Navigation Links
Type 2 diabetes and insulin use are associated with colorectal cancer in men
Date:10/18/2010

There is an association between type 2 diabetes mellitus and colorectal cancer (CRC) among men, but not women, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute.

In 2000, the prevalence of type 2 diabetes was approximately 171 million worldwide, and 366 million people are projected to have the disease by 2030. Obesity, western-style diet and lack of physical activity are established risk factors for CRC. Hyperglycemia and hyperinsulinemia, which are especially pronounced during the early stages of type 2 diabetes, have been proposed as mediators for the association between CRC and type 2 diabetes. Although it is known that type 2 diabetes is associated with an increased risk of CRC, it is not clear if this association varies by gender or other factors.

"While our study supports an association of type 2 diabetes with colorectal cancer incidence among men, our results also suggest that insulin use is associated with a slight, but not a substantially increased, risk of colorectal cancer among men with type 2 diabetes," said Peter T. Campbell, PhD, of the American Cancer Society and lead author of this study. "Prevention strategies should emphasize adherence to guidelines intended for the general population such as smoking cessation, weight management, exercise and regular early detection exams." Watch Dr. Campbell discuss his study at http://www.youtube.com/watch?v=yn0G1O6eqWU.

In the final study of 73,312 men and 81,663 women, 1,567 men (227 with type 2 diabetes) and 1,242 women (108 with type 2 diabetes) were diagnosed with colon or rectal cancer by 2007. Among men, type 2 diabetes was associated with increased risk of incident CRC compared to not having type 2 diabetes. CRC risk was higher for those participants with type 2 diabetes regardless of whether or not they used insulin.

Among women, type 2 diabetes and insulin use were not associated with CRC risk. These findings support recent observations that the association may be more prominent in men than in women, and raise the possibility of a stronger association among individuals with a family history of CRC. This finding could have clinical relevance if confirmed by other large studies. The authors speculate that the lack of an association between type 2 diabetes and CRC risk among women might relate to improved glucose control among women with type 2 diabetes in recent years.

Participants were selected from the Cancer Prevention Study II Nutrition Cohort, a prospective study of cancer incidence. In 1992 or 1993, 184,194 adult participants completed a detailed, self-administered questionnaire. Follow-up questionnaires were sent in 1997 and every two years thereafter.


'/>"/>

Contact: Alissa J. Cruz
media@gastro.org
301-272-1603
American Gastroenterological Association
Source:Eurekalert

Related medicine news :

1. Hospitalizations Way Up for Young Adults With Diabetes
2. Can Wii help control gestational diabetes?
3. Metabolic status before pregnancy predicts subsequent gestational diabetes
4. Diabetes gene linked to degeneration of enzyme involved in Alzheimers disease onset and progression
5. UT Southwestern study to determine whether leptin helps type 1 diabetes patients
6. Study links large waist size to higher diabetes rates among Americans
7. Patient-provider language barriers linked to worse diabetes control
8. Experts advocate realigning type 2 diabetes treatments with diseases natural history
9. Heart, kidney, diabetes and cancer MEP groups league against chronic disease to seek European commitment
10. Lifestyle intervention improves risk factors in type 2 diabetes
11. Type 1 diabetes research at UC San Diego gets $5 million boost
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... ... February 11, 2016 , ... Life is known for throwing curves. ... and older, who gather once a year to play softball to raise money through ... game, the more than 50 players who competed in this year’s softball tournament share ...
(Date:2/11/2016)... ... ... Colorado spine surgeon, Donald Corenman, MD, DC has been selected by ... . The list consists of spine surgeons across the country nominated by their peers ... importance of clinical excellence; he has been awarded the Patient’s Choice Award, Compassionate Doctor ...
(Date:2/11/2016)... ... 2016 , ... Talix today announced that Clive Fields, MD, ... at the 2016 HIMSS Annual Conference & Exhibition, taking place February 29 – ... Coding for Care: Using Data Analytics for Risk Adjustment ,” Dr. Fields will ...
(Date:2/11/2016)... AR (PRWEB) , ... February 11, 2016 , ... Dickinson ... their community by announcing a new fundraiser in support of a local boy named ... hopes the campaign will bring awareness to, and rally support for, all local families ...
(Date:2/11/2016)... ... February 11, 2016 , ... Pixel Film Studios brings ... with customizable backdrops in the Christmas edition of the ProDrop series. Pick and choose ... audiences and invoke the spirit of Christmas using ProDrop's wintry generators. ProDrop Christmas is ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... Breast Cancer Therapeutics in Asia-Pacific Markets ... (APAC) breast cancer market will experience considerable expansion ... at a Compound Annual Growth Rate (CAGR) of 8.5%. ... - states that the Asia-Pacific ... billion in 2014 to $3.4 billion by 2021, at a ...
(Date:2/11/2016)... , Feb. 11, 2016 PLAD, Inc. ... out 2016 with sales exceeding company targets, are adding ... received their trademark from the United States Patent and ... Clark , Chief Executive Officer of PLAD, Inc.  In ... Pennsylvania with two new customers, ...
(Date:2/11/2016)... 11, 2016  M3 Biotechnology Inc., spurred by a major "team investment" by Bruce Montgomery ... completed an oversubscribed Series A-Round, according to CEO Leen Kawas , PhD. ... ... ... Kawas said ...
Breaking Medicine Technology: