Navigation Links
Type 2 diabetes: New associations identified between genes and metabolic markers
Date:10/30/2013

In two comprehensive studies, scientists from Helmholtz Zentrum Muenchen, Ludwig-Maximilians-Universitaet Muenchen and Technische Universitaet Muenchen discovered new associations of two major Type 2 diabetes risk genotypes and altered plasma concentrations of metabolic products. The "Virtual Institute Diabetes" joint research cooperation is thereby making an important contribution towards explaining the genetic and molecular basis of diabetes, The results have been published in the journals PLOS ONE and Metabolomics.

For these investigations, participants of the population-based cohort study KORA* carrying high-risk diabetes gene variants without having a diagnosed diabetes, as well as participants without an increased diabetes risk were recruited.

All study participants were subjected to a metabolic load. The nutritients, particularly sugars and fats, were administered either orally or intravenously. The scientists subsequently determined the concentrations of 163 metabolic products in blood samples from the participants. The teams headed by Prof. Dr. Thomas Illig (HMGU) and Dr. Harald Grallert (HMGU), Prof. Dr. Jochen Seiler (LMU), and Prof. Dr. Hans Hauner (TUM) and Dr. Helmut Laumen (TUM) were the first to supply a comprehensive characterisation of the metabolic performance in regard to the respective genotype.

It was observed that the concentrations of the recorded substances represent a particular metabolomic response pattern depending on the genotype. It was possible to verify specific metabolic effects, particularly for the TCF7L2 genotype, which is associated with an increased risk of type 2 diabetes. "We are aware of certain high-risk gene variants for type 2 diabetes. However, the causative mechanisms on the path to this disease are still largely unknown. With our results, we are helping to close the gap between disease-associated genes on the one hand and the development of diabetes on the other. A typically changed metabolic performance can supply early indications of diabetes", explain Simone Wahl from HMGU and Cornelia Then from LMU, first authors of the two publications.

The scientists are currently investigating metabolic responses in additional genotypes. The objective is to advance the fundamental research on the widespread disease diabetes and to contribute the acquired knowledge to the clinical cooperation groups that have developed from the VID in order to promote the knowledge transfer between the laboratory and clinical care of patients suffering from diabetes.


'/>"/>

Contact: Dr. Harald Grallert
harald.grallert@helmholtz-muenchen.de
49-893-187-1195
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health
Source:Eurekalert

Related medicine news :

1. 1 in 8 Americans Diagnosed With Type 2 Diabetes: Poll
2. Fewer U.S. Kids Dying of Diabetes: CDC
3. Hispanics May Face Higher Risk for Type 2 Diabetes: Study
4. Obesity in type 2 diabetes: Recommendations from guidelines are largely consistent
5. Disrupted Sleep May Raise Risk for Obesity, Diabetes: Study
6. Pollen Allergy Relief with Raw Honey From Alexandria Bay, Chenango and Ballston Spa, New York Beekeeping Associations
7. Briefing explores associations between air pollution and health outcomes
8. Seminar on Sport-Related Head Injuries Offered by the Eastern and New York State Athletic Trainers’ Associations Aims to Educate Families of Youth Athletes
9. Associations linking weight to breast cancer survival vary by race/ethnicity
10. New Genetic Error in Some Lung Cancers Identified by CU Scientists
11. Predictors of substance abuse identified among teens with bipolar disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... ... January 23, 2017 , ... Steviva Ingredients, makers ... under the USDA National Organic Program (NOP) for its Portland SQF Level 2 ... organic production and handling systems to complement our current rigorous food-safety management systems,” ...
(Date:1/23/2017)... , ... January 23, 2017 , ... “The Inn at the Mill”: a story ... fears in her quest to become happy and content. , “The Inn at the ... has also lived in Germany and Vermont and is now living in Berks County on ...
(Date:1/23/2017)... ... 23, 2017 , ... Valentine’s Day is a time when many people celebrate romance and love ... may be looking for the ideal present, Atlanta-based Perimeter Plastic Surgery is offering ... free. Or, spend $200 and get $50 free. , “A lot of people just ...
(Date:1/21/2017)... ... 21, 2017 , ... Caronlab Australia, an Australian company known for health and ... Hilton Head, SC, where it benefited from outstanding meetings with major retail buyers. , ... wellness products. At this trade show, the company had the chance to demonstrate its ...
(Date:1/21/2017)... Barbara, CA (PRWEB) , ... January 21, 2017 ... ... its Director of Alumni Relations, Dianne Travis-Teague, the electrifying line-up of events for ... festivities for alumni, family, friends, and community. “Coming Home 2017” will be ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... , Jan. 23, 2017  Based on its ... & Sullivan recognizes Ansell, a global leader in ... Sullivan Company of the Year Award. Ansell,s comprehensive ... a wide global footprint have placed it in ... protection market. The Company,s established product line and ...
(Date:1/23/2017)... , Jan. 23, 2017 Research and ... Market - Forecast to 2021" report to their offering. ... The interventional radiology ... from USD 6.35 Billion in 2016, at a CAGR of 4.8%. ... The major factors driving the growth of this market ...
(Date:1/23/2017)... Jan. 23, 2017 MouthWatch LLC announced today that ... ranked as the best intraoral camera on DentalCompare,s list of ... spot overall. The #1 product was the CollaPlug Absorbable ... intraoral camera was "…incredibly popular because it is by far ... a small sticker price, it doesn,t sacrifice quality imaging." ...
Breaking Medicine Technology: