Navigation Links
Type 1 diabetes research at UC San Diego gets $5 million boost

Maike Sander, MD, associate professor of pediatrics and cellular & molecular medicine at the University of California, San Diego School of Medicine has been awarded nearly $5 million by the Beta Cell Biology Consortium (BCBC) to lead an interdisciplinary team in cell therapy research for type 1 diabetes. Sander will lead a team of domestic and international collaborators, with the aim of generating replacement insulin-producing beta cells from patient-derived induced pluripotent stem cells.

The $4,950,000 grant is shared with Karl Willert, PhD, director of the UCSD Human Stem Cell Core Facility, who will apply a screening platform for cellular microenvironments to beta cell differentiation (the process by which cells become progressively more specialized.) Additional participants include labs at the University of Pennsylvania and in Barcelona, Spain, as well as a San Diego-based biotech company.

Sander is a physician-scientist with UCSD's Pediatric Diabetes Research Center (PDRC). Launched the summer of 2008, the PDRC brings together top-ranked physicians and research scientists to investigate the causes and cure of type 1 diabetes.

Type 1 diabetes can occur at any age; however, half of the patients are diagnosed before the age of 20. Though the exact cause is unknown, genetics, viruses, and environmental factors are thought to play a role in causing the autoimmune response that eventually leads to beta cell destruction.

The major focus of Sander's current research is to understand the molecular mechanisms underlying the ability of pluripotent stem cells, or progenitor cells, to produce the different cell types of the pancreas. Specifically, she and her team want to be able to instruct patient-derived pluripotent stem cells to become beta cells.

Since the first pioneering work on islet transplantation, it has become clear that a cell-based approach for the treatment of type 1 diabetes can have significant benefits in terms of insulin independence and a reduced risk of hypoglycemia.

"Right now, scientists can create pancreatic progenitor cells from human embryonic stem cells. However, our goal is to take it a step further and make replacement beta cells from the patient's own tissue," Sander said. "This grant is a perfect example of collaboration and translational medicine for a greater cause. It's not about who discovers the cure first. It's about finding a cure fast."


Contact: Debra Kain
University of California -- San Diego

Related medicine news :

1. OHSU research team joins elite consortium dedicated to curing type 1 diabetes
2. Congressman to speak at meeting on diabetes and obesity
3. Drug holds promise to halt debilitating condition of diabetes
4. Immune System Genes Show Links to Type 1 Diabetes
5. Diabetes Drug Metformin Linked to Lower Lung Cancer Rate in Mice
6. New study singles out factors linked to cognitive deficits in type 2 diabetes
7. Moms who dont breastfeed more likely to develop type 2 diabetes
8. Diabetes impairs but does not halt sex among older adults
9. Link Between Diabetes, Alzheimers Disease Strengthened
10. Heart Risks the Same With 2 Diabetes Drugs: Study
11. Fat distribution plays a role in weight loss success in patients at risk of diabetes
Post Your Comments:
Related Image:
Type 1 diabetes research at UC San Diego gets $5 million boost
(Date:11/27/2015)... , ... November 27, 2015 , ... ... November 27th edition of USA Today in Atlanta, Dallas, New York, Minneapolis, South ... 750,000. The digital component is distributed nationally, through a vast social media strategy ...
(Date:11/27/2015)... ... ... No.1 Herpes-only dating community in the world, revealed that over 50% of its members are ... people under the age of 50 – or 67% of the population - are infected ... HSV-1 infection . , "The data shocks us highly!" said Michelle Li, Co-Founder of ...
(Date:11/27/2015)... ... 27, 2015 , ... Intellitec Solutions announced today that they ... Recognized as Microsoft’s official group for end users of Dynamics SL ERP software, ... industry experts and representatives. Intellitec Solutions’ membership status demonstrates their ongoing commitment to ...
(Date:11/27/2015)... MINNEAPOLIS, Minn. (PRWEB) , ... November 27, 2015 ... ... you start failing. Secura Consultants has prided itself for not only fulfilling the ... best income protection solutions at an affordable price and providing top-tier customer service. ...
(Date:11/27/2015)... ... November 27, 2015 , ... CBD College is ... Health Education Programs (CAAHEP) awarded accreditation to its Diagnostic Medical Sonography program. CBD College ... as only one of twelve colleges and universities in the state of California make ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... Carolina , 26 november 2015 /PRNewswire/ ... (AAIPharma/CML) kondigt de geplande investering aan van ... van de laboratoria en het mondiale hoofdkantoor ... De uitbreiding zal resulteren in extra kantoorruimte ... voldaan aan de groeiende behoeften van de ...
(Date:11/26/2015)... , November 26, 2015 --> ... to use SyMRI to find optimal contrast weighting of MRI ... metastases, and has signed a research agreement with SyntheticMR in ... hospital. Using SyMRI, it is possible to generate multiple contrast ... after the patient has left, thus making it possible to ...
(Date:11/26/2015)... , Nov. 26, 2015 Research and ... of the "2016 Future Horizons and Growth ... Market: Supplier Shares, Country Segment Forecasts, Competitive Intelligence, ... --> --> ... of the Japanese therapeutic drug monitoring market, including ...
Breaking Medicine Technology: