Navigation Links
Type of viral infection of eye associated with disease causing blindness in the elderly
Date:5/21/2012

ATLANTA A team of researchers, including a scientist from the Viral Immunology Center at Georgia State University, have found that a type of herpesvirus infection of the eye is associated with neovascular age-related macular degeneration (AMD), a disease that causes blindness in the elderly.

The scientists found that human cytomegalovirus, a type of herpesvirus, causes the production of vascular endothelial growth factor, or VEGF, a signal protein that regulates the formation of new blood vessels.

With the formation of new blood vessels, retinal tissue destruction occurs, leading to the development of "wet" AMD and eventually, vision loss and blindness. The results were published in PLoS Pathogens, a journal of the Public Library of Science.

"Prior to this work, cofactors for the development of AMD included genetics, a high fat diet and smoking. Now, we are adding an infections agent as another cofactor," said Richard D. Dix, professor at the Georgia State Viral Immunology Center's Ocular Virology and Immunology Laboratory.

The research team includes Dix, Scott W. Cousins, Diego G. Espinosa-Heidmann, Daniel M. Miller, Simone Pereira-Simon, Eleut P. Hernandez, Hsin Chien and Courtney Meier-Jewett.

Affiliated research institutions include the Duke University Eye Center, the Bascom Palmer Eye Institute of the University of Miami Miller School of Medicine, the Viral Immunology Center at Georgia State, and the Department of Ophthalmology at the Emory University School of Medicine.

Human cytomegalovirus is a common herpesvirus, said Dix, who is also an adjunct professor of ophthalmology at the Emory University School of Medicine. About 80 percent of the population is estimated to have antibodies for the virus, and it is often acquired during childhood.

If a person has a normal, healthy immune system, the virus becomes latent in the cells of bone marrow and blood, he said. But in the elderly, the immune system's function is reduced, the virus proliferates, and the production of VEGF increases.

Identifying human cytomegalovirus as a cofactor in the development of AMD opens up new paths for the treatment of AMD, Dix said. One route could include reducing the viral load the amount of the human cytomegalovirus in the blood stream by treatment with an antiviral drug known as ganciclovir.

Additional research paths include looking at the genetics involved in the upregulation of VEGF by human cytomegalovirus.

"If we can knock down a certain gene or genes of the virus that stimulates VEGF production, we might be able to decrease it production and minimize AMD," Dix said.


'/>"/>

Contact: Jeremy Craig
jcraig@gsu.edu
404-413-1357
Georgia State University
Source:Eurekalert

Related medicine news :

1. Gastroenterology special issue focuses on new directions of viral hepatitis care and research
2. A*STAR scientists discover switch to boost anti-viral response to fight infectious diseases
3. Pig stomach mucins are effective as anti-viral agents for consumer products
4. Junk DNA can sense viral infection
5. Video publication goes viral
6. UC San Diego among first in nation to treat brain cancer with novel viral vector
7. Ragon Institute study finds HIV-specific CD4 cells that control viral levels
8. Partners Viral Load a Major Factor in HIV Transmission: Study
9. Viral load a major factor affecting risk of sexually transmitting HIV
10. Pep talk can revive immune cells exhausted by chronic viral infection
11. Ohio State researchers design a viral vector to treat a genetic form of blindness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... First ... United States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell ... facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive ...
(Date:6/25/2016)... Oklahoma City, Oklahoma (PRWEB) , ... June 25, ... ... to helping both athletes and non-athletes recover from injury. Recently, he has implemented ... for the Oklahoma City area —Johnson is one of the first doctors to ...
(Date:6/25/2016)... ... 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s a ... the bar too high can result in disappointment, perhaps even self-loathing. However, those who ... , Research from PsychTests.com reveals that behind the tendency to set ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events ... turn to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. ... tools for healthy coping following a traumatic event. , Trauma sufferers tend to feel ...
(Date:6/24/2016)... ... ... a crisis. Her son James, eight, was out of control. Prone to extreme mood shifts ... upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife ... and say he was going to kill them. If we were driving on the ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 ... Tomorrow,s Leaders Scholarship is any indication, the future is ... online at www.diabetesscholars.org by the Diabetes Scholars ... in the way of academic and community service excellence. ... program since 2012, and continues to advocate for people ...
(Date:6/23/2016)... 2016 Revolutionary technology includes multi-speaker ... , industry leaders in advanced audiology and hearing aid ... Opn ™, the world,s first internet connected hearing aid ... devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) ... of ,world firsts,: , TwinLink™ - the ...
(Date:6/23/2016)... 23, 2016 The vast majority of dialysis ... facility.  Treatments are usually 3 times a week, with ... including travel time, equipment preparation and wait time.  This ... grueling for patients who are elderly and frail.  Many ... and rehabilitation centers for some duration of time. ...
Breaking Medicine Technology: