Navigation Links
Type 2 diabetes and insulin use are associated with colorectal cancer in men
Date:10/18/2010

There is an association between type 2 diabetes mellitus and colorectal cancer (CRC) among men, but not women, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute.

In 2000, the prevalence of type 2 diabetes was approximately 171 million worldwide, and 366 million people are projected to have the disease by 2030. Obesity, western-style diet and lack of physical activity are established risk factors for CRC. Hyperglycemia and hyperinsulinemia, which are especially pronounced during the early stages of type 2 diabetes, have been proposed as mediators for the association between CRC and type 2 diabetes. Although it is known that type 2 diabetes is associated with an increased risk of CRC, it is not clear if this association varies by gender or other factors.

"While our study supports an association of type 2 diabetes with colorectal cancer incidence among men, our results also suggest that insulin use is associated with a slight, but not a substantially increased, risk of colorectal cancer among men with type 2 diabetes," said Peter T. Campbell, PhD, of the American Cancer Society and lead author of this study. "Prevention strategies should emphasize adherence to guidelines intended for the general population such as smoking cessation, weight management, exercise and regular early detection exams." Watch Dr. Campbell discuss his study at http://www.youtube.com/watch?v=yn0G1O6eqWU.

In the final study of 73,312 men and 81,663 women, 1,567 men (227 with type 2 diabetes) and 1,242 women (108 with type 2 diabetes) were diagnosed with colon or rectal cancer by 2007. Among men, type 2 diabetes was associated with increased risk of incident CRC compared to not having type 2 diabetes. CRC risk was higher for those participants with type 2 diabetes regardless of whether or not they used insulin.

Among women, type 2 diabetes and insulin use were not associated with CRC risk. These findings support recent observations that the association may be more prominent in men than in women, and raise the possibility of a stronger association among individuals with a family history of CRC. This finding could have clinical relevance if confirmed by other large studies. The authors speculate that the lack of an association between type 2 diabetes and CRC risk among women might relate to improved glucose control among women with type 2 diabetes in recent years.

Participants were selected from the Cancer Prevention Study II Nutrition Cohort, a prospective study of cancer incidence. In 1992 or 1993, 184,194 adult participants completed a detailed, self-administered questionnaire. Follow-up questionnaires were sent in 1997 and every two years thereafter.


'/>"/>

Contact: Alissa J. Cruz
media@gastro.org
301-272-1603
American Gastroenterological Association
Source:Eurekalert

Related medicine news :

1. Hospitalizations Way Up for Young Adults With Diabetes
2. Can Wii help control gestational diabetes?
3. Metabolic status before pregnancy predicts subsequent gestational diabetes
4. Diabetes gene linked to degeneration of enzyme involved in Alzheimers disease onset and progression
5. UT Southwestern study to determine whether leptin helps type 1 diabetes patients
6. Study links large waist size to higher diabetes rates among Americans
7. Patient-provider language barriers linked to worse diabetes control
8. Experts advocate realigning type 2 diabetes treatments with diseases natural history
9. Heart, kidney, diabetes and cancer MEP groups league against chronic disease to seek European commitment
10. Lifestyle intervention improves risk factors in type 2 diabetes
11. Type 1 diabetes research at UC San Diego gets $5 million boost
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/21/2017)... ... February 21, 2017 , ... Individuals who have been ... to surgery, treatment, therapy and management. Regular exercise in proper environments has been ... despite their diseases. On February 23, 2017, 1:00-2:00 p.m. E.S.T., a dynamic ...
(Date:2/21/2017)... ... February 21, 2017 , ... ... coverage in veterinary medicine, will be launching its first bi-monthly issue of 2017 ... medicine, business and practice management, and One Health. , In making the ...
(Date:2/21/2017)... ... February 21, 2017 , ... ... the predictive analytic firm Predixion’s Healthcare IT practice. Predixion, which raised $42M+ to ... backed by giants including Accenture, GE Ventures, and Software AG , will ...
(Date:2/21/2017)... , ... February 21, 2017 , ... A February 6 ... gastric balloons for weight loss. It found that the treatments have led to significant ... patients, when compared to unassisted efforts. It also noted very few problematic results relating ...
(Date:2/20/2017)... Ill. (PRWEB) , ... February 20, 2017 , ... ... to reduce the rate at which women are called back for additional examinations ... journal Radiology . , In 2011, the U.S. Food and Drug Administration ...
Breaking Medicine News(10 mins):
(Date:2/21/2017)... Research and Markets has announced the addition of ... Report" report to their offering. ... The report provides separate comprehensive analytics for the US, ... , Asia-Pacific , Latin America ... the period 2015 through 2022. Also, a six-year historic analysis is provided ...
(Date:2/21/2017)... DUBLIN , Feb. 21, 2017 Research and ... and Strategies - 2016" report to their offering. ... The latest research Anthrax Drugs Price Analysis ... global Anthrax market. The research answers the following questions: ... their clinical attributes? How are they positioned in the Global Anthrax market? ...
(Date:2/20/2017)... , Feb. 20, 2017 Provides understanding ... and agreements entered into by the worlds leading ... https://www.reportbuyer.com/product/3605699/ Description The Global Renal Failure ... understanding and access to partnering deals and agreements ... - Trends in partnering deals ...
Breaking Medicine Technology: