD era compared to pre-MELD era. The findings were featured in the November 2011 issue of the American Journal of Transplantation.

"We're not aware of any prior study that has evaluated the impact of MELD-based liver allocation on the risk of new-onset post-transplant kidney failure," says Sharma. "These findings identify risk factors that could help prevent new-onset end stage renal failure in liver-transplant recipients."

The researchers previously found that the MELD score excessively weighs the presence of serum creatinine in deciding which patients receive liver transplants. Higher levels of serum creatinine are a sign of renal dysfunction.

When MELD was implemented, more patients with pre-transplant kidney dysfunction began receiving liver transplants. The incidence of simultaneous liver and kidney transplant has also increased significantly in the MELD era.

Researchers say that along with the increasing incidence of post-transplant kidney failure, chronic kidney disease could also be on the rise, affecting health care costs in the future.

"The higher incidence of post-transplant kidney failure may represent the tip of the iceberg," Sharma says. "Patients with chronic kidney disease could develop kidney failure in the future, which may add to already skyrocketing healthcare costs in terms of additional dialysis cases and increased hospitalization."

The findings also highlight several modifiable risk factors that could be addressed before, during or after liver transplant and help prevent post-transplant kidney failure.

The researchers found that along with African American race, hepatitis C, pre-liver-transplant diabetes, higher creatinine, lower albumin, low bilirubin and high sodium were significant predictors of post-liver transplant kidney failure.

"Modification of some of these risks that would improve renal function may help prevent or delay post-liver transplant kidney failure," Sharma says.


'/>"/>

Contact: Justin Harris
juaha@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Related medicine news :

1. Start spreading the news: NYU scientists find therapeutic target to stop cancer metastases
2. T3Leads Provides Latest Industry News: Imperative Information to Help Publishers Maximize Profits
3. Fowl news: Hints from Taiwan that free-range eggs may be less healthy than regular eggs
4. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
5. New drug for kidney transplant recipients effective in humans
6. Drug for advanced kidney cancer shrinks tumors prior to surgery
7. Obesity -- mild or severe -- raises kidney stone risk
8. VARI findings may help patients with deadly kidney cancer
9. Kidneys From Older Donors Suitable for Seniors
10. Comparison shows robot-assisted option offers advantages for kidney surgery
11. Walk KidneyWise Los Angeles to Help Launch KidneyWise with Fundraising Walk in Santa Monica
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... New York, NY (PRWEB) , ... December 02, 2016 , ... ... Through an exclusive interview with Mediaplanet, Dr. Murthy explains how he was inspired to ... “Early on I learned that medicine is about more than making diagnoses and prescribing ...
(Date:12/2/2016)... ... 02, 2016 , ... Mediaplanet is proud to announce the ... the innovative treatments, therapeutic technologies, and revolutionized nutrition that are helping patients and ... 6 years in the last 3 decades,” says Dr. Valentine Fuster, a world-renowned ...
(Date:12/2/2016)... ... , ... Rijuven Corp launches rejiva ( http://www.rejiva.com ), a unique wearable technology ... health technology on the market can deliver all that rejiva can. , “Rejiva promotes ... their health than the usual heart rate and steps taken”, adds Evens Augustin, CEO ...
(Date:12/2/2016)... ... December 02, 2016 , ... Today CloudMine, a secure, cloud-based ... named the best Sales Team of 2016 as part of the 2016 SIIA ... the Software & Information Industry Association (SIIA), the principal trade association for the ...
(Date:11/30/2016)... ... 2016 , ... "I hate when the mixture of saliva and toothpaste runs ... inventor from Bridgewater, N.J. "I thought that there had to be a way to ... the patent-pending DEFLECTOR to prevent saliva and toothpaste from running down the brush handle ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... British Columbia , December 2, 2016 - bioLytical lanza ... las nuevas directrices de la OMS     Continue Reading ... ... , , ... de enfermedades infecciosas, ha anunciado hoy que está expandiendo el lanzamiento de su ...
(Date:12/2/2016)... , December 2, 2016 Persistence ... pacemaker market in its upcoming report titled, "Global Market Study on ... Declining CAGR of -1.4% between 2016 and 2024". The global ... in 2015 and this is likely to decline to ... the global cardiac pacemaker market is anticipated to exhibit ...
(Date:12/2/2016)... , Dec. 2, 2016  LifeVac, the revolutionary device ... in the Emergency Response Training and Support Services (ERTSS) ... to have LifeVac become part of the ERTSS mission ... and CEO of LifeVac. "Having an established network of ... effectively will help leverage our efforts to spread LifeVac,s ...
Breaking Medicine Technology: