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Typical IBD patients not represented in research studies
Date:8/22/2012

Major randomized controlled trials of new therapies for inflammatory bowel disease (IBD) are conducted on patients who are not typical of those who physicians see in day-to-day practice, according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association (AGA).

The two major, often debilitating, illnesses that are recognized as IBD are ulcerative colitis and Crohn's disease. The introduction of biologics the most prescribed medications for IBD patients have dramatically impacted the ability to manage disease activity. However, a substantial percentage of IBD patients will have no response to these medications or lose response over time. This fact not only highlights the need for additional investigation of therapeutic targets, but also strategies to identify the optimal scenario for greatest therapeutic effect.

"Many outpatients with moderate-to-severe inflammatory bowel disease may not qualify for trials of new treatment options," said Christina Ha, MD, of the Johns Hopkins School of Medicine and lead author of this study. "Because of the heterogeneity of the inflammatory bowel disease patient population in terms of age of onset, disease behavior and severity, many patients may not meet the strict entry criteria for clinical trial participation. However, we often presume similar therapeutic effect among our clinic patients as demonstrated in clinical trials."

Researchers from the Johns Hopkins School of Medicine, Mount Sinai School of Medicine and Dartmouth-Hitchcock Medical Center performed a retrospective cohort study of 206 adult patients with moderate-to-severe IBD who went to the Mount Sinai Medical Center for an adjustment of their medical therapy from January 2008 to June 2009. Of these patients, only 31.1 percent would have been eligible to participate in a randomized controlled clinical trial of biologics. Reasons for exclusio
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Contact: Alissa J. Cruz
media@gastro.org
301-272-1603
American Gastroenterological Association
Source:Eurekalert

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