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Type 2 Diabetics Studied in Low-Dose Aspirin Trial
Date:11/11/2008

Study highlights:

- In a large primary prevention trial on low-dose aspirin in diabetics, Japanese investigators report that daily aspirin did not have a significant benefit in preventing the primary endpoints of all atherosclerotic events, although it did protect against fatal heart attack and stroke.

- Low-dose aspirin was also associated with a reduced risk of fatal and non-fatal atherosclerotic events, but only in a subgroup of diabetics who were over age 65.

NEW ORLEANS, Nov. 11 /PRNewswire-USNewswire/ -- Type 2 diabetics treated with low-dose aspirin did not have a significantly lower incidence of atherosclerotic events than those who received placebo in this primary prevention trial of low-dose aspirin, according to research presented at the American Heart Association's Scientific Sessions 2008. However, sub-group analyses showed a significant reduction with aspirin in both atherosclerotic events in those over 65 years of age, and a reduction in cerebrocardiovascular deaths. Results from The Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes (JPAD) trial were presented as a late-breaking clinical trial. The study was simultaneously published in the Journal of the American Medical Association.

"Our results indicate that aspirin is effective and safe for primary prevention of cardiac and cerebrocardiovascular death in diabetics," said Hisao Ogawa, M.D, Ph.D., lead investigator of the study and a professor of cardiovascular medicine at Kumamoto University, Kumamoto, Japan, and chief of the division of cardiology at the Kumamoto University Hospital. "In addition, it offers a low-cost approach."

The randomized trial included 2,539 type 2 diabetics at 163 Japanese medical centers.

Researchers observed a positive trend for a reduction in all atherosclerotic events in the aspirin group (20 percent relative risk reduction) for the entire population, but it did not reach statistical significance. At
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SOURCE American Heart Association
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