In comparing bleeding events, the researchers reported 13 hemorrhagic strokes, with no statistically significant difference between aspirin takers and non-takers (six such strokes in the aspirin group; seven in the non-aspirin group).
On the other hand, the total number of all hemorrhagic events was greater in the aspirin group compared to the non-aspirin group (34 vs. 10 such events). Four patients in the aspirin group had bleeding events that required transfusion. Furthermore, those in the aspirin group had more gastrointestinal symptoms (55 cases vs. eight cases), but all cases were resolved without surgery and no fatalities occurred, he said.
"Our findings need to be interpreted in the context of the low incidence of atherosclerotic disease in Japan," Ogawa said. "We conclude that aspirin as primary prevention is beneficial at least for fatal heart attack and fatal stroke in our entire study group and for all atherosclerotic disease among those age 65 or over."
Co-authors are: Masafumi Nakayama, M.D., Ph.D.; Takeshi Morimoto, M.D., Ph.D.; Shiro Uemura, M.D., Ph.D.; Masao Kanauchi, M.D., Ph.D.; Naofumi Doi, M.D., Ph.D.; Seigo Sugiyama, M.D., Ph.D.; and Yoshihiko Saito, M.D., Ph.D. Individual author disclosures are available on the abstract.
The study was funded by Japan's Ministry of Health, Labour and Welfare.
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|SOURCE American Heart Association|
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