Navigation Links
Type 2 diabetes: New associations identified between genes and metabolic markers
Date:10/30/2013

In two comprehensive studies, scientists from Helmholtz Zentrum Muenchen, Ludwig-Maximilians-Universitaet Muenchen and Technische Universitaet Muenchen discovered new associations of two major Type 2 diabetes risk genotypes and altered plasma concentrations of metabolic products. The "Virtual Institute Diabetes" joint research cooperation is thereby making an important contribution towards explaining the genetic and molecular basis of diabetes, The results have been published in the journals PLOS ONE and Metabolomics.

For these investigations, participants of the population-based cohort study KORA* carrying high-risk diabetes gene variants without having a diagnosed diabetes, as well as participants without an increased diabetes risk were recruited.

All study participants were subjected to a metabolic load. The nutritients, particularly sugars and fats, were administered either orally or intravenously. The scientists subsequently determined the concentrations of 163 metabolic products in blood samples from the participants. The teams headed by Prof. Dr. Thomas Illig (HMGU) and Dr. Harald Grallert (HMGU), Prof. Dr. Jochen Seiler (LMU), and Prof. Dr. Hans Hauner (TUM) and Dr. Helmut Laumen (TUM) were the first to supply a comprehensive characterisation of the metabolic performance in regard to the respective genotype.

It was observed that the concentrations of the recorded substances represent a particular metabolomic response pattern depending on the genotype. It was possible to verify specific metabolic effects, particularly for the TCF7L2 genotype, which is associated with an increased risk of type 2 diabetes. "We are aware of certain high-risk gene variants for type 2 diabetes. However, the causative mechanisms on the path to this disease are still largely unknown. With our results, we are helping to close the gap between disease-associated genes on the one hand and the development of diabetes on the other. A typically changed metabolic performance can supply early indications of diabetes", explain Simone Wahl from HMGU and Cornelia Then from LMU, first authors of the two publications.

The scientists are currently investigating metabolic responses in additional genotypes. The objective is to advance the fundamental research on the widespread disease diabetes and to contribute the acquired knowledge to the clinical cooperation groups that have developed from the VID in order to promote the knowledge transfer between the laboratory and clinical care of patients suffering from diabetes.


'/>"/>

Contact: Dr. Harald Grallert
harald.grallert@helmholtz-muenchen.de
49-893-187-1195
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health
Source:Eurekalert

Related medicine news :

1. 1 in 8 Americans Diagnosed With Type 2 Diabetes: Poll
2. Fewer U.S. Kids Dying of Diabetes: CDC
3. Hispanics May Face Higher Risk for Type 2 Diabetes: Study
4. Obesity in type 2 diabetes: Recommendations from guidelines are largely consistent
5. Disrupted Sleep May Raise Risk for Obesity, Diabetes: Study
6. Pollen Allergy Relief with Raw Honey From Alexandria Bay, Chenango and Ballston Spa, New York Beekeeping Associations
7. Briefing explores associations between air pollution and health outcomes
8. Seminar on Sport-Related Head Injuries Offered by the Eastern and New York State Athletic Trainers’ Associations Aims to Educate Families of Youth Athletes
9. Associations linking weight to breast cancer survival vary by race/ethnicity
10. New Genetic Error in Some Lung Cancers Identified by CU Scientists
11. Predictors of substance abuse identified among teens with bipolar disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... ... ... Florida Hospital presents Heart Health Awareness night on Sunday February 14th, as ... The puck drops at 6:00pm, but fans will have the opportunity to experience the ... The MEGA Heart will be located on Ford Thunder Alley and provide fans with ...
(Date:2/11/2016)... ... February 11, 2016 , ... The president released a FY 2017 ... but would shift more of the cost burden to military beneficiaries. , MOAA’s ... in the defense budget as including limited quantifiable benefit fixes mixed with numerous beneficiary ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... discuss how to improve care by making data on heart procedures public and ... Summit on Transparency and Public Reporting of Pediatric and Congenital Heart Disease Outcomes ...
(Date:2/11/2016)... ... February 11, 2016 , ... Atlantic Information Services, ... Benefit Model: A Case Study for Plans and Purchasers.” Executives from Intel Corp. ... with Intel on value-based health benefits program Connected Care, will discuss the challenges ...
(Date:2/11/2016)... ... 11, 2016 , ... "What holds you back from ... a question as a challenge for his readers to examine the full scale ... (published by Partridge Singapore), Clarke explores the subject with more depth, revealing time-honored ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... Feb. 11, 2016  Walgreens has committed to provide ... and Washington, D.C. as part of ... was commended by shareholder advocacy organization As You Sow. ... Sow. "Many people hold on to unneeded drugs because they ... tragic consequences." --> Conrad MacKerron , Senior ...
(Date:2/11/2016)... , Feb. 11, 2016   Health 2.0 ... of new health technologies, announced today " 10 Year ... in health tech over the past ten years.   ... nearly a decade, Health 2.0 has served as the ... and connected with thousands of technologies, companies, innovators, and ...
(Date:2/11/2016)... Calif. , Feb. 11, 2016  NOIT™ Research ... a special "Gift of Change" campaign to assist needy ... For every such unit sold between February 10, 2016 ... unit to a needy family. The NOIT is an ... non/limited-verbal autistic individuals develop language skills. ...
Breaking Medicine Technology: